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Gene Review

BAZ1A  -  bromodomain adjacent to zinc finger domain...

Homo sapiens

Synonyms: ACF1, ATP-dependent chromatin-remodeling protein, ATP-utilizing chromatin assembly and remodeling factor 1, Bromodomain adjacent to zinc finger domain protein 1A, CHRAC subunit ACF1, ...
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High impact information on BAZ1A

  • Our data suggest that an ACF1-SNF2H complex is part of a dedicated mechanism that enables DNA replication through highly condensed regions of chromatin [1].
  • ACF1 (ATP-utilizing chromatin assembly and remodeling factor 1) and an ISWI isoform, SNF2H (sucrose nonfermenting-2 homolog), become specifically enriched in replicating pericentromeric heterochromatin [1].
  • Accordingly, depletion of ACF1 causes a delay in cell-cycle progression through the late stages of S phase [1].
  • However, the addition of recombinant SU(VAR) protein, such as ACF1 or SU(VAR)3-9, facilitates HP1 binding to chromatin methylated at lysine 9 within the H3 N terminus (H3K9) [2].
  • In contrast, the SWI/SNF complex and its ATPase subunit BRG1 generated DNA accessibility profiles that were similar to each other, but different significantly from those of hACF and SNF2h [3].

Biological context of BAZ1A


Other interactions of BAZ1A

  • In addition, recombinant ACF composed of imitation switch and Acf1 can extend closely packed nucleosomes, which suggests that recombinant ACF can mobilize nucleosomes [4].


  1. An ACF1-ISWI chromatin-remodeling complex is required for DNA replication through heterochromatin. Collins, N., Poot, R.A., Kukimoto, I., García-Jiménez, C., Dellaire, G., Varga-Weisz, P.D. Nat. Genet. (2002) [Pubmed]
  2. HP1 Binding to Chromatin Methylated at H3K9 Is Enhanced by Auxiliary Factors. Eskeland, R., Eberharter, A., Imhof, A. Mol. Cell. Biol. (2007) [Pubmed]
  3. Human ACF1 Alters the Remodeling Strategy of SNF2h. He, X., Fan, H.Y., Narlikar, G.J., Kingston, R.E. J. Biol. Chem. (2006) [Pubmed]
  4. Multistep chromatin assembly on supercoiled plasmid DNA by nucleosome assembly protein-1 and ATP-utilizing chromatin assembly and remodeling factor. Nakagawa, T., Bulger, M., Muramatsu, M., Ito, T. J. Biol. Chem. (2001) [Pubmed]
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