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Gene Review:

Acy1 - aminoacylase 1

Mus musculus

Synonyms: 1110014J22Rik, ACY-1, Acy-1, Aminoacylase-1, N-acyl-L-amino-acid amidohydrolase

Maceyka, M. et al., Nadeau, J.H., Naylor, S.L. et al.

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High impact information on Acy1

Aminoacylase 1 is a sphingosine kinase 1-interacting protein [1].
Though both C-terminal and full-length proteins slightly reduce SphK1 activity measured in vitro, the C-terminal fragment inhibits while full-length Acy1 potentiates the effects of SphK1 on proliferation and apoptosis [1].
One of these was identified as aminoacylase 1 (Acy1), a metalloenzyme that removes amide-linked acyl groups from amino acids and may play a role in regulating responses to oxidative stress [1].
A chromosomal segment conserved since divergence of lineages leading to man and mouse: the gene order of aminoacylase-1, transferrin, and beta-galactosidase on mouse chromosome 9 [2].
Bioautographic visualization of aminoacylase-1: assignment of the structural gene ACY-1 to chromosome 3 in man [3].

Analytical, diagnostic and therapeutic context of Acy1

Interestingly, Acy1 induces redistribution of SphK1 as observed by immunocytochemistry and subcellular fractionation [1].

References

Aminoacylase 1 is a sphingosine kinase 1-interacting protein. Maceyka, M., Nava, V.E., Milstien, S., Spiegel, S. FEBS Lett. (2004) [Pubmed]
A chromosomal segment conserved since divergence of lineages leading to man and mouse: the gene order of aminoacylase-1, transferrin, and beta-galactosidase on mouse chromosome 9. Nadeau, J.H. Genet. Res. (1986) [Pubmed]
Bioautographic visualization of aminoacylase-1: assignment of the structural gene ACY-1 to chromosome 3 in man. Naylor, S.L., Shows, T.B., Klebe, R.J. Somatic Cell Genet. (1979) [Pubmed]

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AgaP_AGAP000679	Anopheles gambiae str. PEST
AT4G38220	Arabidopsis thaliana
ACY1	Bos taurus
C10C5.5	Caenorhabditis elegans
C10C5.4	Caenorhabditis elegans
C06A6.4	Caenorhabditis elegans
C10C5.3	Caenorhabditis elegans
ACY1	Canis lupus familiaris
acy1	Danio rerio
LOC100001620	Danio rerio
CG17110	Drosophila melanogaster
CG6733	Drosophila melanogaster
CG17109	Drosophila melanogaster
CG6738	Drosophila melanogaster
CG6465	Drosophila melanogaster
CG6726	Drosophila melanogaster
ACY1	Gallus gallus
ACY1	Homo sapiens
ACY1	Pan troglodytes
Acy1	Rattus norvegicus
acy1.1	Xenopus (Silurana) tropicalis

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