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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Staining and Labeling

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Disease relevance of Staining and Labeling

  • A comparison of E-CD stainings between primary tumors and their metastatic lesions showed similar results in both synchronous and relapse metastases after therapy [1].
  • To test this hypothesis we compared morphological patterns and immunohistochemical beta-catenin stainings in colonic adenomas and adenocarcinomas with the gastrulation steps [2].
  • Immunoperoxidase stainings for C3 and C9 were performed on liver sections; they showed endothelial deposits of C3 and C9 in the control group subjected to ischemia [3].
  • In histochemical stainings it was found that in carcinomas and in the two specimens classified as group III (containing the most extensive metaplastic changes at disposal), the intracellular mucin was mainly neutral or nonsulfated acidic [4].
  • The MMP-2 immunoreactive protein was evaluated from primary adenocarcinoma of the breast in 453 cases by using a specific monoclonal antibody in immunohistochemical stainings [5].

High impact information on Staining and Labeling


Chemical compound and disease context of Staining and Labeling

  • Immunohistochemical stainings of gp 52 in the formol-fixed sections were almost the same as those of the whole MTV virion, and the results on various cases were as follows: In the mice with endogenous GR-MTV, positivity was first observed at the age of 14 days, while the first expression of exogenous GR-MTV was delayed to the age of 140 days [10].

Biological context of Staining and Labeling


Anatomical context of Staining and Labeling


Associations of Staining and Labeling with chemical compounds

  • Histological examination was performed using aldehyde fuchsin, Grimelius', and Hellerström-Hellman's stainings, and immunoperoxidase labeling of insulin and gastrin [20].
  • The heparan sulfate proteoglycan was found to codistribute with fibronectin, and fibronectin and laminin gave coincidental stainings [21].
  • Positive myeloperoxidase and/or sudan black-B stainings and CD13 positivity in these cases were consistent with the presence of a myeloid involvement [22].
  • Immunohistochemical stainings using specific antibodies that recognize epitopes of each adduct were performed from liver biopsy specimens obtained at 1, 5, and 12 months from micropigs fed either control diet (n = 5) or ethanol-containing diets (n = 5) [23].
  • The histopathological examination with anti-human Hb antibody, hematoxylin/eosin, and oil red O stainings showed that HbV was metabolized within 7 days [24].

Gene context of Staining and Labeling

  • Double immunofluorescence stainings demonstrated coexpression of the CD2 antigen and myeloid markers and allowed the recognition of multiple AML subpopulations [25].
  • Immunofluorescence stainings of ILK-hk cells indicated disturbed ILK and paxillin membrane localization with concomitant decrease in focal adhesions [26].
  • Immunohistochemical stainings using anti-EGF and anti-TGF alpha antibodies showed a specific staining in ampullary oviduct epithelium at late follicular and luteal stages, but the stainings were very weak at early follicular stage [27].
  • As expected, p21 and p53 stainings were inversely related to each other (P < 0.001) [28].
  • Immunohistochemical stainings using anti-ICAM-1 antibodies demonstrated a marked increase of ICAM-1 in the ischemic cortex over the nonischemic cortex or the sham-operated samples [29].

