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Gene Review

ANXA10  -  annexin A10

Homo sapiens

Synonyms: ANX14, Annexin A10, Annexin-10, Annexin-14
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Disease relevance of ANXA10


High impact information on ANXA10

  • The most up-regulated genes in BE compared with squamous epithelium were trefoil factors, annexin A10, and galectin-4 [2].
  • Down-regulation of ANXA10 was twofold more frequent in large than small HCCs (P = 0.0012), in grade II to III than grade I HCC (P < 0.00001), and in stage IIIA to IV than stage I to II HCC (P < 0.00001) [1].
  • Our results indicate that the expression of the tissue- and tumor-restricted ANXA10 is a marker of liver cell differentiation and growth arrest, and its down-regulation associated with malignant phenotype of hepatocytes, vascular invasion, and progression of HCC, leading to poor prognosis [1].

Biological context of ANXA10

  • Of 182 unifocal primary HCCs, ANXA10 mRNA was dramatically reduced in 121 (66%), and the down-regulation correlated with p53 mutation (P = 0.024), early intrahepatic tumor recurrence (P = 0.0007), and lower 4-year survival (P = 0.0014) [1].

Other interactions of ANXA10


Analytical, diagnostic and therapeutic context of ANXA10


  1. Down-regulation of annexin A10 in hepatocellular carcinoma is associated with vascular invasion, early recurrence, and poor prognosis in synergy with p53 mutation. Liu, S.H., Lin, C.Y., Peng, S.Y., Jeng, Y.M., Pan, H.W., Lai, P.L., Liu, C.L., Hsu, H.C. Am. J. Pathol. (2002) [Pubmed]
  2. A comparative analysis by SAGE of gene expression profiles of Barrett's esophagus, normal squamous esophagus, and gastric cardia. van Baal, J.W., Milano, F., Rygiel, A.M., Bergman, J.J., Rosmolen, W.D., van Deventer, S.J., Wang, K.K., Peppelenbosch, M.P., Krishnadath, K.K. Gastroenterology (2005) [Pubmed]
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