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Gene Review:

Aldh1l1 - aldehyde dehydrogenase 1 family, member L1

Mus musculus

Synonyms: 10-FTHFDH, 1810048F20Rik, Aldehyde dehydrogenase family 1 member L1, Cytosolic 10-formyltetrahydrofolate dehydrogenase, FDH, ...

Pumford, N.R. et al., Jaffe, J.J. et al., Wong, Y.L. et al.

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High impact information on Aldh1l1

Covalent binding of acetaminophen to N-10-formyltetrahydrofolate dehydrogenase in mice [1].
N-Terminal and internal amino acid sequences of peptides from the purified 100-kDa acetaminophen-protein adduct were found to be homologous with the deduced amino amino acid sequence from the cDNA of N-10-formyltetrahydrofolate dehydrogenase [1].
The excreted CO2 that was derived from CH3FH4 was due to the presence within the filariae of 10-formyltetrahydrofolate dehydrogenase (EC 1.5.1.6) which catalyzes the deformylation of 10-formyl-tetrahydrofolate [2].
Concentrations of 10-formyltetrahydrofolate dehydrogenase were diminished in hepatic mitochondria of hyperoxic mice [3].

Analytical, diagnostic and therapeutic context of Aldh1l1

Antiserum specific for N-10-formyltetrahydrofolate dehydrogenase and acetaminophen react in a Western blot with the purified 100-kDa acetaminophen-protein adduct [1].

References

Covalent binding of acetaminophen to N-10-formyltetrahydrofolate dehydrogenase in mice. Pumford, N.R., Halmes, N.C., Martin, B.M., Cook, R.J., Wagner, C., Hinson, J.A. J. Pharmacol. Exp. Ther. (1997) [Pubmed]
Involvement of tetrahydrofolate cofactors in de novo purine ribonucleotide synthesis by adult Brugia pahangi and Dirofilaria immitis. Jaffe, J.J., Chrin, L.R. Mol. Biochem. Parasitol. (1981) [Pubmed]
Mitochondrial thiol status in the liver is altered by exposure to hyperoxia. Wong, Y.L., Smith, C.V., McMicken, H.W., Rogers, L.K., Welty, S.E. Toxicol. Lett. (2001) [Pubmed]

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