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Gene Review

BTG1  -  B-cell translocation gene 1, anti...

Homo sapiens

Synonyms: B-cell translocation gene 1 protein, Protein BTG1
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Disease relevance of BTG1


High impact information on BTG1


Biological context of BTG1


Anatomical context of BTG1

  • In conclusion, ANA is a fourth member of the Tob/BTG1 family that might play roles in neurogenesis in the central nervous system [9].
  • Human carbon catabolite repressor protein (CCR4)-associative factor 1: cloning, expression and characterization of its interaction with the B-cell translocation protein BTG1 [7].
  • Cell synchrony experiments with primary cultures of rat aortic smooth-muscle cells (RSMCs) demonstrated that message and protein levels of rat CAF-1 (rCAF-1) were up-regulated under conditions of cell contact, as previously reported for BTG1 [Wilcox, Scott, Subramanian, Ross, Adams-Burton, Stoltenborg and Corjay (1995) Circulation 92, I34-I35] [7].
  • We have previously shown that BTG1 stimulates myoblast differentiation [10].
  • In this study, we report that BTG1 is essentially expressed at cell confluence and in differentiated myotubes [11].

Associations of BTG1 with chemical compounds


Other interactions of BTG1


Analytical, diagnostic and therapeutic context of BTG1

  • Western blot and immunohistochemical analysis showed that rCAF-1 localizes to the nucleus of contact-inhibited RSMCs, where it was physically associated with BTG1, as determined by co-immunoprecipitation with anti-hCAF-1 antisera [7].
  • Sequence and Northern blot analyses indicate that BTG1 and PC3 are not cognate genes [1].
  • In situ hybridization and immunodetection studies demonstrated that BTG1 localized to specific macrophage-rich regions of lesions in both Watanabe heritable hyperlipidemic rabbits and humans [15].


  1. BTG1, a member of a new family of antiproliferative genes. Rouault, J.P., Rimokh, R., Tessa, C., Paranhos, G., Ffrench, M., Duret, L., Garoccio, M., Germain, D., Samarut, J., Magaud, J.P. EMBO J. (1992) [Pubmed]
  2. B cell translocation gene 1 contributes to antisense Bcl-2-mediated apoptosis in breast cancer cells. Nahta, R., Yuan, L.X., Fiterman, D.J., Zhang, L., Symmans, W.F., Ueno, N.T., Esteva, F.J. Mol. Cancer Ther. (2006) [Pubmed]
  3. Change of the cell cycle after flutamide treatment in prostate cancer cells and its molecular mechanism. Wang, Y., Shao, C., Shi, C.H., Zhang, L., Yue, H.H., Wang, P.F., Yang, B., Zhang, Y.T., Liu, F., Qin, W.J., Wang, H., Shao, G.X. Asian J. Androl. (2005) [Pubmed]
  4. Identification of B-cell translocation gene 1 as a biomarker for monitoring the remission of acute myeloid leukemia. Cho, J.W., Kim, J.J., Park, S.G., Lee, d.o. .H., Lee, S.C., Kim, H.J., Park, B.C., Cho, S. Proteomics (2004) [Pubmed]
  5. FoxO3a regulates erythroid differentiation and induces BTG1, an activator of protein arginine methyl transferase 1. Bakker, W.J., Blázquez-Domingo, M., Kolbus, A., Besooyen, J., Steinlein, P., Beug, H., Coffer, P.J., Löwenberg, B., von Lindern, M., van Dijk, T.B. J. Cell Biol. (2004) [Pubmed]
  6. The leukemia-associated protein Btg1 and the p53-regulated protein Btg2 interact with the homeoprotein Hoxb9 and enhance its transcriptional activation. Prévôt, D., Voeltzel, T., Birot, A.M., Morel, A.P., Rostan, M.C., Magaud, J.P., Corbo, L. J. Biol. Chem. (2000) [Pubmed]
  7. Human carbon catabolite repressor protein (CCR4)-associative factor 1: cloning, expression and characterization of its interaction with the B-cell translocation protein BTG1. Bogdan, J.A., Adams-Burton, C., Pedicord, D.L., Sukovich, D.A., Benfield, P.A., Corjay, M.H., Stoltenborg, J.K., Dicker, I.B. Biochem. J. (1998) [Pubmed]
  8. BTG gene expression in the p53-dependent and -independent cellular response to DNA damage. Cortes, U., Moyret-Lalle, C., Falette, N., Duriez, C., Ghissassi, F.E., Barnas, C., Morel, A.P., Hainaut, P., Magaud, J.P., Puisieux, A. Mol. Carcinog. (2000) [Pubmed]
  9. ANA, a novel member of Tob/BTG1 family, is expressed in the ventricular zone of the developing central nervous system. Yoshida, Y., Matsuda, S., Ikematsu, N., Kawamura-Tsuzuku, J., Inazawa, J., Umemori, H., Yamamoto, T. Oncogene (1998) [Pubmed]
  10. Identification of functional domains involved in BTG1 cell localization. Rodier, A., Rochard, P., Berthet, C., Rouault, J.P., Casas, F., Daury, L., Busson, M., Magaud, J.P., Wrutniak-Cabello, C., Cabello, G. Oncogene (2001) [Pubmed]
  11. BTG1: a triiodothyronine target involved in the myogenic influence of the hormone. Rodier, A., Marchal-Victorion, S., Rochard, P., Casas, F., Cassar-Malek, I., Rouault, J.P., Magaud, J.P., Mason, D.Y., Wrutniak, C., Cabello, G. Exp. Cell Res. (1999) [Pubmed]
  12. Coactivation of nuclear receptors and myogenic factors induces the major BTG1 influence on muscle differentiation. Busson, M., Carazo, A., Seyer, P., Grandemange, S., Casas, F., Pessemesse, L., Rouault, J.P., Wrutniak-Cabello, C., Cabello, G. Oncogene (2005) [Pubmed]
  13. Schistosoma hematobium soluble egg antigens induce proliferation of urothelial and endothelial cells. El-Awady, M.K., Gad, Y.Z., Wen, Y., Eassawi, M., Effat, L., Amr, K.S., Ismail, S., Christ, G.J. World journal of urology. (2001) [Pubmed]
  14. Regulation of protein tyrosine phosphatase 4a1, B-cell translocation gene 2, nuclear receptor subfamily 4a1 and diacylglycerol O-acyltransferase 1 by follicle stimulating hormone in the rat ovary. Schmidt, J., de Avila, J., McLean, D. Reprod. Fertil. Dev. (2006) [Pubmed]
  15. Antiproliferative gene BTG1 is highly expressed in apoptotic cells in macrophage-rich areas of advanced lesions in Watanabe heritable hyperlipidemic rabbit and human. Corjay, M.H., Kearney, M.A., Munzer, D.A., Diamond, S.M., Stoltenborg, J.K. Lab. Invest. (1998) [Pubmed]
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