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Gene Review:

GPR75 - G protein-coupled receptor 75

Homo sapiens

Synonyms: GPRchr2, WI-31133, WI31133

Sauer, C.G. et al., Ignatov, A. et al.

Ignatov, Robert, Gregory-Evans, Schaller,

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Disease relevance of GPR75

Evaluation of the G protein coupled receptor-75 (GPR75) in age related macular degeneration [1].

High impact information on GPR75

RANTES stimulates Ca(2+) mobilization and inositol trisphosphate (IP(3)) formation in cells transfected with G protein-coupled receptor 75 [2].
CONCLUSION: The presence of six potential pathogenic variants in a cohort of 535 AMD patients alone does not provide statistically significant evidence for the association of sequence variation in GPR75 with genetic predisposition to AMD [1].
METHODS: Northern blot and RT-PCR analyses confirmed preferential retinal expression of the gene, which encodes a G protein coupled receptor, GPR75 [1].

References

Evaluation of the G protein coupled receptor-75 (GPR75) in age related macular degeneration. Sauer, C.G., White, K., Stöhr, H., Grimm, T., Hutchinson, A., Bernstein, P.S., Lewis, R.A., Simonelli, F., Pauleikhoff, D., Allikmets, R., Weber, B.H. The British journal of ophthalmology. (2001) [Pubmed]
RANTES stimulates Ca(2+) mobilization and inositol trisphosphate (IP(3)) formation in cells transfected with G protein-coupled receptor 75. Ignatov, A., Robert, J., Gregory-Evans, C., Schaller, H.C. Br. J. Pharmacol. (2006) [Pubmed]

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GPR75	Bos taurus
gpr75	Danio rerio
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gpr75	Xenopus (Silurana) tropicalis

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