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Gene Review

Cryaa  -  crystallin, alpha A

Mus musculus

Synonyms: AI323437, Acry-1, Alpha-crystallin A chain, Crya-1, Crya1, ...
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Disease relevance of Cryaa


High impact information on Cryaa


Chemical compound and disease context of Cryaa


Biological context of Cryaa


Anatomical context of Cryaa


Associations of Cryaa with chemical compounds


Physical interactions of Cryaa

  • A partial cDNA with sequence similarity to alpha A-CRYPB1 of the mouse has been isolated from a chicken lens library; mouse alpha A-CRYBP1 is a putative transcription factor which binds to the -66/-55 sequence of the mouse alpha A-crystallin promoter.(ABSTRACT TRUNCATED AT 250 WORDS)[19]

Regulatory relationships of Cryaa


Other interactions of Cryaa


Analytical, diagnostic and therapeutic context of Cryaa


  1. Developmental genetics in ophthalmology. Graw, J., Löster, J. Ophthalmic Genet. (2003) [Pubmed]
  2. Regulation of the mouse alpha A-crystallin gene: isolation of a cDNA encoding a protein that binds to a cis sequence motif shared with the major histocompatibility complex class I gene and other genes. Nakamura, T., Donovan, D.M., Hamada, K., Sax, C.M., Norman, B., Flanagan, J.R., Ozato, K., Westphal, H., Piatigorsky, J. Mol. Cell. Biol. (1990) [Pubmed]
  3. Trilateral tumors in four different lines of transgenic mice expressing SV40 T-antigen. Marcus, D.M., Lasudry, J.G., Carpenter, J.L., Windle, J., Howes, K.A., al-Ubaidi, M.R., Baehr, W., Overbeek, P.A., Font, R.L., Albert, D.M. Invest. Ophthalmol. Vis. Sci. (1996) [Pubmed]
  4. Demyelination and axonal dystrophy in alpha A-crystallin transgenic mice. De Rijk, E.P., Van Rijk, A.F., Van Esch, E., De Jong, W.W., Wesseling, P., Bloemendal, H. International journal of experimental pathology. (2000) [Pubmed]
  5. Alternative RNA splicing of the murine alpha A-crystallin gene: protein-coding information within an intron. King, C.R., Piatigorsky, J. Cell (1983) [Pubmed]
  6. Lens-specific expression of recombinant ricin induces developmental defects in the eyes of transgenic mice. Landel, C.P., Zhao, J., Bok, D., Evans, G.A. Genes Dev. (1988) [Pubmed]
  7. Targeted disruption of the mouse alpha A-crystallin gene induces cataract and cytoplasmic inclusion bodies containing the small heat shock protein alpha B-crystallin. Brady, J.P., Garland, D., Duglas-Tabor, Y., Robison, W.G., Groome, A., Wawrousek, E.F. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  8. Pax-6 and lens-specific transcription of the chicken delta 1-crystallin gene. Cvekl, A., Sax, C.M., Li, X., McDermott, J.B., Piatigorsky, J. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  9. Gene transactivation mediated by the TAT gene of human immunodeficiency virus in transgenic mice. Khillan, J.S., Deen, K.C., Yu, S.H., Sweet, R.W., Rosenberg, M., Westphal, H. Nucleic Acids Res. (1988) [Pubmed]
  10. Transcriptional regulation of the mouse alpha A-crystallin gene: activation dependent on a cyclic AMP-responsive element (DE1/CRE) and a Pax-6-binding site. Cvekl, A., Kashanchi, F., Sax, C.M., Brady, J.N., Piatigorsky, J. Mol. Cell. Biol. (1995) [Pubmed]
  11. FGF suppresses apoptosis and induces differentiation of fibre cells in the mouse lens. Chow, R.L., Roux, G.D., Roghani, M., Palmer, M.A., Rifkin, D.B., Moscatelli, D.A., Lang, R.A. Development (1995) [Pubmed]
