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Gene Review

Qdpr  -  quinoid dihydropteridine reductase

Rattus norvegicus

Synonyms: Dhpr, Dihydropteridine reductase, HDHPR, Quinoid dihydropteridine reductase
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Disease relevance of Qdpr


Psychiatry related information on Qdpr


High impact information on Qdpr

  • This is of little value to dihydropteridine reductase but may be significant in the sequentially analogous short chain dehydrogenases/reductases, where a serine is the amino acid of choice for this position [6].
  • Kinetic constants for the interaction of NADH and NADPH with native rat dihydropteridine reductase (DHPR) and an Escherichia coli expressed mutant (D-37-I) have been determined [7].
  • Characterization and nucleotide binding properties of a mutant dihydropteridine reductase containing an aspartate 37-isoleucine replacement [7].
  • The cleavage of reductively alkylated rat liver dihydropteridine reductase with cyanogen bromide afforded a mixture of peptides, six of which (CB-1 to CB-6) were isolated and purified by C8 reverse-phase high performance liquid chromatography [8].
  • The pyridine dinucleotide-dependent dihydropteridine reductase from rat liver has been crystallized from various inorganic salts and from polyethylene glycol/ethanol mixtures using a vapor diffusion method [9].

Chemical compound and disease context of Qdpr

  • In one instance, that of a threonine insertion, a mutant construct of the rat analog has been expressed in Escherichia coli and the DHPR isolated and characterised, confirming the marked changes this insert can create [10].

Biological context of Qdpr


Anatomical context of Qdpr

  • The results indicate that the nonmutant recombinant rat DHPR is an authentic replica of the natural protein and that the characteristics of DHPR activity are determined by a single gene product and do not require specific modification via the eukaryotic cell [1].
  • Biochemical changes caused by the infusion into the substantia nigra of the rat of MPTP and related compounds which antagonise dihydropteridine reductase [5].
  • A fourth gene, quinoid dihydropteridine reductase was expressed at lower levels in white matter of the adolescent forebrain compared with the adult, but was not affected by nicotine [14].
  • Therefore, there would not appear to be any correlation between the ability to modify dopamine neuronal function, as assessed behaviourally or biochemically, and ability to inhibit DHPR in synaptosomes from the striatum of the rat in vitro [5].
  • The estimation of dihydropteridine reductase in human blood cells [15].

