Gene Review:
Adip1 - adiposity 1
Mus musculus
Ishihara,
Kanatani,
Mashiko,
Tanaka,
Hidaka,
Gomori,
Iwaasa,
Murai,
Egashira,
Murai,
Mitobe,
Matsushita,
Okamoto,
Sato,
Jitsuoka,
Fukuroda,
Ohe,
Guan,
Macneil,
Van der Ploeg,
Nishikibe,
Ishii,
Ihara,
Fukami,
Cheverud,
Vaughn,
Pletscher,
Peripato,
Adams,
Erikson,
King-Ellison,
Gao,
Mezei,
Nie,
Rao,
Choi,
Bechmann,
Leranth,
Toran-Allerand,
Priest,
Roberts,
Gao,
Mobbs,
Shulman,
Diano,
Horvath,
Zemel,
Poirier,
Shapiro,
Kim,
Lazar,
Horvath,
Gao,
Memisoglu,
Hu,
Hankinson,
Manson,
De Vivo,
Willett,
Hunter,
Brown,
Koza,
Everett,
Reitman,
Marshall,
Fahien,
Kozak,
MacDonald,
Zemel,
Shi,
Greer,
Dirienzo,
Zemel,
- Genetic architecture of adiposity in the cross of LG/J and SM/J inbred mice. Cheverud, J.M., Vaughn, T.T., Pletscher, L.S., Peripato, A.C., Adams, E.S., Erikson, C.F., King-Ellison, K.J. Mamm. Genome (2001)
- Small molecule insulin mimetics reduce food intake and body weight and prevent development of obesity. Air, E.L., Strowski, M.Z., Benoit, S.C., Conarello, S.L., Salituro, G.M., Guan, X.M., Liu, K., Woods, S.C., Zhang, B.B. Nat. Med. (2002)
- Neuromedin U has a novel anorexigenic effect independent of the leptin signaling pathway. Hanada, R., Teranishi, H., Pearson, J.T., Kurokawa, M., Hosoda, H., Fukushima, N., Fukue, Y., Serino, R., Fujihara, H., Ueta, Y., Ikawa, M., Okabe, M., Murakami, N., Shirai, M., Yoshimatsu, H., Kangawa, K., Kojima, M. Nat. Med. (2004)
- Absence of ghrelin protects against early-onset obesity. Wortley, K.E., del Rincon, J.P., Murray, J.D., Garcia, K., Iida, K., Thorner, M.O., Sleeman, M.W. J. Clin. Invest. (2005)
- Leptin selectively decreases visceral adiposity and enhances insulin action. Barzilai, N., Wang, J., Massilon, D., Vuguin, P., Hawkins, M., Rossetti, L. J. Clin. Invest. (1997)
- Mice lacking ghrelin receptors resist the development of diet-induced obesity. Zigman, J.M., Nakano, Y., Coppari, R., Balthasar, N., Marcus, J.N., Lee, C.E., Jones, J.E., Deysher, A.E., Waxman, A.R., White, R.D., Williams, T.D., Lachey, J.L., Seeley, R.J., Lowell, B.B., Elmquist, J.K. J. Clin. Invest. (2005)
- Input organization and plasticity of hypocretin neurons: possible clues to obesity's association with insomnia. Horvath, T.L., Gao, X.B. Cell metabolism. (2005)
- Peroxisome-proliferator-activated receptor delta activates fat metabolism to prevent obesity. Wang, Y.X., Lee, C.H., Tiep, S., Yu, R.T., Ham, J., Kang, H., Evans, R.M. Cell (2003)
- Anorectic estrogen mimics leptin's effect on the rewiring of melanocortin cells and Stat3 signaling in obese animals. Gao, Q., Mezei, G., Nie, Y., Rao, Y., Choi, C.S., Bechmann, I., Leranth, C., Toran-Allerand, D., Priest, C.A., Roberts, J.L., Gao, X.B., Mobbs, C., Shulman, G.I., Diano, S., Horvath, T.L. Nat. Med. (2007)
- Neuronal PTP1B regulates body weight, adiposity and leptin action. Bence, K.K., Delibegovic, M., Xue, B., Gorgun, C.Z., Hotamisligil, G.S., Neel, B.G., Kahn, B.B. Nat. Med. (2006)
- A central role for JNK in obesity and insulin resistance. Hirosumi, J., Tuncman, G., Chang, L., Görgün, C.Z., Uysal, K.T., Maeda, K., Karin, M., Hotamisligil, G.S. Nature (2002)
