Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

Ldr1 - lactate dehydrogenase regulator 1

Mus musculus

Synonyms: Ldr-1

Groen, A. et al., Khlebodarova, T.M. et al., Capeless, C.G. et al., Minna, J.D. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on Ldr1

Five of twelve B6.SW-Soaa strains were found to retain Ldr-1, lactate dehydrogenase regulator-1, on chromosome 6 as an allelic passenger from the SWR/J donor strain (source of the Soaa Taster allele) [1].
Linkage tests indicated that the locus Ldr-2 determining the amounts of the LDH B subunit in mouse liver tissue is located in chromosome 6, 19 + or - 4.1 cm away from the earlier described Ldr-1 locus [2].
Inadequate genotyping may have occurred at Gpi-1 and Ldr-1, as suggested by a 'week effect' on the observed genotype numbers (P less than 0.05) [3].
It is of interest then that there is a mouse gene, Ldr-1, on chromosome 6 that regulates the level of LDH B subunits in mouse erythrocytes [4].

References

Chromosome mapping of Soa, a gene influencing gustatory sensitivity to sucrose octaacetate in mice. Capeless, C.G., Whitney, G., Azen, E.A. Behav. Genet. (1992) [Pubmed]
A new locus regulating the expression of the Ldh-2 gene in mouse liver. Khlebodarova, T.M., Serov, O.L. Biochem. Genet. (1980) [Pubmed]
Genic heterogeneity and genetic monitoring of mouse outbred stocks. Groen, A., Lagerwerf, A.J. Lab. Anim. (1979) [Pubmed]
Assignment of a Mus musculus gene for triosephosphate isomerase to chromosome 6 and for glyoxalase-I to chromosome 17 using somatic cell hybrids. Minna, J.D., Bruns, G.A., Krinsky, A.H., Lalley, P.A., Francke, U., Gerald, P.S. Somatic Cell Genet. (1978) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

Editor

Share