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MeSH Review

Macular Degeneration

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Disease relevance of Macular Degeneration


Psychiatry related information on Macular Degeneration


High impact information on Macular Degeneration


Chemical compound and disease context of Macular Degeneration


Biological context of Macular Degeneration


Anatomical context of Macular Degeneration


Gene context of Macular Degeneration


Analytical, diagnostic and therapeutic context of Macular Degeneration


  1. RhoB controls Akt trafficking and stage-specific survival of endothelial cells during vascular development. Adini, I., Rabinovitz, I., Sun, J.F., Prendergast, G.C., Benjamin, L.E. Genes Dev. (2003) [Pubmed]
  2. Long-term preservation of cortically dependent visual function in RCS rats by transplantation. Coffey, P.J., Girman, S., Wang, S.M., Hetherington, L., Keegan, D.J., Adamson, P., Greenwood, J., Lund, R.D. Nat. Neurosci. (2002) [Pubmed]
  3. Refining the locus for Best vitelliform macular dystrophy and mutation analysis of the candidate gene ROM1. Nichols, B.E., Bascom, R., Litt, M., McInnes, R., Sheffield, V.C., Stone, E.M. Am. J. Hum. Genet. (1994) [Pubmed]
  4. A second locus for familial high myopia maps to chromosome 12q. Young, T.L., Ronan, S.M., Alvear, A.B., Wildenberg, S.C., Oetting, W.S., Atwood, L.D., Wilkin, D.J., King, R.A. Am. J. Hum. Genet. (1998) [Pubmed]
  5. Overexpression of vascular endothelial growth factor (VEGF) in the retinal pigment epithelium leads to the development of choroidal neovascularization. Spilsbury, K., Garrett, K.L., Shen, W.Y., Constable, I.J., Rakoczy, P.E. Am. J. Pathol. (2000) [Pubmed]
  6. Association of dyslipidemia and effects of statins on nonmacrovascular diseases. Baghdasarian, S.B., Jneid, H., Hoogwerf, B.J. Clinical therapeutics. (2004) [Pubmed]
  7. Inhibition of interleukin-1-induced uveitis and corneal fibroblast proliferation by interleukin-1 blockers. Chiou, G.C., Xuan, B., Liu, Q., Yamasaki, T., Okawara, T. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics. (2000) [Pubmed]
  8. Variation in factor B (BF) and complement component 2 (C2) genes is associated with age-related macular degeneration. Gold, B., Merriam, J.E., Zernant, J., Hancox, L.S., Taiber, A.J., Gehrs, K., Cramer, K., Neel, J., Bergeron, J., Barile, G.R., Smith, R.T., Hageman, G.S., Dean, M., Allikmets, R., Chang, S., Yannuzzi, L.A., Merriam, J.C., Barbazetto, I., Lerner, L.E., Russell, S., Hoballah, J., Hageman, J., Stockman, H. Nat. Genet. (2006) [Pubmed]
  9. A 5-bp deletion in ELOVL4 is associated with two related forms of autosomal dominant macular dystrophy. Zhang, K., Kniazeva, M., Han, M., Li, W., Yu, Z., Yang, Z., Li, Y., Metzker, M.L., Allikmets, R., Zack, D.J., Kakuk, L.E., Lagali, P.S., Wong, P.W., MacDonald, I.M., Sieving, P.A., Figueroa, D.J., Austin, C.P., Gould, R.J., Ayyagari, R., Petrukhin, K. Nat. Genet. (2001) [Pubmed]
  10. Biochemical defects in ABCR protein variants associated with human retinopathies. Sun, H., Smallwood, P.M., Nathans, J. Nat. Genet. (2000) [Pubmed]
  11. Protection of Rpe65-deficient mice identifies rhodopsin as a mediator of light-induced retinal degeneration. Grimm, C., Wenzel, A., Hafezi, F., Yu, S., Redmond, T.M., Remé, C.E. Nat. Genet. (2000) [Pubmed]
  12. Identification of the gene responsible for Best macular dystrophy. Petrukhin, K., Koisti, M.J., Bakall, B., Li, W., Xie, G., Marknell, T., Sandgren, O., Forsman, K., Holmgren, G., Andreasson, S., Vujic, M., Bergen, A.A., McGarty-Dugan, V., Figueroa, D., Austin, C.P., Metzker, M.L., Caskey, C.T., Wadelius, C. Nat. Genet. (1998) [Pubmed]
  13. Treatment with isotretinoin inhibits lipofuscin accumulation in a mouse model of recessive Stargardt's macular degeneration. Radu, R.A., Mata, N.L., Nusinowitz, S., Liu, X., Sieving, P.A., Travis, G.H. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  14. The specific binding of retinoic acid to RPE65 and approaches to the treatment of macular degeneration. Gollapalli, D.R., Rando, R.R. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  15. Altered retinoid homeostasis catalyzed by a nicotine metabolite: implications in macular degeneration and normal development. Brogan, A.P., Dickerson, T.J., Boldt, G.E., Janda, K.D. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  16. Inhibition of the visual cycle in vivo by 13-cis retinoic acid protects from light damage and provides a mechanism for night blindness in isotretinoin therapy. Sieving, P.A., Chaudhry, P., Kondo, M., Provenzano, M., Wu, D., Carlson, T.J., Bush, R.A., Thompson, D.A. