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Gene Review:

HCP5 - HLA complex P5 (non-protein coding)

Homo sapiens

Synonyms: 6S2650E, D6S2650E, HLA class I histocompatibility antigen protein P5, HLA complex protein P5, P5-1, ...

Kulski, J.K. et al., Avoustin, P. et al., Vernet, C. et al.

Kulski, Dawkins,

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Disease relevance of HCP5

Therefore, the P5-1 genomic sequence appears to be an example of an HERV within the MHC that expresses an antisense transcript with a possible role in immunity to retrovirus infection [1].

High impact information on HCP5

Structural analysis of open reading frames (ORFs) confirmed that the P5-1 cDNA is characterized by many stop codons and short putative coding regions resembling the patterns found in the HERV-L nucleotide sequence rather than those found in an mRNA sequence such as expressed by HLA class I genes [1].
Although the function of P5 genes is not known, one of the family members, P5-1, was found previously to be specifically transcribed in lymphoid cells and tissue [1].
A 159 base pair (bp) ORF at the 5' end of the 2535 bp P5-1 mRNA may code for a peptide of 52 amino acids with a domain identical in sequence to the signal peptide of HLA molecules [1].
The corresponding gene P5-1 is composed of the 5' sequence of an MHC class I gene including the promoter region, the first exon, and the half of the first intron fused to an unrelated intron, followed by a large exon [2].
Although the P5-1 sequence showed no similarity to sequences in different databanks, its transcription, which is restricted to lymphoid tissues, argues for an immunological function of its product [3].

References

The P5 multicopy gene family in the MHC is related in sequence to human endogenous retroviruses HERV-L and HERV-16. Kulski, J.K., Dawkins, R.L. Immunogenetics (1999) [Pubmed]
Non-homologous recombination within the major histocompatibility complex creates a transcribed hybrid sequence. Avoustin, P., Ribouchon, M.T., Vernet, C., N'Guyen, B., Crouau-Roy, B., Pontarotti, P. Mamm. Genome (1994) [Pubmed]
A novel coding sequence belonging to a new multicopy gene family mapping within the human MHC class I region. Vernet, C., Ribouchon, M.T., Chimini, G., Jouanolle, A.M., Sidibé, I., Pontarotti, P. Immunogenetics (1993) [Pubmed]

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