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Gene Review:

PSORS4 - psoriasis susceptibility 4

Homo sapiens

Giardina, E. et al., Zenz, R. et al., Capon, F. et al.

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Disease relevance of PSORS4

Fine mapping of the PSORS4 psoriasis susceptibility region on chromosome 1q21 [1].

High impact information on PSORS4

We mapped an additional susceptibility locus on chromosome 1q21 (PSORS4) [1].
This rules out the LOR gene as a candidate for the PSORS4 locus [2].
We mapped one of these loci, PSORS4, on human chromosome 1q21 [2].
Characterization of the loricrin (LOR) gene as a positional candidate for the PSORS4 psoriasis susceptibility locus [2].
Prior to the disease onset, two chemotactic proteins (S100A8 and S100A9) previously mapped to the psoriasis susceptibility region PSORS4, are strongly induced in mutant keratinocytes in vivo and in vitro [3].

References

Fine mapping of the PSORS4 psoriasis susceptibility region on chromosome 1q21. Capon, F., Semprini, S., Chimenti, S., Fabrizi, G., Zambruno, G., Murgia, S., Carcassi, C., Fazio, M., Mingarelli, R., Dallapiccola, B., Novelli, G. J. Invest. Dermatol. (2001) [Pubmed]
Characterization of the loricrin (LOR) gene as a positional candidate for the PSORS4 psoriasis susceptibility locus. Giardina, E., Capon, F., De Rosa, M.C., Mango, R., Zambruno, G., Orecchia, A., Chimenti, S., Giardina, B., Novelli, G. Ann. Hum. Genet. (2004) [Pubmed]
Psoriasis-like skin disease and arthritis caused by inducible epidermal deletion of Jun proteins. Zenz, R., Eferl, R., Kenner, L., Florin, L., Hummerich, L., Mehic, D., Scheuch, H., Angel, P., Tschachler, E., Wagner, E.F. Nature (2005) [Pubmed]

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