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Gene Review:

alr0957 - ferric uptake regulator

Nostoc sp. PCC 7120

Hernández, J.A. et al., Hernández, J.A. et al., Hernández, J.A. et al.

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Disease relevance of alr0957

DNA sequence analysis of the Anabaena sp. PCC7120 genome confirmed the presence of three open reading frames (all1691, all2473 and alr0957) containing the histidine-rich region characteristic of the Fur family [1].
In silico analysis of the promoter region of alr3808, a dpsA homologue from the cyanobacterium Nostoc sp. PCC7120 shows putative iron-boxes with high homology with those recognized by FurA (ferric uptake regulator) [2].

High impact information on alr0957

In prokaryotes, the family of Fur (ferric uptake regulator) proteins governs processes essential for the survival of microorganims such as the iron homeostasis [3].

References

Three fur homologues from Anabaena sp. PCC7120: exploring reciprocal protein-promoter recognition. Hernández, J.A., López-Gomollón, S., Bes, M.T., Fillat, M.F., Peleato, M.L. FEMS Microbiol. Lett. (2004) [Pubmed]
FurA modulates gene expression of alr3808, a DpsA homologue in Nostoc (Anabaena) sp. PCC7120. Hernández, J.A., Pellicer, S., Huang, L., Peleato, M.L., Fillat, M.F. FEBS Lett. (2007) [Pubmed]
Heme binds to and inhibits the DNA-binding activity of the global regulator FurA from Anabaena sp. PCC 7120. Hernández, J.A., Peleato, M.L., Fillat, M.F., Bes, M.T. FEBS Lett. (2004) [Pubmed]

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