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  17. A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration. Hageman, G.S., Anderson, D.H., Johnson, L.V., Hancox, L.S., Taiber, A.J., Hardisty, L.I., Hageman, J.L., Stockman, H.A., Borchardt, J.D., Gehrs, K.M., Smith, R.J., Silvestri, G., Russell, S.R., Klaver, C.C., Barbazetto, I., Chang, S., Yannuzzi, L.A., Barile, G.R., Merriam, J.C., Smith, R.T., Olsh, A.K., Bergeron, J., Zernant, J., Merriam, J.E., Gold, B., Dean, M., Allikmets, R. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  18. The oxidative stressor arsenite activates vascular endothelial growth factor mRNA transcription by an ATF4-dependent mechanism. Roybal, C.N., Hunsaker, L.A., Barbash, O., Vander Jagt, D.L., Abcouwer, S.F. J. Biol. Chem. (2005) [Pubmed]
  19. Vascular endothelial growth factors and angiogenesis in eye disease. Witmer, A.N., Vrensen, G.F., Van Noorden, C.J., Schlingemann, R.O. Progress in retinal and eye research. (2003) [Pubmed]
  20. Genotype-phenotype analysis of ABCR variants in macular degeneration probands and siblings. Bernstein, P.S., Leppert, M., Singh, N., Dean, M., Lewis, R.A., Lupski, J.R., Allikmets, R., Seddon, J.M. Invest. Ophthalmol. Vis. Sci. (2002) [Pubmed]
  21. Effect of short-term, high-dose retinol on dark adaptation in aging and early age-related maculopathy. Owsley, C., McGwin, G., Jackson, G.R., Heimburger, D.C., Piyathilake, C.J., Klein, R., White, M.F., Kallies, K. Invest. Ophthalmol. Vis. Sci. (2006) [Pubmed]
  22. Expressions of angiopoietins and Tie2 in human choroidal neovascular membranes. Otani, A., Takagi, H., Oh, H., Koyama, S., Matsumura, M., Honda, Y. Invest. Ophthalmol. Vis. Sci. (1999) [Pubmed]
  23. Compartmental analysis of taurine transport to the outer retina in the bovine eye. Hillenkamp, J., Hussain, A.A., Jackson, T.L., Constable, P.A., Cunningham, J.R., Marshall, J. Invest. Ophthalmol. Vis. Sci. (2004) [Pubmed]
  24. Combined HPLC-MS and HPLC-NMR on-line coupling for the separation and determination of lutein and zeaxanthin stereoisomers in spinach and in retina. Dachtler, M., Glaser, T., Kohler, K., Albert, K. Anal. Chem. (2001) [Pubmed]
  25. Autoradiographic studies of aged primate macular retinal pigment epithelium. Hirata, A., Feeney-Burns, L. Invest. Ophthalmol. Vis. Sci. (1992) [Pubmed]
  26. Identification of an HLA-A*0201 cytotoxic T lymphocyte epitope specific to the endothelial antigen Tie-2. Ramage, J.M., Metheringham, R., Conn, A., Spendlove, I., Moss, R.S., Patton, D.T., Murray, J.C., Rees, R.C., Durrant, L.G. Int. J. Cancer (2004) [Pubmed]
  27. The biology of VEGF and its receptors. Ferrara, N., Gerber, H.P., LeCouter, J. Nat. Med. (2003) [Pubmed]
  28. An animal model of age-related macular degeneration in senescent Ccl-2- or Ccr-2-deficient mice. Ambati, J., Anand, A., Fernandez, S., Sakurai, E., Lynn, B.C., Kuziel, W.A., Rollins, B.J., Ambati, B.K. Nat. Med. (2003) [Pubmed]
  29. Aberrant accumulation of EFEMP1 underlies drusen formation in Malattia Leventinese and age-related macular degeneration. Marmorstein, L.Y., Munier, F.L., Arsenijevic, Y., Schorderet, D.F., McLaughlin, P.J., Chung, D., Traboulsi, E., Marmorstein, A.D. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  30. Disease mechanisms in late-onset retinal macular degeneration associated with mutation in C1QTNF5. Shu, X., Tulloch, B., Lennon, A., Vlachantoni, D., Zhou, X., Hayward, C., Wright, A.F. Hum. Mol. Genet. (2006) [Pubmed]
  31. Dominant negative mechanism underlies autosomal dominant Stargardt-like macular dystrophy linked to mutations in ELOVL4. Grayson, C., Molday, R.S. J. Biol. Chem. (2005) [Pubmed]
  32. RNA interference as a gene-specific approach for molecular medicine. Grünweller, A., Hartmann, R.K. Current medicinal chemistry. (2005) [Pubmed]
  33. Phenotypic variation of retinal pigment epithelium in age-related macular degeneration. Guidry, C., Medeiros, N.E., Curcio, C.A. Invest. Ophthalmol. Vis. Sci. (2002) [Pubmed]
  34. Agreement among ophthalmologists in evaluating fluorescein angiograms in patients with neovascular age-related macular degeneration for photodynamic therapy eligibility (FLAP-study). Holz, F.G., Jorzik, J., Schutt, F., Flach, U., Unnebrink, K. Ophthalmology (2003) [Pubmed]
  35. Growth rate of subretinal neovascularization in age-related macular degeneration. Vander, J.F., Morgan, C.M., Schatz, H. Ophthalmology (1989) [Pubmed]
  36. Esterification does not impair lutein bioavailability in humans. Bowen, P.E., Herbst-Espinosa, S.M., Hussain, E.A., Stacewicz-Sapuntzakis, M. J. Nutr. (2002) [Pubmed]
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