Analytical, diagnostic and therapeutic context of Staining and Labeling


  1. Immunohistochemical detection of E-cadherin in differentiated thyroid carcinomas correlates with clinical outcome. von Wasielewski, R., Rhein, A., Werner, M., Scheumann, G.F., Dralle, H., Pötter, E., Brabant, G., Georgii, A. Cancer Res. (1997) [Pubmed]
  2. Patterning and nuclear beta-catenin expression in the colonic adenoma-carcinoma sequence. Analogies with embryonic gastrulation. Kirchner, T., Brabletz, T. Am. J. Pathol. (2000) [Pubmed]
  3. Regulation of the complement cascade by soluble complement receptor type 1. Protective effect in experimental liver ischemia and reperfusion. Chávez-Cartaya, R.E., DeSola, G.P., Wright, L., Jamieson, N.V., White, D.J. Transplantation (1995) [Pubmed]
  4. Polysaccharides of metaplastic mucosa and carcinoma of the gallbladder. Laitio, M., Terho, T. Lab. Invest. (1975) [Pubmed]
  5. Matrix metalloproteinase-2 (MMP-2) is associated with survival in breast carcinoma. Talvensaari-Mattila, A., Pääkkö, P., Turpeenniemi-Hujanen, T. Br. J. Cancer (2003) [Pubmed]
  6. Pancreatic carcinoma cells induce fibrosis by stimulating proliferation and matrix synthesis of stellate cells. Bachem, M.G., Schünemann, M., Ramadani, M., Siech, M., Beger, H., Buck, A., Zhou, S., Schmid-Kotsas, A., Adler, G. Gastroenterology (2005) [Pubmed]
  7. Transient expression of M-cell phenotype by enterocyte-like cells of the follicle-associated epithelium of mouse Peyer's patches. Sierro, F., Pringault, E., Assman, P.S., Kraehenbuhl, J.P., Debard, N. Gastroenterology (2000) [Pubmed]
  8. The C-X-C chemokine ENA-78 is preferentially expressed in intestinal epithelium in inflammatory bowel disease. Z'Graggen, K., Walz, A., Mazzucchelli, L., Strieter, R.M., Mueller, C. Gastroenterology (1997) [Pubmed]
  9. Epidemic of liver disease caused by hydrochlorofluorocarbons used as ozone-sparing substitutes of chlorofluorocarbons. Hoet, P., Graf, M.L., Bourdi, M., Pohl, L.R., Duray, P.H., Chen, W., Peter, R.M., Nelson, S.D., Verlinden, N., Lison, D. Lancet (1997) [Pubmed]
  10. Immunohistochemical expression of mammary tumor virus antigens in mammary glands of virgin mice, in relation to Mtv genes. Tsubura, A., Ueda, S., Shikata, N., Morii, S., Tanaka, H. Acta Pathol. Jpn. (1986) [Pubmed]
  11. Epidermal growth factor receptor blockade with C225 modulates proliferation, apoptosis, and radiosensitivity in squamous cell carcinomas of the head and neck. Huang, S.M., Bock, J.M., Harari, P.M. Cancer Res. (1999) [Pubmed]
  12. Expression of platelet-derived growth factor-beta receptors on human fibroblasts. Regulation by recombinant platelet-derived growth factor-BB, IL-1, and tumor necrosis factor-alpha. Tingström, A., Reuterdahl, C., Lindahl, P., Heldin, C.H., Rubin, K. J. Immunol. (1992) [Pubmed]
  13. Immunohistochemical detection of proliferating lipocytes in regenerating rat liver. Tanaka, Y., Mak, K.M., Lieber, C.S. J. Pathol. (1990) [Pubmed]
  14. Gastric and intestinal phenotypic marker expression in gastric carcinomas and recurrence pattern after surgery-immunohistochemical analysis of 213 lesions. Tajima, Y., Yamazaki, K., Nishino, N., Morohara, K., Yamazaki, T., Kaetsu, T., Suzuki, S., Kawamura, M., Kumagai, K., Kusano, M. Br. J. Cancer (2004) [Pubmed]
  15. Does Helicobacter pylori in the gastric stump increase the cancer risk after certain reconstruction types? Leivonen, M., Nordling, S., Haglund, C. Anticancer Res. (1997) [Pubmed]
  16. In vitro differentiation and calcification in a new clonal osteogenic cell line derived from newborn mouse calvaria. Sudo, H., Kodama, H.A., Amagai, Y., Yamamoto, S., Kasai, S. J. Cell Biol. (1983) [Pubmed]
  17. The nuclear form of phospholipid hydroperoxide glutathione peroxidase is a protein thiol peroxidase contributing to sperm chromatin stability. Conrad, M., Moreno, S.G., Sinowatz, F., Ursini, F., Kölle, S., Roveri, A., Brielmeier, M., Wurst, W., Maiorino, M., Bornkamm, G.W. Mol. Cell. Biol. (2005) [Pubmed]
