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Gene Review

TREX2  -  three prime repair exonuclease 2

Homo sapiens

Synonyms: 3'-5' exonuclease TREX2, Three prime repair exonuclease 2
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Disease relevance of TREX2


High impact information on TREX2

  • We now find the 3'-to-5' exonuclease TREX1, but not its close homolog TREX2, in the SET complex [2].
  • Symmetry in the TREX2 dimer positions the active sites at opposite outer edges providing open access for the DNA [3].
  • The human TREX2 catalytic residues overlay with the bacterial DnaQ family of 3'-exonucleases confirming the structural conservation of the catalytic sites despite limited sequence identity, and mutations of these residues decrease the still measurable activity by approximately 10(5)-fold, confirming their catalytic role [3].
  • The mammalian TREX1 and TREX2 proteins contain potent 3'-->5' exonucleases capable of functioning in this capacity [4].
  • An exonuclease competition assay was designed using heparin as a nonsubstrate inhibitor with a series of partial duplex DNAs to delineate the substrate structure preferences for 3' nucleotide excision by Trex1 and TREX2 [4].

Biological context of TREX2


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