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Gene Review

SMARCA5  -  SWI/SNF related, matrix associated, actin...

Homo sapiens

Synonyms: ISWI, SNF2H, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin A5, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5, Sucrose nonfermenting protein 2 homolog, ...
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Disease relevance of SMARCA5


High impact information on SMARCA5

  • Our data suggest that an ACF1-SNF2H complex is part of a dedicated mechanism that enables DNA replication through highly condensed regions of chromatin [2].
  • In vivo depletion of SNF2H slows the progression of DNA replication throughout S phase, indicating a functional overlap with ACF1 [2].
  • The majority of the latter are components of the human transcription complexes TFIID (including TBP), SWI/SNF, NuRD, hSNF2H, and Sin3A [3].
  • WSTF, in turn, recruits imitation switch (ISWI)-type nucleosome-remodelling factor SNF2H to replication sites [4].
  • N-CoR and HDAC3 are both required for recruitment of SNF2H to the repressed gene [5].

Biological context of SMARCA5


Anatomical context of SMARCA5

  • Consistent with these findings, reduction of SNF2H induces expression of an endogenous TR-regulated gene, dio1, in liver cells [5].

Associations of SMARCA5 with chemical compounds


Physical interactions of SMARCA5


Other interactions of SMARCA5

  • CBP, PCAF, Brg-1, SNF2H and FACT were recruited to the coding regions in a gene-specific manner, in a similarly restricted promoter-proximal pattern [9].
  • Functional differences between the human ATP-dependent nucleosome remodeling proteins BRG1 and SNF2H [10].
  • The pronounced expression of the mammalian imitation switch (ISWI) genes, SNF2H and SNF2L, in adult ovaries prompted us to investigate the role of these chromatin remodeling proteins during follicular development and luteinization [6].

Analytical, diagnostic and therapeutic context of SMARCA5

  • Northern-blot analysis demonstrated ubiquitous expression of 5.1-kb and 4.1-kb transcripts of the hSNF2H gene [7].


  1. Chromatin remodeling gene SMARCA5 is dysregulated in primitive hematopoietic cells of acute leukemia. Stopka, T., Zakova, D., Fuchs, O., Kubrova, O., Blafkova, J., Jelinek, J., Necas, E., Zivny, J. Leukemia (2000) [Pubmed]
  2. An ACF1-ISWI chromatin-remodeling complex is required for DNA replication through heterochromatin. Collins, N., Poot, R.A., Kukimoto, I., García-Jiménez, C., Dellaire, G., Varga-Weisz, P.D. Nat. Genet. (2002) [Pubmed]
  3. ALL-1 is a histone methyltransferase that assembles a supercomplex of proteins involved in transcriptional regulation. Nakamura, T., Mori, T., Tada, S., Krajewski, W., Rozovskaia, T., Wassell, R., Dubois, G., Mazo, A., Croce, C.M., Canaani, E. Mol. Cell (2002) [Pubmed]
  4. The Williams syndrome transcription factor interacts with PCNA to target chromatin remodelling by ISWI to replication foci. Poot, R.A., Bozhenok, L., van den Berg, D.L., Steffensen, S., Ferreira, F., Grimaldi, M., Gilbert, N., Ferreira, J., Varga-Weisz, P.D. Nat. Cell Biol. (2004) [Pubmed]
  5. The N-CoR complex enables chromatin remodeler SNF2H to enhance repression by thyroid hormone receptor. Alenghat, T., Yu, J., Lazar, M.A. EMBO J. (2006) [Pubmed]
  6. The Imitation Switch Protein SNF2L Regulates Steroidogenic Acute Regulatory Protein Expression during Terminal Differentiation of Ovarian Granulosa Cells. Lazzaro, M.A., P??pin, D., Pescador, N., Murphy, B.D., Vanderhyden, B.C., Picketts, D.J. Mol. Endocrinol. (2006) [Pubmed]
  7. Cloning and mapping of SMARCA5 encoding hSNF2H, a novel human homologue of Drosophila ISWI. Aihara, T., Miyoshi, Y., Koyama, K., Suzuki, M., Takahashi, E., Monden, M., Nakamura, Y. Cytogenet. Cell Genet. (1998) [Pubmed]
  8. DNMT3B interacts with hSNF2H chromatin remodeling enzyme, HDACs 1 and 2, and components of the histone methylation system. Geiman, T.M., Sankpal, U.T., Robertson, A.K., Zhao, Y., Zhao, Y., Robertson, K.D. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  9. Histone modifications defining active genes persist after transcriptional and mitotic inactivation. Kouskouti, A., Talianidis, I. EMBO J. (2005) [Pubmed]
  10. Functional differences between the human ATP-dependent nucleosome remodeling proteins BRG1 and SNF2H. Aalfs, J.D., Narlikar, G.J., Kingston, R.E. J. Biol. Chem. (2001) [Pubmed]
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