  18. Mutations affecting somite formation and patterning in the zebrafish, Danio rerio. van Eeden, F.J., Granato, M., Schach, U., Brand, M., Furutani-Seiki, M., Haffter, P., Hammerschmidt, M., Heisenberg, C.P., Jiang, Y.J., Kane, D.A., Kelsh, R.N., Mullins, M.C., Odenthal, J., Warga, R.M., Allende, M.L., Weinberg, E.S., Nüsslein-Volhard, C. Development (1996) [Pubmed]
  19. Subcellular localization of (latent) transforming growth factor beta and the latent TGF-beta binding protein in rat hepatocytes and hepatic stellate cells. Roth-Eichhorn, S., Kühl, K., Gressner, A.M. Hepatology (1998) [Pubmed]
  20. In vitro secretion of gastrin, insulin, and glucagon in tissue cultures of pancreas from a child with neonatal intractable hypoglycemia. Hollande, E., Giron, B., Lehy, T., Accary, J.P., Rozé, C. Gastroenterology (1976) [Pubmed]
  21. Codistribution of heparan sulfate proteoglycan, laminin, and fibronectin in the extracellular matrix of normal rat kidney cells and their coordinate absence in transformed cells. Hayman, E.G., Oldberg, A., Martin, G.R., Ruoslahti, E. J. Cell Biol. (1982) [Pubmed]
  22. Multipotent stem cell involvement in megakaryoblastic leukemia: cytologic and cytogenetic evidence in 15 patients. Cuneo, A., Mecucci, C., Kerim, S., Vandenberghe, E., Dal Cin, P., Van Orshoven, A., Rodhain, J., Bosly, A., Michaux, J.L., Martiat, P. Blood (1989) [Pubmed]
  23. Sequential acetaldehyde production, lipid peroxidation, and fibrogenesis in micropig model of alcohol-induced liver disease. Niemelä, O., Parkkila, S., Ylä-Herttuala, S., Villanueva, J., Ruebner, B., Halsted, C.H. Hepatology (1995) [Pubmed]
  24. Hemoglobin-vesicles as oxygen carriers: influence on phagocytic activity and histopathological changes in reticuloendothelial system. Sakai, H., Horinouchi, H., Tomiyama, K., Ikeda, E., Takeoka, S., Kobayashi, K., Tsuchida, E. Am. J. Pathol. (2001) [Pubmed]
  25. Acute myeloid leukemia M4 with bone marrow eosinophilia (M4Eo) and inv(16)(p13q22) exhibits a specific immunophenotype with CD2 expression. Adriaansen, H.J., te Boekhorst, P.A., Hagemeijer, A.M., van der Schoot, C.E., Delwel, H.R., van Dongen, J.J. Blood (1993) [Pubmed]
  26. Overexpression of hyperactive integrin-linked kinase leads to increased cellular radiosensitivity. Cordes, N. Cancer Res. (2004) [Pubmed]
  27. Menstrual stage-specific expression of epidermal growth factor and transforming growth factor-alpha in human oviduct epithelium and their role in early embryogenesis. Morishige, K., Kurachi, H., Amemiya, K., Adachi, H., Adachi, K., Sakoyama, Y., Miyake, A., Tanizawa, O. Endocrinology (1993) [Pubmed]
  28. p22/WAF1 expression in human colorectal carcinoma: association with p53, transcription factor AP-2 and prognosis. Ropponen, K.M., Kellokoski, J.K., Lipponen, P.K., Pietiläinen, T., Eskelinen, M.J., Alhava, E.M., Kosma, V.M. Br. J. Cancer (1999) [Pubmed]
  29. Induced expression of adhesion molecules following focal brain ischemia. Wang, X., Feuerstein, G.Z. J. Neurotrauma (1995) [Pubmed]
  30. The influence of prophylactic immunosuppressive regimens on natural killer and lymphokine-activated killer cells in renal transplant recipients. Alamartine, E., Sabido, O., Berthoux, F.C. Transplantation (1990) [Pubmed]
  31. Mitochondrial carbonic anhydrase in the nervous system: expression in neuronal and glial cells. Ghandour, M.S., Parkkila, A.K., Parkkila, S., Waheed, A., Sly, W.S. J. Neurochem. (2000) [Pubmed]
  32. Melatonin reduces disseminate neuronal death after mild focal ischemia in mice via inhibition of caspase-3 and is suitable as an add-on treatment to tissue-plasminogen activator. Kilic, E., Kilic, U., Yulug, B., Hermann, D.M., Reiter, R.J. J. Pineal Res. (2004) [Pubmed]
  33. A quantitative in situ hybridization and polymerase chain reaction study of microglial-macrophage expression of interleukin-1beta mRNA following permanent middle cerebral artery occlusion in mice. Clausen, B.H., Lambertsen, K.L., Meldgaard, M., Finsen, B. Neuroscience (2005) [Pubmed]
  34. Reduction of apoptosis and proliferation in endometriosis. Béliard, A., Noël, A., Foidart, J.M. Fertil. Steril. (2004) [Pubmed]
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