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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

CIB2  -  calcium and integrin binding family member 2

Homo sapiens

Synonyms: Calcium and integrin-binding family member 2, DFNB48, KIP 2, KIP2, Kinase-interacting protein 2, ...
 
 
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High impact information on CIB2

  • Moreover, similar abnormalities (e.g. delay in late mitotic stages with the accumulation of aberrant ana-telophase figures, and abnormalities in the following interphase) are observed in cultures in which the expression of Kip2/p57 is abrogated by siRNAs [1].
  • In contrast, EGCG accelerates terminal differentiation in normal human epidermal keratinocytes (NHEK) mediated partially by up-regulation of p57/KIP2, a cyclin-dependent kinase inhibitor that confers growth arrest and differentiation [2].
  • This protein (termed KIP2 for kinase interacting protein 2) has sequence homology to KIP (46% identical and 64% similarity) [3].

References

  1. A role of p73 in mitotic exit. Merlo, P., Fulco, M., Costanzo, A., Mangiacasale, R., Strano, S., Blandino, G., Taya, Y., Lavia, P., Levrero, M. J. Biol. Chem. (2005) [Pubmed]
  2. Green tea polyphenol-induced epidermal keratinocyte differentiation is associated with coordinated expression of p57/KIP2 and caspase 14. Hsu, S., Yamamoto, T., Borke, J., Walsh, D.S., Singh, B., Rao, S., Takaaki, K., Nah-Do, N., Lapp, C., Lapp, D., Foster, E., Bollag, W.B., Lewis, J., Wataha, J., Osaki, T., Schuster, G. J. Pharmacol. Exp. Ther. (2005) [Pubmed]
  3. Structure, expression profile and chromosomal location of an isolog of DNA-PKcs interacting protein (KIP) gene. Seki, N., Hattori, A., Hayashi, A., Kozuma, S., Ohira, M., Hori, T., Saito, T. Biochim. Biophys. Acta (1999) [Pubmed]
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