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Gene Review:

Hba-ps4 - hemoglobin alpha, pseudogene 4

Mus musculus

This record was replaced with 383229.

D'Eustachio, P. et al., Ark, B. et al., Himmelbauer, H. et al., Rossi, J.M. et al., Tan, H. et al., et al.

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High impact information on Hba-ps4

Analysis of Hba-a4 alleles in CXB, BXH, and AKXL recombinant inbred strains placed Hba-a4 6.60 +/- 3.14 cM centromeric to H-2 [1].
We have now further characterized the second of these pseudogenes, Hba-a4 [1].
Hba-a4 is the first mammalian dispersed pseudogene to be localized in a linkage map, and should provide a useful marker for the region of chromosome 17 proximal to H-2 [1].
The usefulness of the library for chromosome walking was illustrated by constructing a 600-kilobase-long contig of DNA surrounding Hba-ps4, a DNA marker that is tightly linked to the fused (Fu) locus on chromosome 17 [2].
A parsimony analysis was performed on restriction sites at the Hba-ps4 pseudogene locus within one of four inversions associated with mouse t haplotypes [3].

Biological context of Hba-ps4

Several other loci have been identified previously that are also closely linked to the human alpha-globin locus but near the alpha-globin pseudogene Hba-ps4 in the mouse [4].
We have sequenced and fully annotated a 65,871-bp region of mouse Chromosome 17 including the Hba-ps4 alpha-globin pseudogene [5].

Anatomical context of Hba-ps4

Results obtained with the BXD recombinant strain system and somatic cell hybrids show the homologous region to be located on mouse chromosome 17 near the globin pseudogene Hba-ps4, an unprocessed alpha-like globin gene [6].

Other interactions of Hba-ps4

Pim-1 was previously mapped to chromosome 17 by somatic cell hybrids, and subsequently to the region between the hemoglobin alpha-chain pseudogene 4 (Hba-4ps) and the alpha-crystalline gene (Crya-1) by Southern blot analysis of DNA obtained from panels of recombinant inbred strains [7].

Analytical, diagnostic and therapeutic context of Hba-ps4

Higher resolution restriction mapping and sequence analysis was also performed for alleles at the Hba-ps4 locus [8].

References

The alpha-globin pseudogene on mouse chromosome 17 is closely linked to H-2. D'Eustachio, P., Fein, B., Michaelson, J., Taylor, B.A. J. Exp. Med. (1984) [Pubmed]
Genomic analysis using a yeast artificial chromosome library with mouse DNA inserts. Rossi, J.M., Burke, D.T., Leung, J.C., Koos, D.S., Chen, H., Tilghman, S.M. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
Phylogenetic analysis of the alpha-globin pseudogene-4 (Hba-ps4) locus in the house mouse species complex reveals a stepwise evolution of t haplotypes. Hammer, M.F., Silver, L.M. Mol. Biol. Evol. (1993) [Pubmed]
Genomic rearrangement of the alpha-globin gene complex during mammalian evolution. Tan, H., Whitney, J.B. Biochem. Genet. (1993) [Pubmed]
Comparative analysis of the alpha-like globin clusters in mouse, rat, and human chromosomes indicates a mechanism underlying breaks in conserved synteny. Tufarelli, C., Hardison, R., Miller, W., Hughes, J., Clark, K., Ventress, N., Frischauf, A.M., Higgs, D.R. Genome Res. (2004) [Pubmed]
Human-mouse homologies in the region of the polycystic kidney disease gene (PKD1). Himmelbauer, H., Pohlschmidt, M., Snarey, A., Germino, G.G., Weinstat-Saslow, D., Somlo, S., Reeders, S.T., Frischauf, A.M. Genomics (1992) [Pubmed]
Mapping of the Pim-1 oncogene in mouse t-haplotypes and its use to define the relative map positions of the tcl loci t0(t6) and tw12 and the marker tf (tufted). Ark, B., Gummere, G., Bennett, D., Artzt, K. Genomics (1991) [Pubmed]
Genetic exchange across a paracentric inversion of the mouse t complex. Hammer, M.F., Bliss, S., Silver, L.M. Genetics (1991) [Pubmed]

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