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Chemical Compound Review

KST-1B2210     (2,3-dihydroxy-4-oxo-5- phosphonooxy...

Synonyms: AC1L1AXB, AR-1B8178, AC1Q6S73, 24807-85-0, 1,5-di-o-phosphonopent-2-ulose
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Disease relevance of C01182

  • Comparison of the crystal structures of the L2 and L8S8 forms of ribulose-1,5-bisphosphate carboxylase from Rhodospirillum rubrum and spinach respectively, reveals a remarkable similarity in the overall architecture of the L2 building blocks in the two enzymes [1].
  • In RNA isolated from the endosymbiont there is a 10-fold reduction of GS transcript levels, a greater than 5-fold increase in 32-kd transcript levels and a greater than 5-fold decrease in RuBP carboxylase transcript levels, compared with levels in the free-living Anabaena azollae [2].
  • We have characterized the upstream nucleotide sequences involved in mRNA 3'-end formation in the 3' regions of the cauliflower mosaic virus (CaMV) 19S/35S transcription unit and a pea gene encoding ribulose-1,5-bisphosphate carboxylase small subunit (rbcS) [3].
  • Expression and assembly of active cyanobacterial ribulose-1,5-bisphosphate carboxylase/oxygenase in Escherichia coli containing stoichiometric amounts of large and small subunits [4].
  • A chemically synthesized gene encoding human CuZn superoxide dismutase (hSOD) was cloned into the shuttle vector pBAX18R and expressed in Anacystis nidulans 6301 (Synechococcus sp. strain PCC 6301) under the control of a ribulose-1,5-bisphosphate carboxylase/oxygenase gene (rbc) promoter derived from A. nidulans 6301 [5].

High impact information on C01182


Chemical compound and disease context of C01182


Biological context of C01182


Anatomical context of C01182

  • The light-inducible nuclear gene coding for the small subunit of ribulose-1,5-bisphosphate carboxylase (Rubisco), produces a precursor protein with an amino-terminal transit peptide which is transported into the plastids and cleaved by a specific proteinase [20].
  • We located the polypeptide nascent chain as it leaves cytoplasmic ribosomes from the plant Lemna gibba by immune electron microscopy using antibodies against the small subunit of the enzyme ribulose-1,5-bisphosphate carboxylase [21].
  • In cotyledons of light-grown seedlings and of dark-grown seedlings transferred into light for 5 hr (where ribulose-1,5-bisphosphate carboxylase synthesis was readily detected in vivo), the LSU and SSU mRNAs were associated with polysomes [22].
  • We show here that monocot (maize and wheat) but not dicot (pea, tobacco, and Arabidopsis) ribulose-1,5-bisphosphate carboxylase small subunit (rbcS) gene promoters are active in maize mesophyll protoplasts [23].
  • In order to determine if the cognate transit peptide of the light-harvesting chlorophyll a/b-binding protein (LHCP) is essential for LHCP import into the chloroplast and proper localization to the thylakoids, it was replaced with the transit peptide of the small subunit (S) of ribulose-1,5-bisphosphate carboxylase/oxygenase, a stromal protein [24].

Associations of C01182 with other chemical compounds


Gene context of C01182

  • Lines of transgenic Arabidopsis plants expressing antisense RNA for CCA1 showed reduced phytochrome induction of the endogenous Lhcb1*3 gene, whereas expression of another phytochrome-regulated gene, rbcS-1A, which encodes the small subunit of ribulose-1,5-bisphosphate carboxylase/oxygenase, was not affected [30].
  • To explore the role of individual residues in the small subunit of ribulose-1,5-bisphosphate carboxylase/oxygenase (EC, small subunits with single amino acid substitutions in three regions of relative sequence conservation were produced by directed mutagenesis of the rbcS gene from Anabaena 7120 [31].
  • In the filamentous cyanobacterium Anabaena, the gene for the small subunit (rbcS) of ribulose-1,5-bisphosphate carboxylase is linked to and transcribed together with the gene encoding the large subunit (rbcL) of the same enzyme [32].
  • Continuous light irradiation and fluence-response studies with the phyA-101 mutant show that phytochrome A functions in far-red light regulation of GAPA, GAPB, nuclear genes encoding small subunits of ribulose-1,5-bisphosphate carboxylase/oxygenase, and CAB genes [33].
  • Part of the large subunit of the ribulose-1,5-bisphosphate carboxylase/oxygenase (rubisco) gene (rbcL) was sequenced from three fern species: Adiantum capillus-veneris, Botrypus strictus, and Osmunda cinnamomea var. fokiensis [34].

