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Gene Review

Calca  -  calcitonin/calcitonin-related polypeptide,...

Mus musculus

Synonyms: Alpha-type CGRP, CA, CGRP-1, CGRP-I, CGRP1, ...
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Disease relevance of Calca


Psychiatry related information on Calca


High impact information on Calca


Chemical compound and disease context of Calca

  • Concentrations of immunoreactive SP, NKA, and CGRP were measured in extracts of the eczema ears (n = 26), whereas extracts of the opposite ears were used as controls [4].
  • Hypercalcemia evoked by vitamin D2 treatment, which is known to degranulate thyroid C cells, reduced the thyroid content of both CGRP and CT [2].
  • Levels of CGRP messenger RNA in dorsal root ganglion neurons isolated from female CGRP(+/+) mice were decreased by ovariectomy, and these decreases were reversed by estradiol replacement [12].
  • Conversely, the selective NK2, NK3, and calcitonin gene-related peptide (CGRP) CGRP(8-37) receptor antagonists all failed to interfere with PGE2-induced paw edema [13].
  • Effects of phorbol esters and pertussis toxin on calcitonin-stimulated accumulation of cyclic AMP in neonatal mouse calvarial bones [14].

Biological context of Calca

  • We have recently described an unexpected high bone mass phenotype in mice carrying a targeted deletion of the Calca gene [15].
  • MATERIALS AND METHODS: Bones from Calca(-/-) mice, alphaCGRP(-/-) mice, and their corresponding wildtype controls were analyzed using radiography, muCT imaging, and undecalcified histology [15].
  • Acute administration of a CGRP receptor antagonist increases the blood pressure (BP) in several models of hypertension, which indicates that this potent vasodilator plays a counterregulatory role to attenuate the BP increase in these settings [16].
  • These results indicate for the first time that alpha-CGRP may be involved in the long-term regulation of resting BP and suggest that these mice are particularly sensitive to challenges to BP homeostasis because of the loss of a compensatory vasodilator mechanism [16].
  • In this study, we have characterized binding sites for 125I-salmon calcitonin (125I-sCT), 125I-rat alpha-calcitonin gene-related peptide (125I-CGRP), and 125I-rat amylin in alpha-TSH cells [17].

Anatomical context of Calca


Associations of Calca with chemical compounds

  • At birth, transgenic DRG showed increased neuron numbers, and displayed a normal proportion of neurons expressing substance P, calcitonin gene-related peptide and the NT3 receptor trkC [21].
  • After 4 weeks of streptozotocin-induced diabetes, the number of immunoreactive CGRP A-cells was reduced from 692 +/- 122 to 489 +/- 125 (P = 0.004) in p75(+/+) mice on the noncrushed side [19].
  • Capsaicin, heat and pH 5.2 were able to induce significant increases in calcitonin gene related peptide (CGRP) release (14.6-, 5.1-, and 2.3-fold over baseline), however, only capsaicin induced a significant increase in substance P (SP) levels (1.8-fold over baseline) [22].
  • This diminution correlated with the loss of CGRP inhibition of acetylcholine-induced contractions observed in the force experiments [23].
  • Substance P, calcitonin gene related peptide and PGE2 co-released from the mouse colon: a new model to study nociceptive and inflammatory responses in viscera, in vitro [22].

Physical interactions of Calca


Co-localisations of Calca

  • SP colocalized with CGRP in some of those axonal boutons and fibres [27].

Regulatory relationships of Calca

  • These results suggest that CT down-regulates C1a-CTR mRNA expression at least in part by a transcriptional mechanism, thereby contributing to the ligand-induced desensitization in cells of the osteoclast lineage [28].
  • Calcitonin gene-related peptide enhanced IFN-gamma secretion in susceptible mouse splenocytes at 10(-6), 10(-7) and 10(-9) M, as did VIP at 10(-10) M and NPY at 10(-7) M [29].
  • Blockade of protein synthesis with cycloheximide inhibited Ca2+ uptake induced by PTH but not that stimulated by calcitonin [30].
  • In contrast, RIA demonstrated a lower (p < .05) concentration of CGRP in the inflamed ears compared with controls and a tendency for substance P to decrease in concentration in eczematous ears versus controls [31].
  • Expression of dopaminergic phenotypes in the mouse olfactory bulb induced by the calcitonin gene-related peptide [32].

