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Gene Review

rbcL  -  ribulose bisophosphate carboxylase

Nostoc sp. PCC 7120

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Disease relevance of rbcL


High impact information on rbcL

  • In the filamentous cyanobacterium Anabaena, the gene for the small subunit (rbcS) of ribulose-1,5-bisphosphate carboxylase is linked to and transcribed together with the gene encoding the large subunit (rbcL) of the same enzyme [2].
  • We have identified a second DNA-binding activity (factor 2) that interacts with rbcL and xisA upstream regions [3].
  • DNase I footprint analysis of factor 2 binding to rbcL showed protection of a 63-bp region between positions -15 and -77 with respect to the transcription start site [3].
  • Expression of the ntcA gene, however, returned to normal levels 2 h after initiation of cold stress and increased significantly above normal levels 24 h after growth at 20 degrees C. The early decline in the expression of the ntcA, rbcR1, and rbcL/S transcripts appears to be part of the Anabaena 7120 global adaptation response to stress [4].
  • The rbcR1 transcript and its putative target gene ribulose 1,5-bisphosphate carboxylase/oxygenase (rbcL/S) were repressed by cold (20 degrees C) and osmotic (sucrose and salt) stress [4].

Chemical compound and disease context of rbcL


Biological context of rbcL

  • Comparison of the BifA binding sites on the glnA, xisA, and rbcL upstream regions revealed the consensus recognition sequence TGT(N9 or 10) ACA [3].

Other interactions of rbcL

  • Transcript levels of rbcR1, ntcA, and rbcL/S genes in cyanobacterium Anabaena sp. PCC 7120 are downregulated in response to cold and osmotic stress [4].


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