Analytical, diagnostic and therapeutic context of C01182


  1. Comparison of the crystal structures of L2 and L8S8 Rubisco suggests a functional role for the small subunit. Schneider, G., Knight, S., Andersson, I., Brändén, C.I., Lindqvist, Y., Lundqvist, T. EMBO J. (1990) [Pubmed]
  2. Differences in mRNA levels in Anabaena living freely or in symbiotic association with Azolla. Nierzwicki-Bauer, S.A., Haselkorn, R. EMBO J. (1986) [Pubmed]
  3. Upstream sequences other than AAUAAA are required for efficient messenger RNA 3'-end formation in plants. Mogen, B.D., MacDonald, M.H., Graybosch, R., Hunt, A.G. Plant Cell (1990) [Pubmed]
  4. Expression and assembly of active cyanobacterial ribulose-1,5-bisphosphate carboxylase/oxygenase in Escherichia coli containing stoichiometric amounts of large and small subunits. Tabita, F.R., Small, C.L. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  5. High-level expression of human superoxide dismutase in the cyanobacterium Anacystis nidulans 6301. Takeshima, Y., Takatsugu, N., Sugiura, M., Hagiwara, H. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  6. Nine introns with conserved boundary sequences in the Euglena gracilis chloroplast ribulose-1,5-bisphosphate carboxylase gene. Koller, B., Gingrich, J.C., Stiegler, G.L., Farley, M.A., Delius, H., Hallick, R.B. Cell (1984) [Pubmed]
  7. Maize mitochondrial DNA contains a sequence homologous to the ribulose-1,5-bisphosphate carboxylase large subunit gene of chloroplast DNA. Lonsdale, D.M., Hodge, T.P., Howe, C.J., Stern, D.B. Cell (1983) [Pubmed]
  8. Sliding-layer conformational change limited by the quaternary structure of plant RuBisCO. Chapman, M.S., Suh, S.W., Cascio, D., Smith, W.W., Eisenberg, D. Nature (1987) [Pubmed]
  9. A plant basal in vitro system supporting accurate transcription of both RNA polymerase II- and III-dependent genes: supplement of green leaf component(s) drives accurate transcription of a light-responsive rbcS gene. Fan, H., Sugiura, M. EMBO J. (1995) [Pubmed]
  10. Crystal structure of the binary complex of ribulose-1,5-bisphosphate carboxylase and its product, 3-phospho-D-glycerate. Lundqvist, T., Schneider, G. J. Biol. Chem. (1989) [Pubmed]
  11. Glycine 176 affects catalytic properties and stability of the Synechococcus sp. strain PCC6301 ribulose-1,5-bisphosphate carboxylase/oxygenase. Smith, S.A., Tabita, F.R. J. Biol. Chem. (2004) [Pubmed]
  12. Site-specific mutagenesis of ribulose-1,5-bisphosphate carboxylase/oxygenase. Evidence that carbamate formation at Lys 191 is required for catalytic activity. Estelle, M., Hanks, J., McIntosh, L., Somerville, C. J. Biol. Chem. (1985) [Pubmed]
  13. Mutation of asparagine 111 of rubisco from Rhodospirillum rubrum alters the carboxylase/oxygenase specificity. Chène, P., Day, A.G., Fersht, A.R. J. Mol. Biol. (1992) [Pubmed]
  14. Preliminary crystallographic study of a ribulose-1,5-bisphosphate carboxylase-oxygenase from Chromatium vinosum. Nakagawa, H., Sugimoto, M., Kai, Y., Harada, S., Miki, K., Kasai, N., Saeki, K., Kakuno, T., Horio, T. J. Mol. Biol. (1986) [Pubmed]
  15. NH2-terminal amino acid sequences of precursor and mature forms of the ribulose-1,5-bisphosphate carboxylase small subunit from Chlamydomonas reinhardtii. Schmidt, G.W., Devillers-Thiery, A., Desruisseaux, H., Blobel, G., Chua, N.H. J. Cell Biol. (1979) [Pubmed]
  16. Tissue-specific and light-regulated expression of a pea nuclear gene encoding the small subunit of ribulose-1,5-bisphosphate carboxylase. Coruzzi, G., Broglie, R., Edwards, C., Chua, N.H. EMBO J. (1984) [Pubmed]
  17. Chloroplast-cytoplasmic interrelations involved in chloroplast development in Chlamydomonas reinhardi y-1: effect of selective depletion of chloroplast translates. Gershoni, J.M., Ohad, I. J. Cell Biol. (1980) [Pubmed]
  18. Regulation of genes encoding the large subunit of ribulose-1,5-bisphosphate carboxylase and the photosystem II polypeptides D-1 and D-2 during the cell cycle of Chlamydomonas reinhardtii. Herrin, D.L., Michaels, A.S., Paul, A.L. J. Cell Biol. (1986) [Pubmed]
  19. Binding sites for two novel phosphoproteins, 3AF5 and 3AF3, are required for rbcS-3A expression. Sarokin, L.P., Chua, N.H. Plant Cell (1992) [Pubmed]