Associations of Qdpr with chemical compounds


Other interactions of Qdpr


Analytical, diagnostic and therapeutic context of Qdpr


  1. Role of aspartate-37 in determining cofactor specificity and binding in rat liver dihydropteridine reductase. Matthews, D.A., Varughese, K.I., Skinner, M., Xuong, N.H., Hoch, J., Trach, K., Schneider, M., Bray, T., Whiteley, J.M. Arch. Biochem. Biophys. (1991) [Pubmed]
  2. Activities of cerebral dihydropteridine reductase and tyrosine hydroxylase in chronic uremia in rats. Mullen, B.J., Wang, M. J. Nutr. (1986) [Pubmed]
  3. Antioxidation activity of tetrahydrobiopterin in pheochromocytoma PC 12 cells. Shen, R.S., Zhang, Y.X. Chem. Biol. Interact. (1991) [Pubmed]
  4. Regulation of GTP cyclohydrolase I and dihydropteridine reductase in rat pheochromocytoma PC 12 cells. Shen, R.S., Zhang, Y.X., Perez-Polo, J.R. J. Enzym. Inhib. (1989) [Pubmed]
  5. Biochemical changes caused by the infusion into the substantia nigra of the rat of MPTP and related compounds which antagonise dihydropteridine reductase. Bradbury, A.J., Brossi, A., Costall, B., Domeney, A.M., Gessner, W., Naylor, R.J. Neuropharmacology (1986) [Pubmed]
  6. Altered structural and mechanistic properties of mutant dihydropteridine reductases. Kiefer, P.M., Varughese, K.I., Su, Y., Xuong, N.H., Chang, C.F., Gupta, P., Bray, T., Whiteley, J.M. J. Biol. Chem. (1996) [Pubmed]
  7. Characterization and nucleotide binding properties of a mutant dihydropteridine reductase containing an aspartate 37-isoleucine replacement. Grimshaw, C.E., Matthews, D.A., Varughese, K.I., Skinner, M., Xuong, N.H., Bray, T., Hoch, J., Whiteley, J.M. J. Biol. Chem. (1992) [Pubmed]
  8. Structural studies and isolation of cDNA clones providing the complete sequence of rat liver dihydropteridine reductase. Shahbaz, M., Hoch, J.A., Trach, K.A., Hural, J.A., Webber, S., Whiteley, J.M. J. Biol. Chem. (1987) [Pubmed]
  9. Preliminary x-ray diffraction characterization of crystalline rat liver dihydropteridine reductase. Matthews, D.A., Webber, S., Whiteley, J.M. J. Biol. Chem. (1986) [Pubmed]
  10. Structural and mechanistic implications of incorporating naturally occurring aberrant mutations of human dihydropteridine reductase into a rat model. Varughese, K.I., Xuong, N.H., Whiteley, J.M. Int. J. Pept. Protein Res. (1994) [Pubmed]
  11. Identification of the 4-amino analogue of tetrahydrobiopterin as a dihydropteridine reductase inhibitor and a potent pteridine antagonist of rat neuronal nitric oxide synthase. Werner, E.R., Pitters, E., Schmidt, K., Wachter, H., Werner-Felmayer, G., Mayer, B. Biochem. J. (1996) [Pubmed]
  12. Inhibition of tyrosine hydroxylation in rat striatal tissue slices by 1-methyl-4-phenylpyridinium ion. Hirata, Y., Nagatsu, T. Neurosci. Lett. (1985) [Pubmed]
  13. Dihydropteridine reductase and tyrosine hydroxylase activities in rat brain during development and senescence: a comparative study. Algeri, S., Bonati, M., Brunello, N., Ponzio, F. Brain Res. (1977) [Pubmed]
  14. Differential expression of arc mRNA and other plasticity-related genes induced by nicotine in adolescent rat forebrain. Schochet, T.L., Kelley, A.E., Landry, C.F. Neuroscience (2005) [Pubmed]
  15. The estimation of dihydropteridine reductase in human blood cells. Webber, S., Hural, J.A., Whiteley, J.M. Clin. Chim. Acta (1988) [Pubmed]
  16. Preliminary studies on the primary structure of rat liver dihydropteridine reductase. Webber, S., Hural, J., Whiteley, J.M. Biochem. Biophys. Res. Commun. (1987) [Pubmed]
  17. Pyridine nucleotide interaction with rat liver dihydropteridine reductase. Webber, S., Whiteley, J.M. J. Biol. Chem. (1978) [Pubmed]
  18. The activity of 2,4,5-triamino-6-hydroxypyrimidine in the phenylalanine hydroxylase system. Kaufman, S. J. Biol. Chem. (1979) [Pubmed]
  19. Contrasting effects of N5-substituted tetrahydrobiopterin derivatives on phenylalanine hydroxylase, dihydropteridine reductase and nitric oxide synthase. Werner, E.R., Habisch, H.J., Gorren, A.C., Schmidt, K., Canevari, L., Werner-Felmayer, G., Mayer, B. Biochem. J. (2000) [Pubmed]
  20. Effect of chronic lead exposure on biopterin metabolism in the rat neostriatum. Martínez-Fong, D., Gutiérrez, M.E., Aceves, J. J. Neurosci. Res. (1990) [Pubmed]
  21. Short-term regulation of hydroxylase cofactor activity in rat brain. Mandell, A.J., Russo, P.V. J. Neurochem. (1981) [Pubmed]
  22. An enzyme immunoassay for the quantitation of dihydropteridine reductase. Kwan, S.W., Shen, R.S., Abell, C.W. Anal. Biochem. (1987) [Pubmed]
  23. Simultaneous simple purification of tyrosine hydroxylase and dihydropteridine reductase. Togari, A., Kano, H., Oka, K., Nagatsu, T. Anal. Biochem. (1983) [Pubmed]
  24. Multiple forms of rat-liver dihydropteridine reductase identified by their differing isoelectric points. Webber, S., Hural, J.A., Whiteley, J.M. Arch. Biochem. Biophys. (1986) [Pubmed]
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