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Gene Review

Ldhb  -  lactate dehydrogenase B

Mus musculus

Synonyms: AI790582, H-Ldh, L-lactate dehydrogenase B chain, LDH heart subunit, LDH-B, ...
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Disease relevance of Ldhb

  • These observations raise the possibility that the heterogeneity in glucose metabolism and, in particular, the sole expression of LDH-B, might identify an important biological marker of glioma cells that is critical for their progression and that might afford a new target for anticancer drugs [1].
  • Hybridomas secreting a monoclonal T suppressor-effector factor (TseF) were produced by fusion of a lactate dehydrogenase B (LDHB)-specific long-term T suppressor-effector (Tse) cell line with the BW5147 thymoma [2].
  • In the heterozygous T lymphoma line LDHB, variants which have lost the expression of individual H-2 class I genes are spontaneously generated in vitro at a frequency of 10(-1)-10(-2) [3].

High impact information on Ldhb

  • We characterized the cell types involved in the H-2-controlled suppression of T cell response to lactate dehydrogenase B (LDHB) [4].
  • A cell line (HK13) in which the class I gene Kk is stably expressed (frequency of loss variants less than 10(-4) was selected from LDHB cells by fluorescence activated cell sorting [3].
  • The instability of class I gene expression in LDHB cells and the transition to stable expression may represent steps of T-cell differentiation in the thymus [3].
  • The hybridoma produced by the fusion of lactate dehydrogenase-B (LDH-B)-primed B10.A(2R) mouse suppressor T (Ts) cells with the BW5147 thymoma secretes two kinds of T suppressor factors (TsF), TsF-A and TsF-E [5].
  • These data suggest that, in some H-2 haplotypes, the response to LDH-B and IgG2a is the result of interaction between the I-A and I-E subregions [6].

Biological context of Ldhb


Anatomical context of Ldhb

  • The lactate dehydrogenase-B cDNA insert of thymus clone mB188 consists of the protein-coding sequence (1002 nucleotides), the 5' (46 nucleotides) and 3' (190 nucleotides) non-coding regions, and poly(A) tail (19 nucleotides), while macrophage clone mB168 contains a partial lactate dehydrogenase cDNA insert from codon no [7].
  • This is in contrast to a previous report that the LDH-B subunit was not synthesized in germ cells [10].
  • Sertoli cells were further shown to exhibit comparable amounts of five tetrameric LDH isozymes formed by combination of muscle-type LDH-A and heart-type LDH-B subunits [10].
  • By using an improved Cellogel electrophoretic procedure the isozyme patterns observed in the erythrocytes and leukocytes of the variant have indicated that the CAL1 is not variant of LDHA but that of LDHB, a chromosome 12 marker [11].
  • In a study of 35 horse-mouse heterohybridoma cell lines, synteny in the horse was found between LDHB, PEPB and IGF1 and between NP, MPI and IDH2 [12].

Associations of Ldhb with chemical compounds

  • The predicted sequence of 333 amino acids, excluding initiation methionine, was confirmed by sequencing and/or compositional analyses of a total of 103 (31%) amino acids from tryptic peptides of mouse lactate dehydrogenase-B protein [7].
  • Separation of the Ia determinants used in restricting these two antigen responses was further confirmed when pretreatment of B10.S(9R) (A alpha sA beta sE beta sJk) macrophages with A.TL anti-B10.HTT (anti-A beta sE beta sJs) serum absorbed with B10.BASR1 spleen cells blocked the LDH-B response but not the MOPC-173 response [13].
  • These patterns of response to urethane matched the patterns of the immune response to lactate dehydrogenase-B (LDH-B) and immunoglobulin gamma 2a (IgG2a) proteins [14].

Other interactions of Ldhb

  • Two of these, ldha and ldhb, are expressed ubiquitously [15].
  • Linkage tests indicated that the locus Ldr-2 determining the amounts of the LDH B subunit in mouse liver tissue is located in chromosome 6, 19 + or - 4.1 cm away from the earlier described Ldr-1 locus [16].
  • Lastly, by using the A beta mutant strain, B6CH-2bm12, it was shown that the Ir gene and Ia determinants affected by this mutation had no effect on the LDH-B and MOPC-173 proliferative responses [13].
  • The major histocompatibility complex-controlled immune responsiveness of mice to two unrelated antigens, lactate dehydrogenase B (LDHB) and IgG2a myeloma protein is remarkably similar (1, 2) [17].
  • Mouse hybridomas generated by fusion between a lactate dehydrogenase-B (LDH-B)-specific B10.A(2R) T suppressor (Ts) cell line and the BW5147 thymoma secrete two suppressor factors, TsF-A and TsF-E [18].