  20. The use of nuclear-encoded sequences to direct the light-regulated synthesis and transport of a foreign protein into plant chloroplasts. Schreier, P.H., Seftor, E.A., Schell, J., Bohnert, H.J. EMBO J. (1985) [Pubmed]
  21. Nascent polypeptide chains exit the ribosome in the same relative position in both eucaryotes and procaryotes. Bernabeu, C., Tobin, E.M., Fowler, A., Zabin, I., Lake, J.A. J. Cell Biol. (1983) [Pubmed]
  22. Light-mediated control of translational initiation of ribulose-1, 5-bisphosphate carboxylase in amaranth cotyledons. Berry, J.O., Breiding, D.E., Klessig, D.F. Plant Cell (1990) [Pubmed]
  23. Maize rbcS promoter activity depends on sequence elements not found in dicot rbcS promoters. Schäffner, A.R., Sheen, J. Plant Cell (1991) [Pubmed]
  24. The chlorophyll a/b-binding protein inserts into the thylakoids independent of its cognate transit peptide. Lamppa, G.K. J. Biol. Chem. (1988) [Pubmed]
  25. Structural transitions during activation and ligand binding in hexadecameric Rubisco inferred from the crystal structure of the activated unliganded spinach enzyme. Taylor, T.C., Andersson, I. Nat. Struct. Biol. (1996) [Pubmed]
  26. Identification and cloning of the chloroplast gene coding for the large subunit of ribulose-1,5-bisphosphate carboxylase from Chlamydomonas reinhardi. Gelvin, S., Heizmann, P., Howell, S.H. Proc. Natl. Acad. Sci. U.S.A. (1977) [Pubmed]
  27. Active site studies of ribulose-1,5-bisphosphate carboxylase/oxygenase with pyridoxal 5'-phosphate. Paech, C., Tolbert, N.E. J. Biol. Chem. (1978) [Pubmed]
  28. The orientation of substrate and reaction intermediates in the active site of ribulose-1,5-bisphosphate carboxylase. Lorimer, G.H., Gutteridge, S., Reddy, G.S. J. Biol. Chem. (1989) [Pubmed]
  29. Oxidative stress causes rapid membrane translocation and in vivo degradation of ribulose-1,5-bisphosphate carboxylase/oxygenase. Mehta, R.A., Fawcett, T.W., Porath, D., Mattoo, A.K. J. Biol. Chem. (1992) [Pubmed]
  30. A Myb-related transcription factor is involved in the phytochrome regulation of an Arabidopsis Lhcb gene. Wang, Z.Y., Kenigsbuch, D., Sun, L., Harel, E., Ong, M.S., Tobin, E.M. Plant Cell (1997) [Pubmed]
  31. Residues in three conserved regions of the small subunit of ribulose-1,5-bisphosphate carboxylase/oxygenase are required for quaternary structure. Fitchen, J.H., Knight, S., Andersson, I., Branden, C.I., McIntosh, L. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  32. Cotranscription of genes encoding the small and large subunits of ribulose-1,5-bisphosphate carboxylase in the cyanobacterium Anabaena 7120. Nierzwicki-Bauer, S.A., Curtis, S.E., Haselkorn, R. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
  33. Effects of light and chloroplast functional state on expression of nuclear genes encoding chloroplast glyceraldehyde-3-phosphate dehydrogenase in long hypocotyl (hy) mutants and wild-type Arabidopsis thaliana. Conley, T.R., Shih, M.C. Plant Physiol. (1995) [Pubmed]
  34. Phylogenetic relationships of ferns deduced from rbcL gene sequence. Hasebe, M., Ito, M., Kofuji, R., Ueda, K., Iwatsuki, K. J. Mol. Evol. (1993) [Pubmed]
  35. The gene for the small subunit of ribulose-1,5-bisphosphate carboxylase/oxygenase is located close to the gene for the large subunit in the cyanobacterium Anacystis nidulans 6301. Shinozaki, K., Sugiura, M. Nucleic Acids Res. (1983) [Pubmed]
  36. Crystallization of the activated ternary complex of ribulose-1,5-bisphosphate carboxylase-oxygenase isolated from Rhodospirillum rubrum and from an Escherichia coli clone. Choe, H.W., Jakob, R., Hahn, U., Pal, G.P. J. Mol. Biol. (1985) [Pubmed]
  37. Role of jasmonate in the rice (Oryza sativa L.) self-defense mechanism using proteome analysis. Rakwal, R., Komatsu, S. Electrophoresis (2000) [Pubmed]
  38. The activation of ribulose-1,5-bisphosphate carboxylase by carbon dioxide and magnesium ions. Equilibria, kinetics, a suggested mechanism, and physiological implications. Lorimer, G.H., Badger, M.R., Andrews, T.J. Biochemistry (1976) [Pubmed]
  39. D-Ribulose-1,5-bisphosphate carboxylase and polyhedral inclusion bodies in Thiobacillus intermedius. Purohit, K., McFadden, B.A., Shaykh, M.M. J. Bacteriol. (1976) [Pubmed]
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