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Gene Review

PTTG2  -  pituitary tumor-transforming 2

Homo sapiens

Synonyms: Pituitary tumor-transforming gene 2 protein, Securin-2
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Disease relevance of PTTG2


High impact information on PTTG2


Biological context of PTTG2

  • While mapping the chromosomal location of hPTTG to 5q33, we discovered a second gene, hPTTG2, which is intronless and maps to chromosome 4p12 [3].


  1. Adenovirus-mediated transfer of siRNA against PTTG1 inhibits liver cancer cell growth in vitro and in vivo. Cho-Rok, J., Yoo, J., Jang, Y.J., Kim, S., Chu, I.S., Yeom, Y.I., Choi, J.Y., Im, D.S. Hepatology (2006) [Pubmed]
  2. Identification of the human pituitary tumor transforming gene (hPTTG) family: molecular structure, expression, and chromosomal localization. Chen, L., Puri, R., Lefkowitz, E.J., Kakar, S.S. Gene (2000) [Pubmed]
  3. An intronless homolog of human proto-oncogene hPTTG is expressed in pituitary tumors: evidence for hPTTG family. Prezant, T.R., Kadioglu, P., Melmed, S. J. Clin. Endocrinol. Metab. (1999) [Pubmed]
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