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Gene Review:

TOB2 - transducer of ERBB2, 2

Homo sapiens

Synonyms: KIAA1663, Protein Tob2, Protein Tob4, TOB4, TOBL, ...

Ikematsu, N. et al., Ajima, R. et al., Sasajima, H. et al.

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High impact information on TOB2

However, further in situ hybridization analysis showed a characteristic expression of the tob2 mRNA in oocytes, suggesting a unique role of Tob2 in oogenesis [1].
Finally, the tob2 gene was mapped to human chromosome 22q13.1-q13.31 [1].
The tob2 gene contains an open reading frame of 345 amino acids with an 89% identity to its human counterparts [2].
In addition, in situ hybridization shows that tob2 is ubiquitously expressed in embryo, the level of expression being especially high in skeletal muscle [2].
Thus, it can be concluded that the C-terminal regions are necessary and sufficient to control the stabilities of BTG1, BTG2, Tob, and Tob2 proteins [3].

Analytical, diagnostic and therapeutic context of TOB2

The tob2 mRNA was 4.1 kb long and was ubiquitously expressed in human adult tissues, as was revealed by Northern blot hybridization [1].

References

Tob2, a novel anti-proliferative Tob/BTG1 family member, associates with a component of the CCR4 transcriptional regulatory complex capable of binding cyclin-dependent kinases. Ikematsu, N., Yoshida, Y., Kawamura-Tsuzuku, J., Ohsugi, M., Onda, M., Hirai, M., Fujimoto, J., Yamamoto, T. Oncogene (1999) [Pubmed]
Cloning and characterization of the mouse tob2 gene. Ajima, R., Ikematsu, N., Ohsugi, M., Yoshida, Y., Yamamoto, T. Gene (2000) [Pubmed]
Antiproliferative proteins of the BTG/Tob family are degraded by the ubiquitin-proteasome system. Sasajima, H., Nakagawa, K., Yokosawa, H. Eur. J. Biochem. (2002) [Pubmed]

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