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Gene Review

Baiap2  -  brain-specific angiogenesis inhibitor 1...

Mus musculus

Synonyms: BAI-associated protein 2, BAI1-associated protein 2, Brain-specific angiogenesis inhibitor 1-associated protein 2, IRSp53, Insulin receptor substrate p53, ...
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High impact information on Baiap2

  • Novel isoform of insulin receptor substrate p53/p58 is generated by alternative splicing in the CRIB/SH3-binding region [1].
  • Insulin receptor substrate p53/p58 (IRSp53) is involved in cytoskeletal dynamics and is a candidate disease sensor in polyglutamine expansion neurodegeneration [1].
  • Similarly, ST638, a Src inhibitor, inhibited Golgi polarization and migration but not MTOC polarization, whereas expression of the actin regulator IRSp53 only inhibited cell migration [2].
  • When compared to the real-time PCR results, the SQuISH trade mark method showed almost identical relative levels of IRSp53 to Calsenilin mRNA in all three brain regions analyzed, while the riboprobe-based procedure showed a completely opposite trend [3].
  • Insulin receptor tyrosine kinase substrate of 53-kDa protein (IRSp53) is now known to be a key factor in cytoskeleton reorganization [4].


  1. Novel isoform of insulin receptor substrate p53/p58 is generated by alternative splicing in the CRIB/SH3-binding region. Alvarez, C.E., Sutcliffe, J.G., Thomas, E.A. J. Biol. Chem. (2002) [Pubmed]
  2. Microtubule involvement in NIH 3T3 Golgi and MTOC polarity establishment. Magdalena, J., Millard, T.H., Machesky, L.M. J. Cell. Sci. (2003) [Pubmed]
  3. Standardized quantitative in situ hybridization using radioactive oligonucleotide probes for detecting relative levels of mRNA transcripts verified by real-time PCR. Broide, R.S., Trembleau, A., Ellison, J.A., Cooper, J., Lo, D., Young, W.G., Morrison, J.H., Bloom, F.E. Brain Res. (2004) [Pubmed]
  4. Genomic structure and alternative splicing of the insulin receptor tyrosine kinase substrate of 53-kDa protein. Miyahara, A., Okamura-Oho, Y., Miyashita, T., Hoshika, A., Yamada, M. J. Hum. Genet. (2003) [Pubmed]
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