Other interactions of Calca


Analytical, diagnostic and therapeutic context of Calca


  1. Effects of continuous calcitonin treatment on osteoclast-like cell development and calcitonin receptor expression in mouse bone marrow cultures. Ikegame, M., Rakopoulos, M., Martin, T.J., Moseley, J.M., Findlay, D.M. J. Bone Miner. Res. (1996) [Pubmed]
  2. Calcitonin gene-related peptide in thyroid nerve fibers and C cells: effects on thyroid hormone secretion and response to hypercalcemia. Grunditz, T., Ekman, R., Håkanson, R., Rerup, C., Sundler, F., Uddman, R. Endocrinology (1986) [Pubmed]
  3. Arthritic calcitonin/alpha calcitonin gene-related peptide knockout mice have reduced nociceptive hypersensitivity. Zhang, L., Hoff, A.O., Wimalawansa, S.J., Cote, G.J., Gagel, R.F., Westlund, K.N. Pain (2001) [Pubmed]
  4. Tachykinins and calcitonin gene-related peptide in oxazolone-induced allergic contact dermatitis in mice. Ek, L., Theodorsson, E. J. Invest. Dermatol. (1990) [Pubmed]
  5. Polyethylene particle-induced bone resorption in alpha-calcitonin gene-related peptide-deficient mice. Wedemeyer, C., Neuerburg, C., Pfeiffer, A., Heckelei, A., Bylski, D., von Knoch, F., Schinke, T., Hilken, G., Gosheger, G., von Knoch, M., Löer, F., Saxler, G. J. Bone Miner. Res. (2007) [Pubmed]
  6. Altered neuroadaptation in opiate dependence and neurogenic inflammatory nociception in alpha CGRP-deficient mice. Salmon, A.M., Damaj, M.I., Marubio, L.M., Epping-Jordan, M.P., Merlo-Pich, E., Changeux, J.P. Nat. Neurosci. (2001) [Pubmed]
  7. Nerve growth factor prevents experimental cisplatin neuropathy. Apfel, S.C., Arezzo, J.C., Lipson, L., Kessler, J.A. Ann. Neurol. (1992) [Pubmed]
  8. Follicular cells of the thyroid gland require Pax8 gene function. Mansouri, A., Chowdhury, K., Gruss, P. Nat. Genet. (1998) [Pubmed]
  9. Lack of neurotrophin-3 leads to deficiencies in the peripheral nervous system and loss of limb proprioceptive afferents. Ernfors, P., Lee, K.F., Kucera, J., Jaenisch, R. Cell (1994) [Pubmed]
  10. Neuron-specific alternative RNA processing in transgenic mice expressing a metallothionein-calcitonin fusion gene. Crenshaw, E.B., Russo, A.F., Swanson, L.W., Rosenfeld, M.G. Cell (1987) [Pubmed]
  11. Osteoclasts degrade endosteal components and promote mobilization of hematopoietic progenitor cells. Kollet, O., Dar, A., Shivtiel, S., Kalinkovich, A., Lapid, K., Sztainberg, Y., Tesio, M., Samstein, R.M., Goichberg, P., Spiegel, A., Elson, A., Lapidot, T. Nat. Med. (2006) [Pubmed]
  12. Contribution of sensory neurons to sex difference in the development of stress-induced gastric mucosal injury in mice. Shimozawa, N., Okajima, K., Harada, N., Arai, M., Ishida, Y., Shimada, S., Kurihara, H., Nakagata, N. Gastroenterology (2006) [Pubmed]
  13. Pharmacological and molecular characterization of the mechanisms involved in prostaglandin E2-induced mouse paw edema. Claudino, R.F., Kassuya, C.A., Ferreira, J., Calixto, J.B. J. Pharmacol. Exp. Ther. (2006) [Pubmed]
  14. Effects of phorbol esters and pertussis toxin on calcitonin-stimulated accumulation of cyclic AMP in neonatal mouse calvarial bones. Ransjö, M., Lerner, U.H. Calcif. Tissue Int. (1991) [Pubmed]
  15. Decreased bone formation and osteopenia in mice lacking alpha-calcitonin gene-related peptide. Schinke, T., Liese, S., Priemel, M., Haberland, M., Schilling, A.F., Catala-Lehnen, P., Blicharski, D., Rueger, J.M., Gagel, R.F., Emeson, R.B., Amling, M. J. Bone Miner. Res. (2004) [Pubmed]
  16. Increased blood pressure in alpha-calcitonin gene-related peptide/calcitonin gene knockout mice. Gangula, P.R., Zhao, H., Supowit, S.C., Wimalawansa, S.J., Dipette, D.J., Westlund, K.N., Gagel, R.F., Yallampalli, C. Hypertension (2000) [Pubmed]
  17. Characterization of amylin and calcitonin receptor binding in the mouse alpha-thyroid-stimulating hormone thyrotroph cell line. Perry, K.J., Quiza, M., Myers, D.E., Morfis, M., Christopoulos, G., Sexton, P.M. Endocrinology (1997) [Pubmed]
  18. Amylin inhibits bone resorption while the calcitonin receptor controls bone formation in vivo. Dacquin, R., Davey, R.A., Laplace, C., Levasseur, R., Morris, H.A., Goldring, S.R., Gebre-Medhin, S., Galson, D.L., Zajac, J.D., Karsenty, G. J. Cell Biol. (2004) [Pubmed]
  19. Selective loss of calcitonin gene-related Peptide-expressing primary sensory neurons of the a-cell phenotype in early experimental diabetes. Jiang, Y., Nyengaard, J.R., Zhang, J.S., Jakobsen, J. Diabetes (2004) [Pubmed]
