Gene Review:
TREX1 - three prime repair exonuclease 1
Homo sapiens
Synonyms:
3'-5' exonuclease TREX1, AGS1, CRV, DNase III, DRN3, ...
- Identification and expression of the TREX1 and TREX2 cDNA sequences encoding mammalian 3'-->5' exonucleases. Mazur, D.J., Perrino, F.W. J. Biol. Chem. (1999)
- Herpes simplex virus type I disrupts the ATR-dependent DNA-damage response during lytic infection. Wilkinson, D.E., Weller, S.K. J. Cell. Sci. (2006)
- Linking transcriptional elongation and messenger RNA export to metastatic breast cancers. Guo, S., Hakimi, M.A., Baillat, D., Chen, X., Farber, M.J., Klein-Szanto, A.J., Cooch, N.S., Godwin, A.K., Shiekhattar, R. Cancer Res. (2005)
- Clinical application of therapeutic erythrocytapheresis (TEA). Valbonesi, M., Bruni, R. Transfusion science. (2000)
- Heterozygous mutations in TREX1 cause familial chilblain lupus and dominant Aicardi-Goutieres syndrome. Rice, G., Newman, W.G., Dean, J., Patrick, T., Parmar, R., Flintoff, K., Robins, P., Harvey, S., Hollis, T., O'Hara, A., Herrick, A.L., Bowden, A.P., Perrino, F.W., Lindahl, T., Barnes, D.E., Crow, Y.J. Am. J. Hum. Genet. (2007)
- The TREX1 double-stranded DNA degradation activity is defective in dominant mutations associated with autoimmune disease. Lehtinen, D.A., Harvey, S., Mulcahy, M.J., Hollis, T., Perrino, F.W. J. Biol. Chem. (2008)
- ATR and ATRIP: partners in checkpoint signaling. Cortez, D., Guntuku, S., Qin, J., Elledge, S.J. Science (2001)
- The exonuclease TREX1 is in the SET complex and acts in concert with NM23-H1 to degrade DNA during granzyme A-mediated cell death. Chowdhury, D., Beresford, P.J., Zhu, P., Zhang, D., Sung, J.S., Demple, B., Perrino, F.W., Lieberman, J. Mol. Cell (2006)
- ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts. Yoshioka, K., Yoshioka, Y., Hsieh, P. Mol. Cell (2006)
- Structure and expression of the TREX1 and TREX2 3' --> 5' exonuclease genes. Mazur, D.J., Perrino, F.W. J. Biol. Chem. (2001)
- ATRIP oligomerization is required for ATR-dependent checkpoint signaling. Ball, H.L., Cortez, D. J. Biol. Chem. (2005)
- The solution structure of REF2-I reveals interdomain interactions and regions involved in binding mRNA export factors and RNA. Golovanov, A.P., Hautbergue, G.M., Tintaru, A.M., Lian, L.Y., Wilson, S.A. RNA (2006)
- Amino-terminal domain of ATRIP contributes to intranuclear relocation of the ATR-ATRIP complex following DNA damage. Itakura, E., Takai, K.K., Umeda, K., Kimura, M., Ohsumi, M., Tamai, K., Matsuura, A. FEBS Lett. (2004)
- Resistance of 3'-phosphoglycolate DNA ends to digestion by mammalian DNase III. Inamdar, K.V., Yu, Y., Povirk, L.F. Radiat. Res. (2002)
- Structure of the dimeric exonuclease TREX1 in complex with DNA displays a proline-rich binding site for WW Domains. Brucet, M., Querol-Audí, J., Serra, M., Ramirez-Espain, X., Bertlik, K., Ruiz, L., Lloberas, J., Macias, M.J., Fita, I., Celada, A. J. Biol. Chem. (2007)
- The crystal structure of TREX1 explains the 3' nucleotide specificity and reveals a polyproline II helix for protein partnering. de Silva, U., Choudhury, S., Bailey, S.L., Harvey, S., Perrino, F.W., Hollis, T. J. Biol. Chem. (2007)
- Minichromosome maintenance proteins are direct targets of the ATM and ATR checkpoint kinases. Cortez, D., Glick, G., Elledge, S.J. Proc. Natl. Acad. Sci. U.S.A. (2004)
- A novel protein activity mediates DNA binding of an ATR-ATRIP complex. Bomgarden, R.D., Yean, D., Yee, M.C., Cimprich, K.A. J. Biol. Chem. (2004)
- Quaternary structure of ATR and effects of ATRIP and replication protein A on its DNA binding and kinase activities. Unsal-Kaçmaz, K., Sancar, A. Mol. Cell. Biol. (2004)
- Recruitment of ATR-ATRIP, Rad17, and 9-1-1 complexes to DNA damage. Yang, X.H., Zou, L. Meth. Enzymol. (2006)
- The effects of gray scale image processing on digital mammography interpretation performance. Cole, E.B., Pisano, E.D., Zeng, D., Muller, K., Aylward, S.R., Park, S., Kuzmiak, C., Koomen, M., Pavic, D., Walsh, R., Baker, J., Gimenez, E.I., Freimanis, R. Academic radiology. (2005)