The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Editor

Share

Personal info

View

Links

  • Homologues
  • NCBI Gene
  • NCBI SNP
  • iHOP resource
  • OMIM
  • SNPedia
  • UniProt
  • Ensembl
  • HGNC

Table of contents

About

Terms

 

Gene Review: 

DDX17  -  DEAD (Asp-Glu-Ala-Asp) box helicase 17

Homo sapiens

Synonyms: DEAD box protein 17, DEAD box protein p72, P72, RH70, RNA-dependent helicase p72
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

High impact information on DDX17

  • P72, a novel human member of the DEAD box family of putative RNA-dependent ATPases and ATP-dependent RNA helicases was isolated from a HeLa cDNA library [1].
  • Several reports have noted epidemiological differences in the prevalence or prognostic significance of p53 mutants with arginine (R) or proline (P) at the codon 72 polymorphism (R72/P72) in certain cancer types, but the biological significance of these variants is unclear [2].
  • Polymorphism at position 72 mainly affected peptide/HLA-B7 binding, the proline allele P72 giving a less-reactive peptide (63-73) than the arginine allele R72 [3].
  • P72 and P75 were shown to bind Src homology domains 3 (SH3) and have been implicated in many biological functions of Nef, including downmodulation of cell-surface major histocompatibility complex class I (MHC-I) [4].
  • DDX5 (p68) and its related DDX17 (p72) have also been implicated in organ/tissue differentiation [5].
 

Biological context of DDX17

 

Analytical, diagnostic and therapeutic context of DDX17

  • Peptide sequence analysis by mass spectrometry and Edman degradation revealed that RH70 is the previously reported DDX17 [7].
  • Changes in [3H]glutamate (Glu) binding occurring in the lower medulla of the rat between birth (P0) and adulthood (P72) were investigated on cryostat sections using in vitro receptor autoradiography [8].

References

  1. p72: a human nuclear DEAD box protein highly related to p68. Lamm, G.M., Nicol, S.M., Fuller-Pace, F.V., Lamond, A.I. Nucleic Acids Res. (1996) [Pubmed]
  2. Inactivate the remaining p53 allele or the alternate p73? Preferential selection of the Arg72 polymorphism in cancers with recessive p53 mutants but not transdominant mutants. Tada, M., Furuuchi, K., Kaneda, M., Matsumoto, J., Takahashi, M., Hirai, A., Mitsumoto, Y., Iggo, R.D., Moriuchi, T. Carcinogenesis (2001) [Pubmed]
  3. Mapping and ranking of potential cytotoxic T epitopes in the p53 protein: effect of mutations and polymorphism on peptide binding to purified and refolded HLA molecules. Gnjatic, S., Bressac-de Paillerets, B., Guillet, J.G., Choppin, J. Eur. J. Immunol. (1995) [Pubmed]
  4. The Pro78 residue regulates the capacity of the human immunodeficiency virus type 1 Nef protein to inhibit recycling of major histocompatibility complex class I molecules in an SH3-independent manner. Casartelli, N., Giolo, G., Neri, F., Haller, C., Potestà, M., Rossi, P., Fackler, O.T., Doria, M. J. Gen. Virol. (2006) [Pubmed]
  5. RNA helicases: regulators of differentiation. Abdelhaleem, M. Clin. Biochem. (2005) [Pubmed]
  6. Reduced neuropeptide Y mRNA levels in the frontal cortex of people with schizophrenia and bipolar disorder. Kuromitsu, J., Yokoi, A., Kawai, T., Nagasu, T., Aizawa, T., Haga, S., Ikeda, K. Brain Res. Gene Expr. Patterns (2001) [Pubmed]
  7. RH70, a bidirectional RNA helicase, co-purifies with U1snRNP. Lee, C.G. J. Biol. Chem. (2002) [Pubmed]
  8. Postnatal changes in glutamate binding in the lower medulla of the rat. Rao, H., Jean, A., Kessler, J.P. Neurosci. Lett. (1995) [Pubmed]
Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenesOpen Access LicencePrivacy PolicyTerms of Useapsburg
 
WikiGenes - Universities