  20. Stimulation of interleukin-6 production by either calcitonin gene-related peptide or parathyroid hormone in two phenotypically distinct bone marrow-derived murine stromal cell lines. Sakagami, Y., Girasole, G., Yu, X.P., Boswell, H.S., Manolagas, S.C. J. Bone Miner. Res. (1993) [Pubmed]
  21. Limb proprioceptive deficits without neuronal loss in transgenic mice overexpressing neurotrophin-3 in the developing nervous system. Ringstedt, T., Kucera, J., Lendahl, U., Ernfors, P., Ibáñez, C.F. Development (1997) [Pubmed]
  22. Substance P, calcitonin gene related peptide and PGE2 co-released from the mouse colon: a new model to study nociceptive and inflammatory responses in viscera, in vitro. Roza, C., Reeh, P.W. Pain (2001) [Pubmed]
  23. Inhibitory effect of calcitonin gene-related peptide on myometrial contractility is diminished at parturition. Naghashpour, M., Rosenblatt, M.I., Dickerson, I.M., Dahl, G.P. Endocrinology (1997) [Pubmed]
  24. Binding sites for islet amyloid polypeptide in mammalian lung: species variation and effects on adenylyl cyclase. Bhogal, R., Smith, D.M., Owji, A.A., Bloom, S.R. Can. J. Physiol. Pharmacol. (1995) [Pubmed]
  25. Protein phosphatase inhibitors and bone resorption: inhibition by okadaic acid and biphasic actions of calyculin-A. Goad, D.L., Meurer, E.A., Voelkel, E.F., Petrou, C.P., Tashjian, A.H. Endocrinology (1992) [Pubmed]
  26. Calcitonin-induced changes in the cytoskeleton are mediated by a signal pathway associated with protein kinase A in osteoclasts. Suzuki, H., Nakamura, I., Takahashi, N., Ikuhara, T., Matsuzaki, K., Isogai, Y., Hori, M., Suda, T. Endocrinology (1996) [Pubmed]
  27. Ectopic substance P and calcitonin gene-related peptide immunoreactive fibres in the spinal cord of transgenic mice over-expressing nerve growth factor. Ma, W., Ribeiro-da-Silva, A., Noel, G., Julien, J.P., Cuello, A.C. Eur. J. Neurosci. (1995) [Pubmed]
  28. Calcitonin-dependent down-regulation of the mouse C1a calcitonin receptor in cells of the osteoclast lineage involves a transcriptional mechanism. Inoue, D., Shih, C., Galson, D.L., Goldring, S.R., Horne, W.C., Baron, R. Endocrinology (1999) [Pubmed]
  29. Modulating effects of sensory and autonomic neuropeptides on murine splenocyte proliferation and cytokine secretion induced by Leishmania major. Ahmed, A.A., Mutt, V., Nordlind, K. Immunopharmacology and immunotoxicology. (1999) [Pubmed]
  30. Calcitonin stimulates calcium transport in distal convoluted tubule cells. Gesek, F.A., Friedman, P.A. Am. J. Physiol. (1993) [Pubmed]
  31. Study of innervation, sensory neuropeptides, and serotonin in murine contact allergic skin. El-Nour, H., Lundeberg, L., Boman, A., Beck, O., Harvima, I.T., Theodorsson, E., Nordlind, K. Immunopharmacology and immunotoxicology. (2005) [Pubmed]
  32. Expression of dopaminergic phenotypes in the mouse olfactory bulb induced by the calcitonin gene-related peptide. Denis-Donini, S. Nature (1989) [Pubmed]
  33. Ablation of calcitonin/calcitonin gene-related peptide-alpha impairs fetal magnesium but not calcium homeostasis. McDonald, K.R., Fudge, N.J., Woodrow, J.P., Friel, J.K., Hoff, A.O., Gagel, R.F., Kovacs, C.S. Am. J. Physiol. Endocrinol. Metab. (2004) [Pubmed]
  34. Overexpression of lunatic fringe does not affect epithelial cell differentiation in the developing mouse lung. van Tuyl, M., Groenman, F., Kuliszewski, M., Ridsdale, R., Wang, J., Tibboel, D., Post, M. Am. J. Physiol. Lung Cell Mol. Physiol. (2005) [Pubmed]
  35. Variable sensitivity to noxious heat is mediated by differential expression of the CGRP gene. Mogil, J.S., Miermeister, F., Seifert, F., Strasburg, K., Zimmermann, K., Reinold, H., Austin, J.S., Bernardini, N., Chesler, E.J., Hofmann, H.A., Hordo, C., Messlinger, K., Nemmani, K.V., Rankin, A.L., Ritchie, J., Siegling, A., Smith, S.B., Sotocinal, S., Vater, A., Lehto, S.G., Klussmann, S., Quirion, R., Michaelis, M., Devor, M., Reeh, P.W. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  36. Hair-cycle-associated remodeling of the peptidergic innervation of murine skin, and hair growth modulation by neuropeptides. Peters, E.M., Botchkarev, V.A., Botchkareva, N.V., Tobin, D.J., Paus, R. J. Invest. Dermatol. (2001) [Pubmed]
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