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Gene Review

IGF2BP2  -  insulin-like growth factor 2 mRNA binding...

Homo sapiens

Synonyms: Hepatocellular carcinoma autoantigen p62, IGF-II mRNA-binding protein 2, IGF2 mRNA-binding protein 2, IMP-2, IMP2, ...
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Disease relevance of IGF2BP2


High impact information on IGF2BP2

  • The IMP-12 enzyme is quite divergent from other IMP variants: its closest relatives are IMP-8 and IMP-2 (89 and 88% sequence identity, respectively), and IMP-1 is 85% identical to IMP-12 [3].
  • The four sequences included an identical 738-bp open reading frame, predicted to encode a polypeptide of 246 amino acids, with 95.6% homology to IMP-1 and 89.3% homology to IMP-2 [4].
  • p62 is a cancer-associated antigen binding to mRNA encoding insulin-like growth factor II that was isolated by immunoscreening a cDNA expression library with autoantibodies from patients with hepatocellular carcinoma (HCC) [1].
  • These results suggest that there is a significant association between expression and distribution of p62 and the growth arrest of tumor cells, in which p62 is associated with cell apoptosis induced by ATRA [1].
  • Interestingly, we found that p62 was cytoplasmic in location, but it significantly decreased in cytoplasm and appeared in nucleus of cells when the cells were treated with 50 microM all-trans retinoic acid (ATRA) for 5 days [1].

Associations of IGF2BP2 with chemical compounds

  • The effect of different cyclodextrins (CDs), namely, gamma-cyclodextrin (gamma-CD), hydroxypropyl-beta-CD (HP-beta-CD), and alpha-cyclodextrin (alpha-CD), on effective mobility and enantiomeric resolution (R) of venlafaxine (Wy45030) and its impurities (imp1 and imp2) was studied at different pHs, and the best results were obtained at pH 9 [5].

Analytical, diagnostic and therapeutic context of IGF2BP2

  • Of these 431 strains, 357 were found by PCR to carry genes for IMP-1 type MBL (bla(IMP-1)), while only 7 and 67 strains carried the IMP-2 gene (bla(IMP-2)) and the VIM-2 gene (bla(VIM-2)), respectively [6].
  • Log-rank testing showed that IMP-1 overexpression (p=0.0398) and an advanced clinical stage (p=0.0050) were significantly correlated with poor patient survival, whereas neither IMP-2 nor IMP-3 overexpression were associated with poor prognoses [7].


  1. Effect of all-trans-retinoic acid on mRNA binding protein p62 in human gastric cancer cells. Ping, S., Wang, S., Zhang, J., Peng, X. Int. J. Biochem. Cell Biol. (2005) [Pubmed]
  2. Expression of metalloproteinases and metalloproteinase inhibitors by fetal astrocytes and glioma cells. Apodaca, G., Rutka, J.T., Bouhana, K., Berens, M.E., Giblin, J.R., Rosenblum, M.L., McKerrow, J.H., Banda, M.J. Cancer Res. (1990) [Pubmed]
  3. IMP-12, a new plasmid-encoded metallo-beta-lactamase from a Pseudomonas putida clinical isolate. Docquier, J.D., Riccio, M.L., Mugnaioli, C., Luzzaro, F., Endimiani, A., Toniolo, A., Amicosante, G., Rossolini, G.M. Antimicrob. Agents Chemother. (2003) [Pubmed]
  4. IMP-4, a novel metallo-beta-lactamase from nosocomial Acinetobacter spp. collected in Hong Kong between 1994 and 1998. Chu, Y.W., Afzal-Shah, M., Houang, E.T., Palepou, M.I., Lyon, D.J., Woodford, N., Livermore, D.M. Antimicrob. Agents Chemother. (2001) [Pubmed]
  5. Analysis of venlafaxine by capillary zone electrophoresis. Fanali, S., Cotichini, V., Porrà, R. Journal of capillary electrophoresis. (1997) [Pubmed]
  6. PCR typing of genetic determinants for metallo-beta-lactamases and integrases carried by gram-negative bacteria isolated in Japan, with focus on the class 3 integron. Shibata, N., Doi, Y., Yamane, K., Yagi, T., Kurokawa, H., Shibayama, K., Kato, H., Kai, K., Arakawa, Y. J. Clin. Microbiol. (2003) [Pubmed]
  7. Increased expression of IGF II mRNA-binding protein 1 mRNA is associated with an advanced clinical stage and poor prognosis in patients with ovarian cancer. Gu, L., Shigemasa, K., Ohama, K. Int. J. Oncol. (2004) [Pubmed]
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