  12. The putative oncogene Pim-1 in the mouse: its linkage and variation among t haplotypes. Nadeau, J.H., Phillips, S.J. Genetics (1987) [Pubmed]
  13. The alpha-A-crystallin and cystathionine beta-synthase genes are physically very closely linked in proximal mouse chromosome 17. Stubbs, L., Kraus, J., Lehrach, H. Genomics (1990) [Pubmed]
  14. The locus encoding alpha A-crystallin is closely linked to H-2K on mouse chromosome 17. Skow, L.C., Donner, M.E. Genetics (1985) [Pubmed]
  15. Differential expression of alpha A- and alpha B-crystallin during murine ocular development. Robinson, M.L., Overbeek, P.A. Invest. Ophthalmol. Vis. Sci. (1996) [Pubmed]
  16. Alpha A-crystallin confers cellular thermoresistance. van den IJssel, P.R., Overkamp, P., Knauf, U., Gaestel, M., de Jong, W.W. FEBS Lett. (1994) [Pubmed]
  17. Lens-specific expression of the chloramphenicol acetyltransferase gene promoted by 5' flanking sequences of the murine alpha A-crystallin gene in explanted chicken lens epithelia. Chepelinsky, A.B., King, C.R., Zelenka, P.S., Piatigorsky, J. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  18. Protein-DNA interactions of the mouse alpha A-crystallin control regions. Differences between expressing and non-expressing cells. Kantorow, M., Cvekl, A., Sax, C.M., Piatigorsky, J. J. Mol. Biol. (1993) [Pubmed]
  19. Conservation of mouse alpha A-crystallin promoter activity in chicken lens epithelial cells. Donovan, D.M., Sax, C.M., Klement, J.F., Li, X., Chepelinsky, A.B., Piatigorsky, J. J. Mol. Evol. (1992) [Pubmed]
  20. Murine transcription factor alpha A-crystallin binding protein I. Complete sequence, gene structure, expression, and functional inhibition via antisense RNA. Brady, J.P., Kantorow, M., Sax, C.M., Donovan, D.M., Piatigorsky, J. J. Biol. Chem. (1995) [Pubmed]
  21. Aphakia (ak), a mouse mutation affecting early eye development: fine mapping, consideration of candidate genes and altered Pax6 and Six3 gene expression pattern. Grimm, C., Chatterjee, B., Favor, J., Immervoll, T., Löster, J., Klopp, N., Sandulache, R., Graw, J. Dev. Genet. (1998) [Pubmed]
  22. Limits of the distal inversion in the t complex of the house mouse: evidence from linkage disequilibria. Neufeld, E., Vincek, V., Figueroa, F., Klein, J. Mamm. Genome (1991) [Pubmed]
  23. Characterization of a new, dominant V124E mutation in the mouse alphaA-crystallin-encoding gene. Graw, J., Löster, J., Soewarto, D., Fuchs, H., Meyer, B., Reis, A., Wolf, E., Balling, R., Hrabé de Angelis, M. Invest. Ophthalmol. Vis. Sci. (2001) [Pubmed]
  24. Binding of tissue-specific forms of alpha A-CRYBP1 to their regulatory sequence in the mouse alpha A-crystallin-encoding gene: double-label immunoblotting of UV-crosslinked complexes. Kantorow, M., Becker, K., Sax, C.M., Ozato, K., Piatigorsky, J. Gene (1993) [Pubmed]
  25. Reduced levels of gamma-crystallin transcripts during embryonic development of murine Cat2nop mutant lenses. Santhiya, S.T., Abd-alla, S.M., Löster, J., Graw, J. Graefes Arch. Clin. Exp. Ophthalmol. (1995) [Pubmed]
  26. Regional assignment of the mouse alpha A2-crystallin gene (Crya-1) to chromosome 17A3----B by in situ hybridization. Kaye, N.W., Lalley, P.A., Petrash, J.M., Church, R.L. Cytogenet. Cell Genet. (1990) [Pubmed]
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