The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

BCL9  -  B-cell CLL/lymphoma 9

Homo sapiens

Synonyms: B-cell CLL/lymphoma 9 protein, B-cell lymphoma 9 protein, Bcl-9, Protein legless homolog
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of BCL9


High impact information on BCL9

  • Stimulation of the Wnt pathway leads to the association of beta-catenin with Tcf and BCL9 in the nucleus, resulting in the transactivation of Wnt target genes [4].
  • Crystal Structure of a beta-Catenin/BCL9/Tcf4 Complex [4].
  • Low-level expression of BCL9 was detected in Epstein-Barr virus-transformed normal B cells by Northern blot; in contrast, abundant BCL9 expression was observed in CEMO-1, indicating that deregulated expression of this gene was one pathological consequence of the translocation [5].
  • Molecular cloning of translocation t(1;14)(q21;q32) defines a novel gene (BCL9) at chromosome 1q21 [5].
  • Full-length BCL9 cDNA clones were obtained from a normal human fetal brain cDNA library supplemented by 5' and 3' RACE [5].

Biological context of BCL9

  • Candidate oncogenes bordering this interval (BCL9 and AF1Q) were not rearranged in any patient except one (AF1Q) [6].

Anatomical context of BCL9

  • These data suggest that BCL9 may be the target of translocation in some B-cell malignancies with abnormalities of 1q21 and that deregulated BCL9 expression may be important in their pathogenesis [5].
  • In addition, the BCL9 gene was not over-expressed in SKI-DLCL-1 cell line [2].

Other interactions of BCL9


Analytical, diagnostic and therapeutic context of BCL9

  • Screening of a panel of 39 B-cell malignancies with 1q abnormalities by Southern blot showed one additional case with a breakpoint in the 3' UTR of BCL9, indicating that this was a recurrent breakpoint [5].


  1. Fusion of the BCL9 HD2 domain to E1A increases the cytopathic effect of an oncolytic adenovirus that targets colon cancer cells. Fuerer, C., Homicsko, K., Lukashev, A.N., Pittet, A.L., Iggo, R.D. BMC Cancer (2006) [Pubmed]
  2. Establishment of a human cell line (SKI-DLCL-1) with a t(1;14)(q21;q32) translocation from the ascites of a patient with diffuse large cell lymphoma. Goy, A., Gilles, F., Remache, Y., Filippa, D., Portlock, C.S., Jhanwar, S.C., Zelenetz, A.D. Leuk. Lymphoma (2001) [Pubmed]
  3. B-cell lymphoma developing in the donor 9 years after donor-origin acute myeloid leukemia post bone marrow transplantation. Bielorai, B., Deeg, H.J., Weintraub, M., Neumann, Y., Rosner, E., Amariglio, N., Rechavi, G., Toren, A. Bone Marrow Transplant. (2003) [Pubmed]
  4. Crystal Structure of a beta-Catenin/BCL9/Tcf4 Complex. Sampietro, J., Dahlberg, C.L., Cho, U.S., Hinds, T.R., Kimelman, D., Xu, W. Mol. Cell (2006) [Pubmed]
  5. Molecular cloning of translocation t(1;14)(q21;q32) defines a novel gene (BCL9) at chromosome 1q21. Willis, T.G., Zalcberg, I.R., Coignet, L.J., Wlodarska, I., Stul, M., Jadayel, D.M., Bastard, C., Treleaven, J.G., Catovsky, D., Silva, M.L., Dyer, M.J. Blood (1998) [Pubmed]
  6. Novel evidence of a role for chromosome 1 pericentric heterochromatin in the pathogenesis of B-cell lymphoma and multiple myeloma. Le Baccon, P., Leroux, D., Dascalescu, C., Duley, S., Marais, D., Esmenjaud, E., Sotto, J.J., Callanan, M. Genes Chromosomes Cancer (2001) [Pubmed]
  7. Genomic instability in multiple myeloma: evidence for jumping segmental duplications of chromosome arm 1q. Sawyer, J.R., Tricot, G., Lukacs, J.L., Binz, R.L., Tian, E., Barlogie, B., Shaughnessy, J. Genes Chromosomes Cancer (2005) [Pubmed]
WikiGenes - Universities