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Gene Review

ALDH1L1  -  aldehyde dehydrogenase 1 family, member L1

Homo sapiens

Synonyms: 10-FTHFDH, 10-fTHF, Aldehyde dehydrogenase family 1 member L1, Cytosolic 10-formyltetrahydrofolate dehydrogenase, FDH, ...
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Disease relevance of ALDH1L1


High impact information on ALDH1L1


Biological context of ALDH1L1


Anatomical context of ALDH1L1


Associations of ALDH1L1 with chemical compounds


Other interactions of ALDH1L1


Analytical, diagnostic and therapeutic context of ALDH1L1

  • The distribution of 10-FTHFDH transcript in various human tissues was studied by Northern blot analysis using poly(A+) RNAs from different tissues [5].


  1. Identification of a heritable deficiency of the folate-dependent enzyme 10-formyltetrahydrofolate dehydrogenase in mice. Champion, K.M., Cook, R.J., Tollaksen, S.L., Giometti, C.S. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  2. Regulation of folate-mediated one-carbon metabolism by 10-formyltetrahydrofolate dehydrogenase. Anguera, M.C., Field, M.S., Perry, C., Ghandour, H., Chiang, E.P., Selhub, J., Shane, B., Stover, P.J. J. Biol. Chem. (2006) [Pubmed]
  3. Disruption of a calmodulin central helix-like region of 10-formyltetrahydrofolate dehydrogenase impairs its dehydrogenase activity by uncoupling the functional domains. Reuland, S.N., Vlasov, A.P., Krupenko, S.A. J. Biol. Chem. (2003) [Pubmed]
  4. Ectopic expression of 10-formyltetrahydrofolate dehydrogenase in A549 cells induces G1 cell cycle arrest and apoptosis. Oleinik, N.V., Krupenko, S.A. Mol. Cancer Res. (2003) [Pubmed]
  5. Isolation and characterization of cDNA clone for human liver 10-formyltetrahydrofolate dehydrogenase. Hong, M., Lee, Y., Kim, J.W., Lim, J.S., Chang, S.Y., Lee, K.S., Paik, S.G., Choe, I.S. Biochem. Mol. Biol. Int. (1999) [Pubmed]
  6. A noncatalytic tetrahydrofolate tight binding site is on the small domain of 10-formyltetrahydrofolate dehydrogenase. Fu, T.F., Maras, B., Barra, D., Schirch, V. Arch. Biochem. Biophys. (1999) [Pubmed]
  7. Modular organization of FDH: Exploring the basis of hydrolase catalysis. Reuland, S.N., Vlasov, A.P., Krupenko, S.A. Protein Sci. (2006) [Pubmed]
  8. Studies on the mechanism of methanol poisoning: purification and comparison of rat and human liver 10-formyltetrahydrofolate dehydrogenase. Johlin, F.C., Swain, E., Smith, C., Tephly, T.R. Mol. Pharmacol. (1989) [Pubmed]
  9. On the role of conserved histidine 106 in 10-formyltetrahydrofolate dehydrogenase catalysis: connection between hydrolase and dehydrogenase mechanisms. Krupenko, S.A., Vlasov, A.P., Wagner, C. J. Biol. Chem. (2001) [Pubmed]
  10. Recombinant 10-formyltetrahydrofolate dehydrogenase catalyses both dehydrogenase and hydrolase reactions utilizing the synthetic substrate 10-formyl-5,8-dideazafolate. Krupenko, S.A., Wagner, C., Cook, R.J. Biochem. J. (1995) [Pubmed]
  11. Enzymatic activities of rat liver cytosol 10-formyltetrahydrofolate dehydrogenase. Cook, R.J., Wagner, C. Arch. Biochem. Biophys. (1995) [Pubmed]
  12. Cancer cells activate p53 in response to 10-formyltetrahydrofolate dehydrogenase expression. Oleinik, N.V., Krupenko, N.I., Priest, D.G., Krupenko, S.A. Biochem. J. (2005) [Pubmed]
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