The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Gene Review

HCP5  -  HLA complex P5 (non-protein coding)

Homo sapiens

Synonyms: 6S2650E, D6S2650E, HLA class I histocompatibility antigen protein P5, HLA complex protein P5, P5-1, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of HCP5

  • Therefore, the P5-1 genomic sequence appears to be an example of an HERV within the MHC that expresses an antisense transcript with a possible role in immunity to retrovirus infection [1].
 

High impact information on HCP5

  • Structural analysis of open reading frames (ORFs) confirmed that the P5-1 cDNA is characterized by many stop codons and short putative coding regions resembling the patterns found in the HERV-L nucleotide sequence rather than those found in an mRNA sequence such as expressed by HLA class I genes [1].
  • Although the function of P5 genes is not known, one of the family members, P5-1, was found previously to be specifically transcribed in lymphoid cells and tissue [1].
  • A 159 base pair (bp) ORF at the 5' end of the 2535 bp P5-1 mRNA may code for a peptide of 52 amino acids with a domain identical in sequence to the signal peptide of HLA molecules [1].
  • The corresponding gene P5-1 is composed of the 5' sequence of an MHC class I gene including the promoter region, the first exon, and the half of the first intron fused to an unrelated intron, followed by a large exon [2].
  • Although the P5-1 sequence showed no similarity to sequences in different databanks, its transcription, which is restricted to lymphoid tissues, argues for an immunological function of its product [3].

References

  1. The P5 multicopy gene family in the MHC is related in sequence to human endogenous retroviruses HERV-L and HERV-16. Kulski, J.K., Dawkins, R.L. Immunogenetics (1999) [Pubmed]
  2. Non-homologous recombination within the major histocompatibility complex creates a transcribed hybrid sequence. Avoustin, P., Ribouchon, M.T., Vernet, C., N'Guyen, B., Crouau-Roy, B., Pontarotti, P. Mamm. Genome (1994) [Pubmed]
  3. A novel coding sequence belonging to a new multicopy gene family mapping within the human MHC class I region. Vernet, C., Ribouchon, M.T., Chimini, G., Jouanolle, A.M., Sidibé, I., Pontarotti, P. Immunogenetics (1993) [Pubmed]
 
WikiGenes - Universities