High impact information on Pygl

• Rat liver glycogen phosphorylase was inhibited by 2,5-anhydro-D-mannitol 1-phosphate (apparent Ki = 0.66 +/- 0.09 mM) but was little affected by 2,5-anhydro-D-mannitol 1,6-bisphosphate [1].
• The effects of adrenalectomy on glucagon activation of liver glycogen phosphorylase and glycogenolysis were studied in isolated hepatocytes [2].
• Effects of chronic ethanol ingestion on liver glycogen phosphorylase in male and female rats [3].
• Vasopressin and alpha-adrenergic agonists are known to be potent cyclic AMP-independent Ca2+-dependent activators of liver glycogen phosphorylase [4].
• However, the peptide caused a fall in liver glycogen (52 +/- 6.5 to 41 +/- 3.3 mg/g) and a 7-fold increase in the activity of the 5'-AMP independent form of liver glycogen phosphorylase [5].

Biological context of Pygl

• The gene encoding rat liver glycogen phosphorylase contains multiple polyadenylation signal sequences [6].
• Characterization of the 5' flanking region of the gene encoding rat liver glycogen phosphorylase [7].
• The nucleotide sequence of rat liver glycogen phosphorylase cDNA [8].
• Human and rat liver glycogen phosphorylase showed 86% homology at the DNA level whereas the deduced amino acid sequence has 93.5% identity [8].
• It was found that at 21.5 days of gestation, GH increases the fetal liver glucose-6-phosphatase activity and decreases the liver glycogen phosphorylase activity [9].

Anatomical context of Pygl

• Adrenoceptor-mediated activation of liver glycogen phosphorylase: effects of thyroid state [10].

Associations of Pygl with chemical compounds

• The activation of liver glycogen phosphorylase by angiotensin II [11].
• The activation of liver glycogen phosphorylase by vasopressin [12].
• Route of administration of pentobarbital affects activity of liver glycogen phosphorylase [13].
• The stimulation of liver phosphorylase b by AMP, fluoride and sulfate. A technical note on the specific determination of the a and b forms of liver glycogen phosphorylase [14].
• Fasting reduces the response of liver glycogen phosphorylase to physiological levels of epinephrine in rats [15].

Other interactions of Pygl

• Inhibitory effect of fasting on the activation of liver glycogen phosphorylase of rats by arginine-vasopressin [16].

References