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Gene Review

Obq1  -  obesity QTL 1

Mus musculus

 
 
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High impact information on Obq1

  • Although the main effect of the diabetogenic QTL on chromosome 1 was on rapid growth rather than adiposity, it interacted epistatically with the obesity QTL on chromosome 12 to increase plasma glucose levels [1].
  • A NON QTL on chromosome 14 interacted epistatically with the NZO obesity QTL on chromosome 12 to increase adiposity [1].
  • Characterisation of the mouse diabetes susceptibilty locus Nidd/SJL: islet cell destruction, interaction with the obesity QTL Nob1, and effect of dietary fat [2].
  • A second obesity QTL (Obq4) maps to the centromeric end of Chromosome 17, with a lod score peak of 4.6 at D17Mit143 [3].
  • We have further mapped this QTL by progeny testing of recombinants, produced from crosses between the F-line and congenic F(chrl5L) mice, showing that the Fob3 QTL region is a composite of at least two smaller effect QTL-the proximal QTL Fob3a is a late-onset obesity QTL, whereas the distal Fob3b is an early-onset obesity QTL [4].
 

Other interactions of Obq1

References

  1. Maternal environment and genotype interact to establish diabesity in mice. Reifsnyder, P.C., Churchill, G., Leiter, E.H. Genome Res. (2000) [Pubmed]
  2. Characterisation of the mouse diabetes susceptibilty locus Nidd/SJL: islet cell destruction, interaction with the obesity QTL Nob1, and effect of dietary fat. Plum, L., Giesen, K., Kluge, R., Junger, E., Linnartz, K., Schürmann, A., Becker, W., Joost, H.G. Diabetologia (2002) [Pubmed]
  3. Obesity QTLs on mouse chromosomes 2 and 17. Taylor, B.A., Phillips, S.J. Genomics (1997) [Pubmed]
  4. Genetic complexity of an obesity QTL ( Fob3) revealed by detailed genetic mapping. Stylianou, I.M., Christians, J.K., Keightley, P.D., Bünger, L., Clinton, M., Bulfield, G., Horvat, S. Mamm. Genome (2004) [Pubmed]
 
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