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Gene Review

Mlvi4  -  Moloney-MuLV integration site 4

Mus musculus

Synonyms: Mlvi-4
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Disease relevance of Mlvi4


High impact information on Mlvi4

  • Evidence presented elsewhere shows that provirus integration in Mlvi-4 enhances the expression of c-myc and Mlvi-1 by cis-acting mechanisms operating over long distances of genomic DNA [2].
  • This suggests that Mlvi-4 may be expressed only in a subpopulation of T cells [2].
  • The Mlvi-4 gene is also expressed in normal thymus and spleen at very low levels, giving rise to 3- and 5.5-kilobase messages [2].

Other interactions of Mlvi4

  • In this manuscript, we show that provirus integration in the Mlvi-4 locus activates, by promoter insertion, one additional gene which maps immediately 3' to the cluster of the Mlvi-4 proviruses and which is transcribed in the same orientation as c-myc, giving rise to 3- and 10-kilobase mRNA transcripts [2].
  • Although Mlvi-4 is expressed in normal thymus, it is not expressed in Moloney murine leukemia virus-induced T-cell lymphomas corresponding to several stages of T-cell differentiation, but lacking a provirus in this locus [2].


  1. Activation of the Mlvi-1/mis1/pvt-1 locus in Moloney murine leukemia virus-induced T-cell lymphomas. Tsichlis, P.N., Shepherd, B.M., Bear, S.E. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  2. Activation of multiple genes by provirus integration in the Mlvi-4 locus in T-cell lymphomas induced by Moloney murine leukemia virus. Tsichlis, P.N., Lee, J.S., Bear, S.E., Lazo, P.A., Patriotis, C., Gustafson, E., Shinton, S., Jenkins, N.A., Copeland, N.G., Huebner, K. J. Virol. (1990) [Pubmed]
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