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Gene Review

Baiap2  -  BAI1-associated protein 2

Rattus norvegicus

Synonyms: BAI-associated protein 2, Brain-specific angiogenesis inhibitor 1-associated protein 2, IRSp53, Insulin receptor substrate p53, Insulin receptor substrate protein of 53 kDa, ...
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Disease relevance of Baiap2


High impact information on Baiap2


Biological context of Baiap2

  • Isoforms of human IRSp53 have been reported, each with a unique amino acid sequence at the C-terminal end [4].

Anatomical context of Baiap2


Associations of Baiap2 with chemical compounds

  • Pharmacological profiles showed that a PKC inhibitor, but not other kinase inhibitors, specifically suppressed the synaptic translocation of IRSp53 in response to NMDA, and the selective activation of PKC with phorbol ester markedly induced the synaptic translocation [6].


  1. Regulation of dendritic spine morphogenesis by insulin receptor substrate 53, a downstream effector of Rac1 and Cdc42 small GTPases. Choi, J., Ko, J., Racz, B., Burette, A., Lee, J.R., Kim, S., Na, M., Lee, H.W., Kim, K., Weinberg, R.J., Kim, E. J. Neurosci. (2005) [Pubmed]
  2. Tiam1-IRSp53 complex formation directs specificity of rac-mediated actin cytoskeleton regulation. Connolly, B.A., Rice, J., Feig, L.A., Buchsbaum, R.J. Mol. Cell. Biol. (2005) [Pubmed]
  3. ProSAP/Shank postsynaptic density proteins interact with insulin receptor tyrosine kinase substrate IRSp53. Bockmann, J., Kreutz, M.R., Gundelfinger, E.D., Böckers, T.M. J. Neurochem. (2002) [Pubmed]
  4. Distinctive tissue distribution and phosphorylation of IRSp53 isoforms. Okamura-Oho, Y., Miyashita, T., Yamada, M. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  5. Insulin receptor substrate protein p53 localization in rats suggests mechanism for specific polyglutamine neurodegeneration. Thomas, E.A., Foye, P.E., Alvarez, C.E., Usui, H., Sutcliffe, J.G. Neurosci. Lett. (2001) [Pubmed]
  6. NMDA receptor-dependent synaptic translocation of insulin receptor substrate p53 via protein kinase C signaling. Hori, K., Yasuda, H., Konno, D., Maruoka, H., Tsumoto, T., Sobue, K. J. Neurosci. (2005) [Pubmed]
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