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Gene Review

Pvt1  -  plasmacytoma variant translocation 1

Mus musculus

Synonyms: Ayu21-84Imeg, Gt(Ayu21)84Imeg, Gt(pU21)84Imeg, Mis-1, Mlvi-1, ...
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Disease relevance of Pvt1


High impact information on Pvt1


Biological context of Pvt1

  • This defect may be responsible for the inability of normal BALB/cAnPt lymphoblasts to repair DNA sequences in the c-myc 5' flank and the Pvt1 gene, inducing gene-specific instability that predisposes these loci to genetic accidents, including chromosomal translocation, retroviral integration and other mutations [8].
  • This finding indicates that, in BALB/cAnPt lymphoblasts, DNA repair 5' to c-myc and in Pvt1 is decoupled from the RNA transcription machinery [8].
  • In this study, we identified the chromosomal map location of the Mlvi -2 homologous sequences in mice by using hamster-mouse somatic cell hybrids [3].
  • Over the past several years, our laboratory has been instrumental in the elucidation of the structure of the mouse Pvt 1 locus as a means of understanding the relationship between these two divergent Txs which, nevertheless, produce indistinguishable disease phenotypes [5].
  • The alpha-globin pseudogene, Hba-3ps, was mapped in close proximity to Mlvi-1 in 15D2 [9].

Anatomical context of Pvt1

  • We have recently constructed transgenic mice harboring a translocated Pvt 1/Ck segment in order to determine whether 1). these mice produce the Pvt 1/Ck fusion product 2). these mice are immunocompromised and 3). these mice develop tumors of a B cell origin [5].
  • The Mlvi-1 locus involved in the induction of rat T-cell lymphomas and the pvt-1/Mis-1 locus are identical [10].

Regulatory relationships of Pvt1


Other interactions of Pvt1


Analytical, diagnostic and therapeutic context of Pvt1


  1. Pvt-1 transcripts are found in normal tissues and are altered by reciprocal(6;15) translocations in mouse plasmacytomas. Huppi, K., Siwarski, D., Skurla, R., Klinman, D., Mushinski, J.F. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  2. Genetic mapping of a cellular DNA region involved in induction of thymic lymphomas (Mlvi-1) to mouse chromosome 15. Kozak, C.A., Strauss, P.G., Tsichlis, P.N. Mol. Cell. Biol. (1985) [Pubmed]
  3. Cellular DNA region involved in induction of thymic lymphomas (Mlvi-2) maps to mouse chromosome 15. Tsichlis, P.N., Strauss, P.G., Kozak, C.A. Mol. Cell. Biol. (1984) [Pubmed]
  4. Activation of multiple genes by provirus integration in the Mlvi-4 locus in T-cell lymphomas induced by Moloney murine leukemia virus. Tsichlis, P.N., Lee, J.S., Bear, S.E., Lazo, P.A., Patriotis, C., Gustafson, E., Shinton, S., Jenkins, N.A., Copeland, N.G., Huebner, K. J. Virol. (1990) [Pubmed]
  5. Structure and expression of the c-Myc/Pvt 1 megagene locus. Siwarski, D., Müller, U., Andersson, J., Notario, V., Melchers, F., Rolink, A., Huppi, K. Curr. Top. Microbiol. Immunol. (1997) [Pubmed]
  6. Activation of the Mlvi-1/mis1/pvt-1 locus in Moloney murine leukemia virus-induced T-cell lymphomas. Tsichlis, P.N., Shepherd, B.M., Bear, S.E. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  7. Proviral integration site Mis-1 in rat thymomas corresponds to the pvt-1 translocation breakpoint in murine plasmacytomas. Villeneuve, L., Rassart, E., Jolicoeur, P., Graham, M., Adams, J.M. Mol. Cell. Biol. (1986) [Pubmed]
  8. Decoupling of DNA excision repair and RNA transcription in translocation breaksite regions of plasmacytoma-susceptible BALB/cAnPt mice. Beecham, E.J., Owens, J.D., Shaughnessy, J.D., Huppi, K., Bohr, V.A., Mushinski, J.F. Carcinogenesis (1997) [Pubmed]
  9. Localization of proviral integration sites (Mlvi-1, Mlvi-2, and Pvt-1) and the alpha-globin pseudogene, Hba-3ps, on murine chromosome 15. Adolph, S., Strauss, P.G., Hameister, H. Cytogenet. Cell Genet. (1988) [Pubmed]
  10. The Mlvi-1 locus involved in the induction of rat T-cell lymphomas and the pvt-1/Mis-1 locus are identical. Koehne, C.F., Lazo, P.A., Alves, K., Lee, J.S., Tsichlis, P.N., O'Donnell, P.V. J. Virol. (1989) [Pubmed]
  11. A novel c-myc-activating reciprocal T(12;15) chromosomal translocation juxtaposes S alpha to Pvt-1 in a mouse plasmacytoma. Shaughnessy, J., Wiener, F., Huppi, K., Mushinski, J.F., Potter, M. Oncogene (1994) [Pubmed]
  12. cDNA sequence and chromosomal localization of the mouse parvalbumin gene, Pva. Zühlke, C., Schöffl, F., Jockusch, H., Simon, D., Guénet, J.L. Genet. Res. (1989) [Pubmed]
  13. Cellular DNA regions involved in the induction of rat thymic lymphomas (Mlvi-1, Mlvi-2, Mlvi-3, and c-myc) represent independent loci as determined by their chromosomal map location in the rat. Tsichlis, P.N., Lohse, M.A., Szpirer, C., Szpirer, J., Levan, G. J. Virol. (1985) [Pubmed]
  14. c-myc gene in a murine plasmocytoma without visible chromosomal translocations moves to chromosome 12F1 with Pvt-1 and rearranges with IgH enhancer-S mu sequences. Ohno, S., Migita, S., Murakami, S. Int. J. Cancer (1991) [Pubmed]
  15. Amplified extrachromosomal elements containing c-Myc and Pvt 1 in a mouse plasmacytoma. Mai, S., Hanley-Hyde, J., Coleman, A., Siwarski, D., Huppi, K. Genome (1995) [Pubmed]
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