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Gene Review:

Pygl - liver glycogen phosphorylase

Mus musculus

Synonyms: Glycogen phosphorylase, liver form

Storey, K.B., Roesler, W.J. et al., Billingsley, G.D. et al., Waagepetersen, H.S. et al., Roesler, W.J. et al., et al.

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Disease relevance of Pygl

1. The enzyme deficient in glycogen storage disease type VI, liver glycogen phosphorylase (PYGL), has been localized by in situ hybridization to 14q21-->q22, near the q21-->q22 band interface [1].

High impact information on Pygl

Liver glycogen phosphorylase activity was strongly depressed during both short (less than 24 h) and long (5-8 days) term hibernation, the mechanism involving a decrease in both the percentage of enzyme in the active a form and the total amount (a + b) of enzyme expressed [2].
A novel inhibitor of liver glycogen phosphorylase, isofagomine, was investigated as a possible inhibitor of the enzyme in the brain and in cultured astrocytes [3].
The diurnal rhythm of liver glycogen phosphorylase: correlating changes in enzyme activity and enzymic protein [4].
We have recently demonstrated that the activity of liver glycogen phosphorylase, the rate-limiting enzyme of glycogenolysis, is elevated in genetically diabetic (db/db) mouse and that it is primarily due to the presence of increased amounts of this enzyme [5].
Effect of patulin on mouse liver glycogen phosphorylase [6].

References

Regional localization of loci on chromosome 14 using somatic cell hybrids. Billingsley, G.D., Cox, D.W., Duncan, A.M., Goodfellow, P.J., Grzeschik, K.H. Cytogenet. Cell Genet. (1994) [Pubmed]
Regulation of liver metabolism by enzyme phosphorylation during mammalian hibernation. Storey, K.B. J. Biol. Chem. (1987) [Pubmed]
The effects of isofagomine, a potent glycogen phosphorylase inhibitor, on glycogen metabolism in cultured mouse cortical astrocytes. Waagepetersen, H.S., Westergaard, N., Schousboe, A. Neurochem. Int. (2000) [Pubmed]
The diurnal rhythm of liver glycogen phosphorylase: correlating changes in enzyme activity and enzymic protein. Roesler, W.J., Khandelwal, R.L. FEBS Lett. (1986) [Pubmed]
The rate of degradation of liver glycogen phosphorylase is specifically decreased in the C57BL/KsJ-db/db mouse. Roesler, W.J., Nijjar, M.S., Khandelwal, R.L. Mol. Cell. Biochem. (1989) [Pubmed]
Effect of patulin on mouse liver glycogen phosphorylase. Madiyalakan, R., Shanmugasundaram, E.R. Indian J. Exp. Biol. (1978) [Pubmed]

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AT3G29320	Arabidopsis thaliana
AGOS_AFR547W	Ashbya gossypii ATCC 10895
PYGL	Bos taurus
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PYGL	Gallus gallus
PYGL	Homo sapiens
KLLA0F10065g	Kluyveromyces lactis NRRL Y-1140
PYGL	Macaca mulatta
MGG_01819	Magnaporthe oryzae 70-15
NCU07027	Neurospora crassa OR74A
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Pygl	Rattus norvegicus
GPH1	Saccharomyces cerevisiae S288c
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