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Gene Review

Gpi1  -  glucose phosphate isomerase 1

Mus musculus

Synonyms: AMF, Amf, Autocrine motility factor, GPI, Glucose-6-phosphate isomerase, ...
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Disease relevance of Gpi1


Psychiatry related information on Gpi1


High impact information on Gpi1


Chemical compound and disease context of Gpi1


Biological context of Gpi1

  • We propose that glycolysis in Gpi1-negative cells proceeds entirely through the pentose phosphate pathway, creating NADPH at the cost of organic carbon [1].
  • This distribution explains why the absolute amounts of Gpi1 protein were not appreciably different between wild-type and the rd/rd phenotype, where rods and cones are absent, whilst the relative contribution of Gpi1 to the total protein and RNA pools differed [1].
  • Analysis of diabetes progression in another NOD stock congenic for C57BL/6 alleles on Chromosome 7 linked to the glucose phosphate isomerase (Gpi1(b)) locus provided no protection, indicating that the diabetes resistance (Idd) gene was distal to 34 cM (D7Mit346) [12].
  • A pavillion effect on the observed genotype numbers was found for Pgm-1 and Gpi-1 (P less than 0.10) [13].
  • Removal of GPI-anchored cell surface proteins by phosphatidylinositol-specific phospholipase C treatment rendered cells resistant to NAD-mediated apoptosis [14].

Anatomical context of Gpi1

  • This mouse produced 28 offspring, eight of which were derived from homozygous Gpi1(-/-) null oocytes [15].
  • DNA in situ hybridization also showed that some Gpi1(-/-) follicle cells were able to survive in chimaeric ovarian follicles [15].
  • These results strongly indicate that the GPI-anchor is critical for this pathway of T cell activation [7].
  • Neuroleukin also supports the survival of cultured sensory neurons that are insensitive to nerve growth factor, but has no effect on sympathetic or parasympathetic neurons [4].
  • Neuroleukin promotes the survival in culture of a subpopulation of embryonic spinal neurons that probably includes skeletal motor neurons [4].

Associations of Gpi1 with chemical compounds


Regulatory relationships of Gpi1


Other interactions of Gpi1

  • The GPI-anchored isoform is functionally important, because on a cell on which it was expressed almost as well as the 100 kDa isoform, treatment with PI-PLC reduced VLA-4-dependent conjugate formation [22].
  • On the same genetic background in a backcross segregating for Rb9, the Gpi-1-Ldh-1 recombination percentage was 7.1 +/- 1 [9].
  • A genetic interpretation is proposed to explain the patterns observed for MDH and GPI (with a dimeric structure) and for PGM (monomeric structure); a comparison is made with electrophoretic data available for S. mansoni and S. rodhaini [23].
  • Analysis of progeny from reciprocal backcrosses established that the electrophoretic forms are expressed codominantly and that Pep-4 is located between the genes for glucosephosphate isomerase (Gpi-1) and pink-eyed dilution (p) on chromosome 7 [24].
  • In a backcross using the Robertsonian translocation Rb(7.18)9Lub (Rb9) as the centromeric marker, the centromere-Gpi-1 recombination percentage was 4.5 +/- 1.3, demonstrating that Rb9 suppresses recombination near the centromere of chromosome 7 [9].

