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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

MLLT11  -  myeloid/lymphoid or mixed-lineage leukemia...

Homo sapiens

Synonyms: AF1Q, Protein AF1q
 
 
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Disease relevance of MLLT11

 

High impact information on MLLT11

  • Candidate oncogenes bordering this interval (BCL9 and AF1Q) were not rearranged in any patient except one (AF1Q) [2].
  • These data provide functional evidence that oncogene AF1Q may be a novel mediator of metastasis promotion in human breast cancer through regulation of the MMP pathway and RhoC expression [1].
  • Of 60 differentially expressed genes, ALL1-fused gene from chromosome 1q (AF1Q), a putative oncogene not described previously in breast cancer, was identified and found to be over-expressed in MDA-MB-435HM cells compared with MDA-MB-435LM cells [1].
  • To test this hypothesis, we generated an AF1Q high-expression cell line by stable transfection of AF1Q cDNA into MDA-MB-435LM cells [1].

References

  1. Gene expression profile analysis of an isogenic tumour metastasis model reveals a functional role for oncogene AF1Q in breast cancer metastasis. Li, D.Q., Hou, Y.F., Wu, J., Chen, Y., Lu, J.S., Di, G.H., Ou, Z.L., Shen, Z.Z., Ding, J., Shao, Z.M. Eur. J. Cancer (2006) [Pubmed]
  2. Novel evidence of a role for chromosome 1 pericentric heterochromatin in the pathogenesis of B-cell lymphoma and multiple myeloma. Le Baccon, P., Leroux, D., Dascalescu, C., Duley, S., Marais, D., Esmenjaud, E., Sotto, J.J., Callanan, M. Genes Chromosomes Cancer (2001) [Pubmed]
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