- Prevention of obesity in mice by antisense oligonucleotide inhibitors of stearoyl-CoA desaturase-1. Jiang, G., Li, Z., Liu, F., Ellsworth, K., Dallas-Yang, Q., Wu, M., Ronan, J., Esau, C., Murphy, C., Szalkowski, D., Bergeron, R., Doebber, T., Zhang, B.B. J. Clin. Invest. (2005)
- Adipocyte-selective reduction of the leptin receptors induced by antisense RNA leads to increased adiposity, dyslipidemia, and insulin resistance. Huan, J.N., Li, J., Han, Y., Chen, K., Wu, N., Zhao, A.Z. J. Biol. Chem. (2003)
- A novel missense substitution (Val1483Ile) in the fatty acid synthase gene (FAS) is associated with percentage of body fat and substrate oxidation rates in nondiabetic Pima Indians. Kovacs, P., Harper, I., Hanson, R.L., Infante, A.M., Bogardus, C., Tataranni, P.A., Baier, L.J. Diabetes (2004)
- Role of calcium and dairy products in energy partitioning and weight management. Zemel, M.B. Am. J. Clin. Nutr. (2004)
- Lipocalin-2 is an inflammatory marker closely associated with obesity, insulin resistance, and hyperglycemia in humans. Wang, Y., Lam, K.S., Kraegen, E.W., Sweeney, G., Zhang, J., Tso, A.W., Chow, W.S., Wat, N.M., Xu, J.Y., Hoo, R.L., Xu, A. Clin. Chem. (2007)
- Role of the Y5 neuropeptide Y receptor in feeding and obesity. Marsh, D.J., Hollopeter, G., Kafer, K.E., Palmiter, R.D. Nat. Med. (1998)
- The hormone resistin links obesity to diabetes. Steppan, C.M., Bailey, S.T., Bhat, S., Brown, E.J., Banerjee, R.R., Wright, C.M., Patel, H.R., Ahima, R.S., Lazar, M.A. Nature (2001)
- Role of leptin in the neuroendocrine response to fasting. Ahima, R.S., Prabakaran, D., Mantzoros, C., Qu, D., Lowell, B., Maratos-Flier, E., Flier, J.S. Nature (1996)
- Targeted expression of a toxin gene to adipose tissue: transgenic mice resistant to obesity. Ross, S.R., Graves, R.A., Spiegelman, B.M. Genes Dev. (1993)
- Thermoregulatory and metabolic phenotypes of mice lacking noradrenaline and adrenaline. Thomas, S.A., Palmiter, R.D. Nature (1997)
- Insulin and leptin revisited: adiposity signals with overlapping physiological and intracellular signaling capabilities. Niswender, K.D., Schwartz, M.W. Frontiers in neuroendocrinology. (2003)
- Increased insulin sensitivity and reduced adiposity in phosphatidylinositol 5-phosphate 4-kinase beta-/- mice. Lamia, K.A., Peroni, O.D., Kim, Y.B., Rameh, L.E., Kahn, B.B., Cantley, L.C. Mol. Cell. Biol. (2004)
- Normal thyroid thermogenesis but reduced viability and adiposity in mice lacking the mitochondrial glycerol phosphate dehydrogenase. Brown, L.J., Koza, R.A., Everett, C., Reitman, M.L., Marshall, L., Fahien, L.A., Kozak, L.P., MacDonald, M.J. J. Biol. Chem. (2002)
- Skeletal muscle respiratory uncoupling prevents diet-induced obesity and insulin resistance in mice. Li, B., Nolte, L.A., Ju, J.S., Han, D.H., Coleman, T., Holloszy, J.O., Semenkovich, C.F. Nat. Med. (2000)
- Effects of zidovudine, stavudine and beta-aminoisobutyric acid on lipid homeostasis in mice: possible role in human fat wasting. Maisonneuve, C., Igoudjil, A., Begriche, K., Lettéron, P., Guimont, M.C., Bastin, J., Laigneau, J.P., Pessayre, D., Fromenty, B. Antivir. Ther. (Lond.) (2004)
- Interaction between a peroxisome proliferator-activated receptor gamma gene polymorphism and dietary fat intake in relation to body mass. Memisoglu, A., Hu, F.B., Hankinson, S.E., Manson, J.E., De Vivo, I., Willett, W.C., Hunter, D.J. Hum. Mol. Genet. (2003)
