Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

PTTG2 - pituitary tumor-transforming 2

Homo sapiens

Synonyms: Pituitary tumor-transforming gene 2 protein, Securin-2

Chen, L. et al., Cho-Rok, J. et al., Prezant, T.R. et al.

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Disease relevance of PTTG2

We report that PTTG1, but not PTTG2 and 3, was highly and frequently expressed in liver cancer tissues from patients and highly in SH-J1, SK-Hep1, and Huh-7 hepatoma cell lines [1].

High impact information on PTTG2

Northern blot and reverse transcriptase/polymerase chain reaction (RT/PCR) analyses of the mRNA from various human tissues revealed differential expression of the hPTTG2 and hPTTG3 genes in normal and tumor tissues, suggesting that these genes may be associated with tumorigenesis [2].

Biological context of PTTG2

While mapping the chromosomal location of hPTTG to 5q33, we discovered a second gene, hPTTG2, which is intronless and maps to chromosome 4p12 [3].

References

Adenovirus-mediated transfer of siRNA against PTTG1 inhibits liver cancer cell growth in vitro and in vivo. Cho-Rok, J., Yoo, J., Jang, Y.J., Kim, S., Chu, I.S., Yeom, Y.I., Choi, J.Y., Im, D.S. Hepatology (2006) [Pubmed]
Identification of the human pituitary tumor transforming gene (hPTTG) family: molecular structure, expression, and chromosomal localization. Chen, L., Puri, R., Lefkowitz, E.J., Kakar, S.S. Gene (2000) [Pubmed]
An intronless homolog of human proto-oncogene hPTTG is expressed in pituitary tumors: evidence for hPTTG family. Prezant, T.R., Kadioglu, P., Melmed, S. J. Clin. Endocrinol. Metab. (1999) [Pubmed]

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