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Gene Review:

PRDM5 - PR domain containing 5

Homo sapiens

Synonyms: BCS2, PFM2, PR domain zinc finger protein 5, PR domain-containing protein 5

Deng, Q. et al., Watanabe, Y. et al.

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Disease relevance of PRDM5

A recombinant adenovirus expressing PRDM5 caused G2/M arrest and apoptosis upon infection of tumor cells [1].
Among the 17 PRDM family genes tested, we found that PRDM5 is the most frequently silenced in colorectal and gastric cancer cell lines [2].

High impact information on PRDM5

A PRDM5 cDNA was isolated based on its homology to the PR domain of RIZ1 (PRDM2) [1].
Radiation hybrid analysis mapped PRDM5 to human chromosome 4q26, a region thought to harbor tumor suppressor genes for breast, ovarian, liver, lung, colon, and other cancers [1].

References

PRDM5 is silenced in human cancers and has growth suppressive activities. Deng, Q., Huang, S. Oncogene (2004) [Pubmed]
PRDM5 identified as a target of epigenetic silencing in colorectal and gastric cancer. Watanabe, Y., Toyota, M., Kondo, Y., Suzuki, H., Imai, T., Ohe-Toyota, M., Maruyama, R., Nojima, M., Sasaki, Y., Sekido, Y., Hiratsuka, H., Shinomura, Y., Imai, K., Itoh, F., Tokino, T. Clin. Cancer Res. (2007) [Pubmed]

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