- Role of adipocyte-derived factors in enhancing insulin signaling in skeletal muscle and white adipose tissue of mice lacking Acyl CoA:diacylglycerol acyltransferase 1. Chen, H.C., Rao, M., Sajan, M.P., Standaert, M., Kanoh, Y., Miura, A., Farese, R.V., Farese, R.V. Diabetes (2004)
- Central infusion of histamine reduces fat accumulation and upregulates UCP family in leptin-resistant obese mice. Masaki, T., Yoshimatsu, H., Chiba, S., Watanabe, T., Sakata, T. Diabetes (2001)
- A neuropeptide Y Y5 antagonist selectively ameliorates body weight gain and associated parameters in diet-induced obese mice. Ishihara, A., Kanatani, A., Mashiko, S., Tanaka, T., Hidaka, M., Gomori, A., Iwaasa, H., Murai, N., Egashira, S., Murai, T., Mitobe, Y., Matsushita, H., Okamoto, O., Sato, N., Jitsuoka, M., Fukuroda, T., Ohe, T., Guan, X., Macneil, D.J., Van der Ploeg, L.H., Nishikibe, M., Ishii, Y., Ihara, M., Fukami, T. Proc. Natl. Acad. Sci. U.S.A. (2006)
- Attenuation of diet-induced weight gain and adiposity through increased energy expenditure in mice lacking angiotensin II type 1a receptor. Kouyama, R., Suganami, T., Nishida, J., Tanaka, M., Toyoda, T., Kiso, M., Chiwata, T., Miyamoto, Y., Yoshimasa, Y., Fukamizu, A., Horiuchi, M., Hirata, Y., Ogawa, Y. Endocrinology (2005)
- Synergistic effects of Y2 and Y4 receptors on adiposity and bone mass revealed in double knockout mice. Sainsbury, A., Baldock, P.A., Schwarzer, C., Ueno, N., Enriquez, R.F., Couzens, M., Inui, A., Herzog, H., Gardiner, E.M. Mol. Cell. Biol. (2003)
- Elevated sensitivity to diet-induced obesity and insulin resistance in mice lacking 4E-BP1 and 4E-BP2. Le Bacquer, O., Petroulakis, E., Paglialunga, S., Poulin, F., Richard, D., Cianflone, K., Sonenberg, N. J. Clin. Invest. (2007)
- CCR2 modulates inflammatory and metabolic effects of high-fat feeding. Weisberg, S.P., Hunter, D., Huber, R., Lemieux, J., Slaymaker, S., Vaddi, K., Charo, I., Leibel, R.L., Ferrante, A.W. J. Clin. Invest. (2006)
- Lower blood glucose, hyperglucagonemia, and pancreatic alpha cell hyperplasia in glucagon receptor knockout mice. Gelling, R.W., Du, X.Q., Dichmann, D.S., Romer, J., Huang, H., Cui, L., Obici, S., Tang, B., Holst, J.J., Fledelius, C., Johansen, P.B., Rossetti, L., Jelicks, L.A., Serup, P., Nishimura, E., Charron, M.J. Proc. Natl. Acad. Sci. U.S.A. (2003)
- Obesity resistance and enhanced glucose metabolism in mice transplanted with white adipose tissue lacking acyl CoA:diacylglycerol acyltransferase 1. Chen, H.C., Jensen, D.R., Myers, H.M., Eckel, R.H., Farese, R.V. J. Clin. Invest. (2003)
- Susceptibility to Induced and Spontaneous Carcinogenesis Is Increased in Fatless A-ZIP/F-1 but not in Obese ob/ob Mice. Ablamunits, V., Cohen, Y., Brazee, I.B., Gaetz, H.P., Vinson, C., Klebanov, S. Cancer Res. (2006)
- Regulation of adiposity by dietary calcium. Zemel, M.B., Shi, H., Greer, B., Dirienzo, D., Zemel, P.C. FASEB J. (2000)
- Nutritional Supplementation With trans-10, cis-12-Conjugated Linoleic Acid Induces Inflammation of White Adipose Tissue. Poirier, H., Shapiro, J.S., Kim, R.J., Lazar, M.A. Diabetes (2006)