Gene Review:
Dppa5-ps7 - developmental pluripotency associated 5,...
Mus musculus
Synonyms:
Esg1-ps7, esg-1
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Disease relevance of Dppa5-ps7
- Antibodies directed against a glutathione S-transferase-esg-1 fusion product detect a protein of M(r) approximately 14,000 in F9 embryonal carcinoma cells, but not in differentiated cells [1].
High impact information on Dppa5-ps7
- One of these genes, embryonal stem cell gene 1 (esg-1), was analyzed in detail. esg-1 mRNA is found at high levels in both IMT-11 and F9 embryonal carcinoma cells and disappears during the differentiation of the stem cells [1].
- Apart from the esg-1 gene, which contains two introns, there are at least seven esg-1-related pseudogenes in the mouse genome that differ from the esg-1 gene by the presence of multiple point mutations, by the lack of intervening sequences, and/or by the presence of a polyadenylated stretch at the 3' end [1].
- The esg-1 gene is under stringent transcriptional control in differentiating and differentiated cells, as shown by both nuclear run-on assays and the transient F9 stem cell-specific expression of constructs consisting of esg-1 upstream sequences fused to a luciferase reporter gene [1].
Anatomical context of Dppa5-ps7
- These results strongly suggest that esg-1 is expressed specifically or at least predominantly in embryonal stem cells [1].
References
- Cloning of embryonal stem cell-specific genes: characterization of the transcriptionally controlled gene esg-1. Bierbaum, P., MacLean-Hunter, S., Ehlert, F., Möröy, T., Müller, R. Cell Growth Differ. (1994) [Pubmed]
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