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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

RAB10  -  RAB10, member RAS oncogene family

Homo sapiens

Synonyms: Ras-related protein Rab-10
 
 
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High impact information on RAB10

  • Double-labeling experiments with anti-rab10 antisera and wheat germ agglutinin, a trans-Golgi and trans-Golgi network (TGN) marker, demonstrate that rab10p is not localized to the trans-Golgi/TGN [1].
  • Rab10p is not exclusively localized to the endoplasmic reticulum, as identified by anti-calsequestrin immunofluorescence [1].
  • In mammalian cell lines, Rab10 has been localized to the trans-Golgi/trans-Golgi network (Y.-T. Chen et al., 1993, Proc. Natl. Acad. Sci. USA 90, 6508-6512) [1].
  • Depletion of Rab10 by RNA interference has only mild effects on biosynthetic transport and epithelial polarization, but simultaneous inhibition of Rab10 and Rab8a more strongly impairs basolateral sorting [2].
  • In contrast, neither wild-type nor constitutively active GFP-tagged Rab10 restored GLUT4 translocation [3].
 

Analytical, diagnostic and therapeutic context of RAB10

  • Immunoblots and immunofluorescent stainings show that rab10 protein (rab10p) is expressed during all stages of sea urchin early development and in all embryonic cell types [1].

References

  1. Analysis of rab10 localization in sea urchin embryonic cells by three-dimensional reconstruction. Leaf, D.S., Blum, L.D. Exp. Cell Res. (1998) [Pubmed]
  2. Rab10 is Involved in Basolateral Transport in Polarized Madin-Darby Canine Kidney Cells. Schuck, S., Gerl, M.J., Ang, A., Manninen, A., Keller, P., Mellman, I., Simons, K. Traffic (2007) [Pubmed]
  3. Rabs 8A and 14 are targets of the insulin-regulated Rab-GAP AS160 regulating GLUT4 traffic in muscle cells. Ishikura, S., Bilan, P.J., Klip, A. Biochem. Biophys. Res. Commun. (2007) [Pubmed]
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