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Gene Review:

uspA - universal stress protein A

Escherichia coli CFT073

Liu, W.T. et al., Sidjabat, H.E. et al.

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Disease relevance of uspA

These were then tested by multiplex PCR for E. coli uspA, bla(CMY) and the class 1 integron-associated dfrA17-aadA5 gene cassette for rapid identification of MDREC CG 1 (positive for all three genes) and CG 2 (positive for uspA and bla(CMY) only) [1].
Role of the universal stress protein UspA of Salmonella in growth arrest, stress and virulence [2].

High impact information on uspA

Inactivation of uspA in S. typhimurium C5, lead to increased susceptibility to stress conditions [2].
An in silico screen of the Salmonella genome sequence revealed that Salmonella typhimurium LT2 possesses a homologue belonging to the universal stress protein A (UspA) family [2].
Furthermore, UspA makes an important contribution to the in vivo virulence of Salmonella in mice thus highlighting the importance of stress resistance regulation in pathogenicity and survival within the host [2].

References

Emergence and spread of two distinct clonal groups of multidrug-resistant Escherichia coli in a veterinary teaching hospital in Australia. Sidjabat, H.E., Townsend, K.M., Lorentzen, M., Gobius, K.S., Fegan, N., Chin, J.J., Bettelheim, K.A., Hanson, N.D., Bensink, J.C., Trott, D.J. J. Med. Microbiol. (2006) [Pubmed]
Role of the universal stress protein UspA of Salmonella in growth arrest, stress and virulence. Liu, W.T., Karavolos, M.H., Bulmer, D.M., Allaoui, A., Hormaeche, R.D., Lee, J.J., Anjam Khan, C.M. Microb. Pathog. (2007) [Pubmed]

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