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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Qdpr  -  quinoid dihydropteridine reductase

Mus musculus

Synonyms: 2610008L04Rik, D5Ertd371e, Dhpr, Dihydropteridine reductase, HDHPR, ...
 
 
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Disease relevance of Qdpr

 

High impact information on Qdpr

  • When the x-ray structure of dihydropteridine reductase is correlated with conserved amino acid sequences characteristic of this enzyme class, two important common structural regions can be identified [2].
  • Assignment of a gene for human quinoid-dihydropteridine reductase (QDPR, EC 1.6.5.1) to chromosome 4 [3].
  • An acrylamide gel electrophoretic procedure is described which allows the separation of human quinoid-dihydropteridine reductase (QDPR), EC 1.6.5.1) from the homologous enzyme expressed in established rodent cell lines [3].

References

  1. NADH-specific dihydropteridine reductase in mastocytoma P-815 cells. Nakanisi, N., Kobayashi, H., Yamada, S. Comp. Biochem. Physiol., B (1984) [Pubmed]
  2. Structural and mechanistic characteristics of dihydropteridine reductase: a member of the Tyr-(Xaa)3-Lys-containing family of reductases and dehydrogenases. Varughese, K.I., Xuong, N.H., Kiefer, P.M., Matthews, D.A., Whiteley, J.M. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  3. Assignment of a gene for human quinoid-dihydropteridine reductase (QDPR, EC 1.6.5.1) to chromosome 4. Kuhl, P., Olek, K., Wardenbach, P., Grzeschik, K.H. Hum. Genet. (1979) [Pubmed]
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