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Gene Review

ntcB  -  nitrogen assimilation transcriptional...

Nostoc sp. PCC 7120

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Disease relevance of ntcB

  • A region of the genome of the heterocyst-forming cyanobacterium Anabaena sp. PCC 7120 containing the ntcB gene was identified [1].

High impact information on ntcB

  • Enzymes of the nitrate reduction system were not synthesized in the ntcB mutant under derepression conditions [1].
  • The transcription start-point of the Anabaena nir operon, which has been shown to be subjected to ammonium-stimulated repression and whose expression requires the global nitrogen regulator NtcA, was only weakly used in the ntcB mutant [1].
  • An Anabaena ntcB mutant was able to use ammonium and dinitrogen as sources of nitrogen for growth but was unable to assimilate nitrate [1].

Biological context of ntcB

  • In the genome of this cyanobacterium, the ntcB gene is found in a cluster of genes located in the complementary strand, upstream from the nir operon [2].


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