Gene Review:
DDX5 - DEAD (Asp-Glu-Ala-Asp) box helicase 5
Homo sapiens
Synonyms:
DEAD box protein 5, G17P1, HELR, HLR1, HUMP68, ...
- Identification of two gene variants associated with risk of advanced fibrosis in patients with chronic hepatitis C. Huang, H., Shiffman, M.L., Cheung, R.C., Layden, T.J., Friedman, S., Abar, O.T., Yee, L., Chokkalingam, A.P., Schrodi, S.J., Chan, J., Catanese, J.J., Leong, D.U., Ross, D., Hu, X., Monto, A., McAllister, L.B., Broder, S., White, T., Sninsky, J.J., Wright, T.L. Gastroenterology (2006)
- Chromosome mapping of the human gene encoding the 68-kDa nuclear antigen (p68) by using the polymerase chain reaction. Iggo, R., Gough, A., Xu, W., Lane, D.P., Spurr, N.K. Proc. Natl. Acad. Sci. U.S.A. (1989)
- Intracellular interaction of EBV/C3d receptor (CR2) with p68, a calcium-binding protein present in normal but not in transformed B lymphocytes. Barel, M., Gauffre, A., Lyamani, F., Fiandino, A., Hermann, J., Frade, R. J. Immunol. (1991)
- Cellular RNA helicase p68 relocalization and interaction with the hepatitis C virus (HCV) NS5B protein and the potential role of p68 in HCV RNA replication. Goh, P.Y., Tan, Y.J., Lim, S.P., Tan, Y.H., Lim, S.G., Fuller-Pace, F., Hong, W. J. Virol. (2004)
- Nuclear protein p68 is an RNA-dependent ATPase. Iggo, R.D., Lane, D.P. EMBO J. (1989)
- Involvement of RNA helicases p68 and p72 in colon cancer. Shin, S., Rossow, K.L., Grande, J.P., Janknecht, R. Cancer Res. (2007)
- P68 RNA Helicase Mediates PDGF-Induced Epithelial Mesenchymal Transition by Displacing Axin from beta-Catenin. Yang, L., Lin, C., Liu, Z.R. Cell (2006)
- Nuclear protein with sequence homology to translation initiation factor eIF-4A. Ford, M.J., Anton, I.A., Lane, D.P. Nature (1988)
- The Drosophila P68 RNA helicase regulates transcriptional deactivation by promoting RNA release from chromatin. Buszczak, M., Spradling, A.C. Genes Dev. (2006)
- The differential processing of homodimers of reverse transcriptases from human immunodeficiency viruses type 1 and 2 is a consequence of the distinct specificities of the viral proteases. Fan, N., Rank, K.B., Leone, J.W., Heinrikson, R.L., Bannow, C.A., Smith, C.W., Evans, D.B., Poppe, S.M., Tarpley, W.G., Rothrock, D.J. J. Biol. Chem. (1995)
- The nuclear DEAD box RNA helicase p68 interacts with the nucleolar protein fibrillarin and colocalizes specifically in nascent nucleoli during telophase. Nicol, S.M., Causevic, M., Prescott, A.R., Fuller-Pace, F.V. Exp. Cell Res. (2000)
- Roles of hnRNP A1, SR proteins, and p68 helicase in c-H-ras alternative splicing regulation. Guil, S., Gattoni, R., Carrascal, M., Abián, J., Stévenin, J., Bach-Elias, M. Mol. Cell. Biol. (2003)
- p68 RNA helicase is an essential human splicing factor that acts at the U1 snRNA-5' splice site duplex. Liu, Z.R. Mol. Cell. Biol. (2002)
- p68 DEAD box RNA helicase expression in keratinocytes. Regulation, nucleolar localization, and functional connection to proliferation and vascular endothelial growth factor gene expression. Kahlina, K., Goren, I., Pfeilschifter, J., Frank, S. J. Biol. Chem. (2004)
- ADAMTS4 (aggrecanase-1) activation on the cell surface involves C-terminal cleavage by glycosylphosphatidyl inositol-anchored membrane type 4-matrix metalloproteinase and binding of the activated proteinase to chondroitin sulfate and heparan sulfate on syndecan-1. Gao, G., Plaas, A., Thompson, V.P., Jin, S., Zuo, F., Sandy, J.D. J. Biol. Chem. (2004)
- Nucleocytoplasmic sorting of macromolecules following mitosis: fate of nuclear constituents after inhibition of pore complex function. Benavente, R., Scheer, U., Chaly, N. Eur. J. Cell Biol. (1989)
- A nuclear juvenile hormone-binding protein from larvae of Manduca sexta: a putative receptor for the metamorphic action of juvenile hormone. Palli, S.R., Touhara, K., Charles, J.P., Bonning, B.C., Atkinson, J.K., Trowell, S.C., Hiruma, K., Goodman, W.G., Kyriakides, T., Prestwich, G.D. Proc. Natl. Acad. Sci. U.S.A. (1994)
- Functional expression and RNA binding analysis of the interferon-induced, double-stranded RNA-activated, 68,000-Mr protein kinase in a cell-free system. Katze, M.G., Wambach, M., Wong, M.L., Garfinkel, M., Meurs, E., Chong, K., Williams, B.R., Hovanessian, A.G., Barber, G.N. Mol. Cell. Biol. (1991)
- Crystallization of p68 on lipid monolayers and as three-dimensional single crystals. Newman, R., Tucker, A., Ferguson, C., Tsernoglou, D., Leonard, K., Crumpton, M.J. J. Mol. Biol. (1989)
- Characterization of Ca2(+)-dependent phospholipid binding, vesicle aggregation and membrane fusion by annexins. Blackwood, R.A., Ernst, J.D. Biochem. J. (1990)
- Identification of the human DEAD-box protein p68 as a substrate of Tlk1. Kodym, R., Henöckl, C., Fürweger, C. Biochem. Biophys. Res. Commun. (2005)
- The DEAD box protein p68: a novel transcriptional coactivator of the p53 tumour suppressor. Bates, G.J., Nicol, S.M., Wilson, B.J., Jacobs, A.M., Bourdon, J.C., Wardrop, J., Gregory, D.J., Lane, D.P., Perkins, N.D., Fuller-Pace, F.V. EMBO J. (2005)
- RNA helicases: regulators of differentiation. Abdelhaleem, M. Clin. Biochem. (2005)
- The highly related DEAD box RNA helicases p68 and p72 exist as heterodimers in cells. Ogilvie, V.C., Wilson, B.J., Nicol, S.M., Morrice, N.A., Saunders, L.R., Barber, G.N., Fuller-Pace, F.V. Nucleic Acids Res. (2003)
- Structure and expression of the human p68 RNA helicase gene. Rössler, O.G., Hloch, P., Schütz, N., Weitzenegger, T., Stahl, H. Nucleic Acids Res. (2000)