Analytical, diagnostic and therapeutic context of Gpi1


  1. Absence of phosphoglucose isomerase-1 in retinal photoreceptor, pigment epithelium and Muller cells. Archer, S.N., Ahuja, P., Caffé, R., Mikol, C., Foster, R.G., van Veen, T., von Schantz, M. Eur. J. Neurosci. (2004) [Pubmed]
  2. Role of poly(ADP-ribose) glycohydrolase in the development of inflammatory bowel disease in mice. Cuzzocrea, S., Mazzon, E., Genovese, T., Crisafulli, C., Min, W.K., Di Paola, R., Mui??, C., Li, J.H., Malleo, G., Xu, W., Massuda, E., Esposito, E., Zhang, J., Wang, Z.Q. Free Radic. Biol. Med. (2007) [Pubmed]
  3. Application of the ovarian teratoma mapping method in the mouse. Eppig, J.T., Eicher, E.M. Genetics (1983) [Pubmed]
  4. Molecular cloning and expression of neuroleukin, a neurotrophic factor for spinal and sensory neurons. Gurney, M.E., Heinrich, S.P., Lee, M.R., Yin, H.S. Science (1986) [Pubmed]
  5. Glycogen synthase: a putative locus for diet-induced hyperglycemia. Seldin, M.F., Mott, D., Bhat, D., Petro, A., Kuhn, C.M., Kingsmore, S.F., Bogardus, C., Opara, E., Feinglos, M.N., Surwit, R.S. J. Clin. Invest. (1994) [Pubmed]
  6. Cutting Edge: TLR9 and TLR2 Signaling Together Account for MyD88-Dependent Control of Parasitemia in Trypanosoma cruzi Infection. Bafica, A., Santiago, H.C., Goldszmid, R., Ropert, C., Gazzinelli, R.T., Sher, A. J. Immunol. (2006) [Pubmed]
  7. A glycophospholipid anchor is required for Qa-2-mediated T cell activation. Robinson, P.J., Millrain, M., Antoniou, J., Simpson, E., Mellor, A.L. Nature (1989) [Pubmed]
  8. Genetic regulation of glucose phosphate isomerase in mouse oocytes. Peterson, A.C., Wong, G.G. Nature (1978) [Pubmed]
  9. Analysis of recombination in the centromere region of mouse chromosome 7 using ovarian teratoma and backcross methods. Eppig, J.T., Eicher, E.M. J. Hered. (1988) [Pubmed]
  10. Synthetic peptides related to the dermorphins. I. Synthesis and biological activities of the shorter homologues and of analogues of the heptapeptides. de Castiglione, R., Faoro, F., Perseo, G., Piani, S., Santangelo, F., Melchiorri, P., Falconieri Erspamer, G., Erspamer, V., Guglietta, A. Peptides (1981) [Pubmed]
  11. Alpha-2-adrenoceptor hyporesponsiveness in isolated tissues of cholestatic animals: involvement of opioid and nitric oxide systems. Demehri, S., Namiranian, K., Mehr, S.E., Rastegar, H., Shariftabrizi, A., Gaskari, S.A., Roushanzamir, F., Dehpour, A.R. Life Sci. (2003) [Pubmed]
  12. "Agouti NOD": identification of a CBA-derived Idd locus on Chromosome 7 and its use for chimera production with NOD embryonic stem cells. Chen, J., Reifsnyder, P.C., Scheuplein, F., Schott, W.H., Mileikovsky, M., Soodeen-Karamath, S., Nagy, A., Dosch, M.H., Ellis, J., Koch-Nolte, F., Leiter, E.H. Mamm. Genome (2005) [Pubmed]
  13. Genic heterogeneity and genetic monitoring of mouse outbred stocks. Groen, A., Lagerwerf, A.J. Lab. Anim. (1979) [Pubmed]
  14. Rapid induction of naive T cell apoptosis by ecto-nicotinamide adenine dinucleotide: requirement for mono(ADP-ribosyl)transferase 2 and a downstream effector. Adriouch, S., Ohlrogge, W., Haag, F., Koch-Nolte, F., Seman, M. J. Immunol. (2001) [Pubmed]
  15. Survival and normal function of glycolysis-deficient mouse oocytes. Kelly, A., West, J.D. Reproduction (2002) [Pubmed]
  16. The crystal structure of mouse phosphoglucose isomerase at 1.6A resolution and its complex with glucose 6-phosphate reveals the catalytic mechanism of sugar ring opening. Graham Solomons, J.T., Zimmerly, E.M., Burns, S., Krishnamurthy, N., Swan, M.K., Krings, S., Muirhead, H., Chirgwin, J., Davies, C. J. Mol. Biol. (2004) [Pubmed]
  17. Isoenzyme diversity in Pneumocystis carinii from rats, mice, and rabbits. Mazars, E., Guyot, K., Durand, I., Dei-Cas, E., Boucher, S., Abderrazak, S.B., Banuls, A.L., Tibayrenc, M., Camus, D. J. Infect. Dis. (1997) [Pubmed]
  18. Differential, LFA-1-sensitive effects of antibodies to nectadrin, the heat-stable antigen, on B lymphoblast aggregation and signal transduction. Kadmon, G., von Bohlen und Halbach, F., Schachner, M., Altevogt, P. Biochem. Biophys. Res. Commun. (1994) [Pubmed]
  19. Death of mouse embryos that lack a functional gene for glucose phosphate isomerase. West, J.D., Flockhart, J.H., Peters, J., Ball, S.T. Genet. Res. (1990) [Pubmed]
  20. Caveolar structure and protein sorting are maintained in NIH 3T3 cells independent of glycosphingolipid depletion. Shu, L., Lee, L., Chang, Y., Holzman, L.B., Edwards, C.A., Shelden, E., Shayman, J.A. Arch. Biochem. Biophys. (2000) [Pubmed]
  21. A new monoclonal antibody detects a developmentally regulated mouse ecto-ADP-ribosyltransferase on T cells: subset distribution, inbred strain variation, and modulation upon T cell activation. Koch-Nolte, F., Duffy, T., Nissen, M., Kahl, S., Killeen, N., Ablamunits, V., Haag, F., Leiter, E.H. J. Immunol. (1999) [Pubmed]
  22. Expression of glycophosphatidylinositol-anchored and -non-anchored isoforms of vascular cell adhesion molecule 1 in murine stromal and endothelial cells. Kinashi, T., St Pierre, Y., Springer, T.A. J. Leukoc. Biol. (1995) [Pubmed]
  23. Hybrids between Schistosoma mansoni and S. rodhaini: characterization by isoelectric focusing of six enzymes. Brémond, P., Théron, A., Rollinson, D. Parasitol. Res. (1989) [Pubmed]
  24. Genetic variation for prolidase (PEP-4) in the mouse maps near the gene for glucosephosphate isomerase (GPI-1) on chromosome 7. Skow, L.C. Biochem. Genet. (1981) [Pubmed]
  25. DNA sequence polymorphism in an androgen-regulated gene is associated with alteration in the encoded RNAs. Elliott, R.W., Berger, F.G. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
  26. Glucose-6-phosphate isomerase deficiency associated with nonspherocytic hemolytic anemia in the mouse: an animal model for the human disease. Merkle, S., Pretsch, W. Blood (1993) [Pubmed]
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