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Gene Review

Lbw2  -  lupus NZB x NZW 2

Mus musculus

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Disease relevance of Lbw2


High impact information on Lbw2

  • Lack of the NZB Lbw2 indeed reduced mortality and glomerulonephritis, but not serum levels of total and anti-DNA IgG Abs [2].
  • These findings establish the importance of Lbw2 in the BWF1 hybrid and indicate that Lbw2, by enhancing B cell hyperactivity, promotes the early polyclonal activation of B cells and subsequent production of autoantibodies [2].
  • Analysis of NZB x SNF1 backcross mice has recently revealed the existence of four dominant SWR loci (H2 on Chr 17, Swrl-1 on Chr 1, Swrl-2 on Chr 14 and Swrl-3 on Chr 18), and two NZB loci (Nba1 and Lbw2/Sbw2, both on Chr 4) conferring lupus susceptibility [3].

Biological context of Lbw2


  1. Lupus susceptibility loci in New Zealand mice. Kono, D.H., Burlingame, R.W., Owens, D.G., Kuramochi, A., Balderas, R.S., Balomenos, D., Theofilopoulos, A.N. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  2. Autoimmune alterations induced by the New Zealand Black Lbw2 locus in BWF1 mice. Haraldsson, M.K., dela Paz, N.G., Kuan, J.G., Gilkeson, G.S., Theofilopoulos, A.N., Kono, D.H. J. Immunol. (2005) [Pubmed]
  3. Dominant NZB contributions to lupus in the (SWR x NZB)F1 model. Xie, S., Chang, S.H., Sedrak, P., Kaliyaperumal, A., Datta, S.K., Mohan, C. Genes Immun. (2002) [Pubmed]
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