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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

VAX1  -  ventral anterior homeobox 1

Homo sapiens

Synonyms: Ventral anterior homeobox 1
 
 
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High impact information on VAX1

  • Abrogation of Vax1 and Vax2 activity leads to a failure to close the choroid fissure and progressive expansion of retinal tissue into the optic nerve, finally resulting in a fusion of retinal neurons and pigment epithelium with forebrain tissue [1].
  • Finally, we show that Pax2.1 and Vax1/Vax2 are likely to act in parallel downstream of Hh activity and that the bel locus (yet to be cloned) mediates the ability of Hh-, and perhaps Fgf-, signals to induce Vax expression in the preoptic area [1].

References

  1. Hedgehog signalling maintains the optic stalk-retinal interface through the regulation of Vax gene activity. Take-uchi, M., Clarke, J.D., Wilson, S.W. Development (2003) [Pubmed]
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