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Gene Review:

SCO0492 - peptide synthetase

Streptomyces coelicolor A3(2)

Watanabe, K. et al., Chong, P.P. et al., Challis, G.L. et al.

Challis, Ravel,

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Disease relevance of SCO0492

The parent strain, BAP1, contains the sfp phosphopantetheinyl transferase gene from Bacillus subtilis, which posttranslationally modifies polyketide synthase and nonribosomal peptide synthetase modules [1].
Putative peptide-synthetase-encoding DNA fragments were isolated from the Streptomyces coelicolor A3(2) chromosome using a PCR-based approach and mapped to a single approximately 35 kb segment [2].

High impact information on SCO0492

Their biosynthetic pathways are especially complex because they involve the formation of 3-amino-5-hydroxybenzoic acid (AHBA) followed by backbone assembly by a hybrid nonribosomal peptide synthetase/polyketide synthase [1].
Coelichelin, a new peptide siderophore encoded by the Streptomyces coelicolor genome: structure prediction from the sequence of its non-ribosomal peptide synthetase [3].

References

Engineered biosynthesis of an ansamycin polyketide precursor in Escherichia coli. Watanabe, K., Rude, M.A., Walsh, C.T., Khosla, C. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
Physical identification of a chromosomal locus encoding biosynthetic genes for the lipopeptide calcium-dependent antibiotic (CDA) of Streptomyces coelicolor A3(2). Chong, P.P., Podmore, S.M., Kieser, H.M., Redenbach, M., Turgay, K., Marahiel, M., Hopwood, D.A., Smith, C.P. Microbiology (Reading, Engl.) (1998) [Pubmed]
Coelichelin, a new peptide siderophore encoded by the Streptomyces coelicolor genome: structure prediction from the sequence of its non-ribosomal peptide synthetase. Challis, G.L., Ravel, J. FEMS Microbiol. Lett. (2000) [Pubmed]

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