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Gene Review

Ldr1  -  lactate dehydrogenase regulator 1

Mus musculus

Synonyms: Ldr-1
 
 
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High impact information on Ldr1

  • Five of twelve B6.SW-Soaa strains were found to retain Ldr-1, lactate dehydrogenase regulator-1, on chromosome 6 as an allelic passenger from the SWR/J donor strain (source of the Soaa Taster allele) [1].
  • Linkage tests indicated that the locus Ldr-2 determining the amounts of the LDH B subunit in mouse liver tissue is located in chromosome 6, 19 + or - 4.1 cm away from the earlier described Ldr-1 locus [2].
  • Inadequate genotyping may have occurred at Gpi-1 and Ldr-1, as suggested by a 'week effect' on the observed genotype numbers (P less than 0.05) [3].
  • It is of interest then that there is a mouse gene, Ldr-1, on chromosome 6 that regulates the level of LDH B subunits in mouse erythrocytes [4].

References

  1. Chromosome mapping of Soa, a gene influencing gustatory sensitivity to sucrose octaacetate in mice. Capeless, C.G., Whitney, G., Azen, E.A. Behav. Genet. (1992) [Pubmed]
  2. A new locus regulating the expression of the Ldh-2 gene in mouse liver. Khlebodarova, T.M., Serov, O.L. Biochem. Genet. (1980) [Pubmed]
  3. Genic heterogeneity and genetic monitoring of mouse outbred stocks. Groen, A., Lagerwerf, A.J. Lab. Anim. (1979) [Pubmed]
  4. Assignment of a Mus musculus gene for triosephosphate isomerase to chromosome 6 and for glyoxalase-I to chromosome 17 using somatic cell hybrids. Minna, J.D., Bruns, G.A., Krinsky, A.H., Lalley, P.A., Francke, U., Gerald, P.S. Somatic Cell Genet. (1978) [Pubmed]
 
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