  1. Glucose metabolism heterogeneity in human and mouse malignant glioma cell lines. Griguer, C.E., Oliva, C.R., Gillespie, G.Y. J. Neurooncol. (2005) [Pubmed]
  2. Monoclonal suppressor factor specific for lactate dehydrogenase B. I. Mechanism of interaction between the factor and its target cells. Ikezawa, Z., Baxevanis, C.N., Nonaka, M., Abe, R., Tada, T., Nagy, Z.A., Klein, J. J. Exp. Med. (1983) [Pubmed]
  3. Somatic variation of H-2Kk expression and structure in a T-cell lymphoma: instability, stabilization, high production and structural mutation. Holtkamp, B., Cramer, M., Rajewsky, K. EMBO J. (1983) [Pubmed]
  4. H-2-controlled suppression of T cell response to lactate dehydrogenase B. Characterization of the lactate dehydrogenase B suppressor pathway. Baxevanis, C.N., Ishii, N., Nagy, Z.A., Klein, J. J. Exp. Med. (1982) [Pubmed]
  5. Evidence for two suppressor factors secreted by a single cell suggests a solution to the J-locus paradox. Ikezawa, Z., Baxevanis, C.N., Arden, B., Tada, T., Waltenbaugh, C.R., Nagy, Z.A., Klein, J. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
  6. A novel type of T-T cell interaction removes the requirement for I-B region in the H-2 complex. Baxevanis, C.N., Nagy, Z.A., Klein, J. Proc. Natl. Acad. Sci. U.S.A. (1981) [Pubmed]
  7. The cDNA and protein sequences of mouse lactate dehydrogenase B. Molecular evolution of vertebrate lactate dehydrogenase genes A (muscle), B (heart) and C (testis). Hiraoka, B.Y., Sharief, F.S., Yang, Y.W., Li, W.H., Li, S.S. Eur. J. Biochem. (1990) [Pubmed]
  8. Lactate dehydrogenase A-dependent surface expression of immature thymocyte antigen-1: an implication for a novel trafficking function of lactate dehydrogenase-A during T cell development. Fujishiro, Y., Kishi, H., Matsuda, T., Fuse, H., Muraguchi, A. Eur. J. Immunol. (2000) [Pubmed]
  9. Linkage of lactate dehydrogenase-2, Ldh-2, in the mouse. Peters, J., Andrews, S.J. Biochem. Genet. (1985) [Pubmed]
  10. Differential activity and synthesis of lactate dehydrogenase isozymes A (muscle), B (heart), and C (testis) in mouse spermatogenic cells. Li, S.S., O'Brien, D.A., Hou, E.W., Versola, J., Rockett, D.L., Eddy, E.M. Biol. Reprod. (1989) [Pubmed]
  11. Defining the locus of origin of a genetically determined electrophoretic variant of a multilocus enzyme system; the Calcutta-1 of human LDH system is a B-locus variant. Herbschleb-Voogt, E., Meera Khan, P. Hum. Genet. (1981) [Pubmed]
  12. Synteny mapping in the horse using horse-mouse heterohybridomas. Williams, H., Richards, C.M., Konfortov, B.A., Miller, J.R., Tucker, E.M. Anim. Genet. (1993) [Pubmed]
  13. Separation of the immune response genes for LDH-B and MOPC-173. I. Description of an immune response defect in B10.BASR1. Gutmann, D.H., Allen, P.M., Niederhuber, J.E. J. Immunol. (1983) [Pubmed]
  14. The H-2 class II genes and the susceptibility to the development of pulmonary adenoma in mice. Miyashita, N., Moriwaki, K., Migita, S. Immunogenetics (1989) [Pubmed]
  15. Transgenic mice demonstrate a testis-specific promoter for lactate dehydrogenase, LDHC. Li, S., Zhou, W., Doglio, L., Goldberg, E. J. Biol. Chem. (1998) [Pubmed]
  16. A new locus regulating the expression of the Ldh-2 gene in mouse liver. Khlebodarova, T.M., Serov, O.L. Biochem. Genet. (1980) [Pubmed]
  17. Cross-reactivity of suppressor T cells specific for lactate dehydrogenase B and IgG2a myeloma protein. Nagy, Z.A., Baxevanis, C.N., Klein, J. J. Immunol. (1983) [Pubmed]
  18. Feedback regulation of immune suppression by a suppressor factor. Ikezawa, Z., Arden, B., Nagy, Z.A., Klein, J. Eur. J. Immunol. (1984) [Pubmed]
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