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Gene Review

TBC1D8  -  TBC1 domain family, member 8 (with GRAM...

Homo sapiens

Synonyms: AD 3, AD3, HBLP1, TBC1 domain family member 8, TBC1D8A, ...
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High impact information on TBC1D8

  • Cell free assay of alpha-galactosyltransferase activity revealed that the Vero cell clone (VRP) contained significantly reduced enzyme activity, whereas in the case of the Daudi mutant (VT20), no significant decrease in activity was noted in vitro [1].
  • The remainder of AD-3 was extracted in ethyl acetate after its hydrolysis with 2 M HCl [2].
  • AD-3 at 1000 ppm stimulated root and shoot growth by about 2.4 and 1.5 times over the respective water and sucrose-treated controls [2].

Associations of TBC1D8 with chemical compounds

  • After partial hydrolysis with 0.2 M trifluoroacetic acid or by a sodium periodate treatment, the activity of AD-3 had completely disappeared, suggesting that the sugar moiety and/or molecular size were important for the activity [2].

Analytical, diagnostic and therapeutic context of TBC1D8


  1. Verotoxin-resistant cell clones are deficient in the glycolipid globotriosylceramide: differential basis of phenotype. Pudymaitis, A., Armstrong, G., Lingwood, C.A. Arch. Biochem. Biophys. (1991) [Pubmed]
  2. Growth promotion of rice seedlings by allelopathic polysaccharide from Welsh onion. Goo, G.C., Choi, S.T., Ahn, H.G., Song, K.S. Biosci. Biotechnol. Biochem. (2001) [Pubmed]
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